Early Feeding Practices and Celiac Disease Prevention: Protocol for an Updated and Revised Systematic Review and Meta-Analysis
Uncertainty remains in regard to when, how, and in what form gluten should be introduced into the diet, particularly of infants genetically predisposed to developing celiac disease (CD). MEDLINE (PubMed), EMBASE, and Cochrane Central Register of Controlled Trials databases will be searched from ince...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/5/1040 |
| _version_ | 1797474155835162624 |
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| author | Hania Szajewska Raanan Shamir Anna Chmielewska Agata Stróżyk Bartłomiej M. Zalewski Renata Auricchio Sibylle Koletzko Ilma R. Korponay-Szabo Luisa Mearin Caroline Meijer Carmen Ribes-Koninckx Riccardo Troncone on behalf of the PREVENTCD Study Group |
| author_facet | Hania Szajewska Raanan Shamir Anna Chmielewska Agata Stróżyk Bartłomiej M. Zalewski Renata Auricchio Sibylle Koletzko Ilma R. Korponay-Szabo Luisa Mearin Caroline Meijer Carmen Ribes-Koninckx Riccardo Troncone on behalf of the PREVENTCD Study Group |
| author_sort | Hania Szajewska |
| collection | DOAJ |
| description | Uncertainty remains in regard to when, how, and in what form gluten should be introduced into the diet, particularly of infants genetically predisposed to developing celiac disease (CD). MEDLINE (PubMed), EMBASE, and Cochrane Central Register of Controlled Trials databases will be searched from inception. Randomized controlled trials (RCTs) and observational studies (cohort, case-control, or cross-sectional studies) investigating the association between early feeding practices and the risk of CD and/or CD autoimmunity will be included. In prospective studies, participants will be infants regardless of the risk of developing CD. For retrospective studies, participants will be children or adults with CD or presenting with positive serology indicative of CD. Interventions will be gluten-containing products of any type. Exposures will be breastfeeding and/or the introduction of gluten-containing products of any type. In control groups, there will be no exposure, different degrees of exposure (partial vs. exclusive breastfeeding, different amounts of gluten, etc.), or a placebo. The primary outcome measure will be CD or CD autoimmunity (i.e., anti-transglutaminase or anti-endomysial antibodies). At least two reviewers will independently assess the risk of bias using a validated risk assessment tool depending on study design. Disagreements will be resolved by discussion to achieve a consensus with the involvement of one or more additional reviewers if required. If appropriate, data will be pooled. If not, a narrative synthesis will be performed. The findings will be submitted to a peer-reviewed journal. |
| first_indexed | 2024-03-09T20:27:08Z |
| format | Article |
| id | doaj.art-523e2c05562c49799f811e006b8249c2 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:27:08Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-523e2c05562c49799f811e006b8249c22023-11-23T23:33:36ZengMDPI AGNutrients2072-66432022-02-01145104010.3390/nu14051040Early Feeding Practices and Celiac Disease Prevention: Protocol for an Updated and Revised Systematic Review and Meta-AnalysisHania Szajewska0Raanan Shamir1Anna Chmielewska2Agata Stróżyk3Bartłomiej M. Zalewski4Renata Auricchio5Sibylle Koletzko6Ilma R. Korponay-Szabo7Luisa Mearin8Caroline Meijer9Carmen Ribes-Koninckx10Riccardo Troncone11on behalf of the PREVENTCD Study GroupDepartment of Paediatrics, The Medical University of Warsaw, 02-091 Warsaw, PolandSchneider Children’s Medical Center of Israel, Institute of Gastroenterology, Nutrition and Liver Diseases, Petach Tikva 4920235, IsraelDepartment of Clinical Sciences, Pediatrics, Umeå University, 901 85 Umeå, SwedenDepartment of Paediatrics, The Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Paediatrics, The Medical University of Warsaw, 02-091 Warsaw, PolandPediatric Section European Laboratory for the Investigation of Food Induced Disease (ELFID), Department of Translation Medical Science, University Federico II, 80331 Naples, ItalyDepartment of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, 80337 Munich, GermanyDepartment of Pediatrics, Faculty of Medicine and Clinical Center, University of Debrecen, 4032 Debrecen, HungaryDepartment of Pediatrics, Leiden University Medical Center, Willem Alexander Children’s Hospital, 2300 RC Leiden, The NetherlandsDepartment of Pediatrics, Leiden University Medical Center, Willem Alexander Children’s Hospital, 2300 RC Leiden, The NetherlandsPediatric Gastroenterology and Hepatology, La Fe University Hospital, 46026 Valencia, SpainPediatric Section European Laboratory for the Investigation of Food Induced Disease (ELFID), Department of Translation Medical Science, University Federico II, 80331 Naples, ItalyUncertainty remains in regard to when, how, and in what form gluten should be introduced into the diet, particularly of infants genetically predisposed to developing celiac disease (CD). MEDLINE (PubMed), EMBASE, and Cochrane Central Register of Controlled Trials databases will be searched from inception. Randomized controlled trials (RCTs) and observational studies (cohort, case-control, or cross-sectional studies) investigating the association between early feeding practices and the risk of CD and/or CD autoimmunity will be included. In prospective studies, participants will be infants regardless of the risk of developing CD. For retrospective studies, participants will be children or adults with CD or presenting with positive serology indicative of CD. Interventions will be gluten-containing products of any type. Exposures will be breastfeeding and/or the introduction of gluten-containing products of any type. In control groups, there will be no exposure, different degrees of exposure (partial vs. exclusive breastfeeding, different amounts of gluten, etc.), or a placebo. The primary outcome measure will be CD or CD autoimmunity (i.e., anti-transglutaminase or anti-endomysial antibodies). At least two reviewers will independently assess the risk of bias using a validated risk assessment tool depending on study design. Disagreements will be resolved by discussion to achieve a consensus with the involvement of one or more additional reviewers if required. If appropriate, data will be pooled. If not, a narrative synthesis will be performed. The findings will be submitted to a peer-reviewed journal.https://www.mdpi.com/2072-6643/14/5/1040nutritionfeedinginfantschildrenceliac spruebreastfeeding |
| spellingShingle | Hania Szajewska Raanan Shamir Anna Chmielewska Agata Stróżyk Bartłomiej M. Zalewski Renata Auricchio Sibylle Koletzko Ilma R. Korponay-Szabo Luisa Mearin Caroline Meijer Carmen Ribes-Koninckx Riccardo Troncone on behalf of the PREVENTCD Study Group Early Feeding Practices and Celiac Disease Prevention: Protocol for an Updated and Revised Systematic Review and Meta-Analysis Nutrients nutrition feeding infants children celiac sprue breastfeeding |
| title | Early Feeding Practices and Celiac Disease Prevention: Protocol for an Updated and Revised Systematic Review and Meta-Analysis |
| title_full | Early Feeding Practices and Celiac Disease Prevention: Protocol for an Updated and Revised Systematic Review and Meta-Analysis |
| title_fullStr | Early Feeding Practices and Celiac Disease Prevention: Protocol for an Updated and Revised Systematic Review and Meta-Analysis |
| title_full_unstemmed | Early Feeding Practices and Celiac Disease Prevention: Protocol for an Updated and Revised Systematic Review and Meta-Analysis |
| title_short | Early Feeding Practices and Celiac Disease Prevention: Protocol for an Updated and Revised Systematic Review and Meta-Analysis |
| title_sort | early feeding practices and celiac disease prevention protocol for an updated and revised systematic review and meta analysis |
| topic | nutrition feeding infants children celiac sprue breastfeeding |
| url | https://www.mdpi.com/2072-6643/14/5/1040 |
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