Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer
Background: Over the last decade, studies have shown an increased incidence of colorectal cancer (CRC), particularly early onset colorectal cancer (EOCRC). Researchers have demonstrated that dietary behavior, especially among young adults, influences alterations in the gut microbial community, leadi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123222002958 |
| _version_ | 1797670294540779520 |
|---|---|
| author | Mutebi John Kenneth Hsin-Chi Tsai Chuan-Yin Fang Bashir Hussain Yi-Chou Chiu Bing-Mu Hsu |
| author_facet | Mutebi John Kenneth Hsin-Chi Tsai Chuan-Yin Fang Bashir Hussain Yi-Chou Chiu Bing-Mu Hsu |
| author_sort | Mutebi John Kenneth |
| collection | DOAJ |
| description | Background: Over the last decade, studies have shown an increased incidence of colorectal cancer (CRC), particularly early onset colorectal cancer (EOCRC). Researchers have demonstrated that dietary behavior, especially among young adults, influences alterations in the gut microbial community, leading to an increased accumulation of pathogenic gut microbiota and a decrease in beneficial ones. Unfortunately, CRC is likely to be diagnosed at a late stage, increasing CRC-related mortality. However, this alteration in the gut microbiota (gut dysbiosis) can be harnessed as a biomarker for non-invasive diagnosis, prognosis, prevention, and treatment of CRC in an effort to prevent late diagnosis and poor prognosis associated with CRC. Aim of review: This review discusses identification of potential biomarkers by targeting diet-mediated gut dysbiosis for the stage-specific diagnosis, prognosis, treatment, and prevention of CRC. Our findings provide a comprehensive insight into the potential of protumorigenic bacteria (e.g. pathogenic Escherichia coli, enterotoxigenic Bacteroides fragilis and Fusobacterium nucleatum) and their metabolites (e.g., colibactin and B. fragilis toxin) from gut dysbiosis as biomarkers for the diagnosis of CRC. Key scientific concepts of review: Collectively, a detailed understanding of the available data from current studies suggests that, further research on quantification of metabolites and stage-specific pathogenic microbial abundance is required for the diagnosis and treatment of CRC based on microbial dysbiosis. Specifically, future studies on faecal samples, from patient with CRC, should be conducted for F. nucleatum among different opportunistic bacteria, given its repeated occurrence in faecal samples and CRC biopsies in numerous studies. Finally, we discuss the potential of faecal microbial transplantation (FMT) as an intervention to restore damaged gut microbiota during CRC treatment and management. |
| first_indexed | 2024-03-11T20:57:36Z |
| format | Article |
| id | doaj.art-523ec6f1032546b0aa4aca3ce86a058e |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-03-11T20:57:36Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-523ec6f1032546b0aa4aca3ce86a058e2023-09-30T04:54:23ZengElsevierJournal of Advanced Research2090-12322023-10-01524557Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancerMutebi John Kenneth0Hsin-Chi Tsai1Chuan-Yin Fang2Bashir Hussain3Yi-Chou Chiu4Bing-Mu Hsu5Department of Earth and Environmental Sciences, National Chung Cheng University, Chiayi, Taiwan; Doctoral Program in Science, Technology, Environment and Mathematics, National Chung Cheng University, Chiayi County, TaiwanDepartment of Psychiatry, School of Medicine, Tzu Chi University, Hualien, Taiwan; Department of Psychiatry, Tzu-Chi General Hospital, Hualien, TaiwanDivision of Colon and Rectal Surgery, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, TaiwanDepartment of Earth and Environmental Sciences, National Chung Cheng University, Chiayi, Taiwan; Department of Biomedical Sciences, National Chung Cheng University, Chiayi, TaiwanGeneral Surgery, Surgical Department, Cheng Hsin General Hospital, Taipei 112, TaiwanDepartment of Earth and Environmental Sciences, National Chung Cheng University, Chiayi, Taiwan; Corresponding author.Background: Over the last decade, studies have shown an increased incidence of colorectal cancer (CRC), particularly early onset colorectal cancer (EOCRC). Researchers have demonstrated that dietary behavior, especially among young adults, influences alterations in the gut microbial community, leading to an increased accumulation of pathogenic gut microbiota and a decrease in beneficial ones. Unfortunately, CRC is likely to be diagnosed at a late stage, increasing CRC-related mortality. However, this alteration in the gut microbiota (gut dysbiosis) can be harnessed as a biomarker for non-invasive diagnosis, prognosis, prevention, and treatment of CRC in an effort to prevent late diagnosis and poor prognosis associated with CRC. Aim of review: This review discusses identification of potential biomarkers by targeting diet-mediated gut dysbiosis for the stage-specific diagnosis, prognosis, treatment, and prevention of CRC. Our findings provide a comprehensive insight into the potential of protumorigenic bacteria (e.g. pathogenic Escherichia coli, enterotoxigenic Bacteroides fragilis and Fusobacterium nucleatum) and their metabolites (e.g., colibactin and B. fragilis toxin) from gut dysbiosis as biomarkers for the diagnosis of CRC. Key scientific concepts of review: Collectively, a detailed understanding of the available data from current studies suggests that, further research on quantification of metabolites and stage-specific pathogenic microbial abundance is required for the diagnosis and treatment of CRC based on microbial dysbiosis. Specifically, future studies on faecal samples, from patient with CRC, should be conducted for F. nucleatum among different opportunistic bacteria, given its repeated occurrence in faecal samples and CRC biopsies in numerous studies. Finally, we discuss the potential of faecal microbial transplantation (FMT) as an intervention to restore damaged gut microbiota during CRC treatment and management.http://www.sciencedirect.com/science/article/pii/S2090123222002958Microbial dysbiosisColorectal cancerShort-chain fatty acidsHigh-fat diet (HFD)Non-invasive diagnosisFaecal microbial transplant (FMT) |
| spellingShingle | Mutebi John Kenneth Hsin-Chi Tsai Chuan-Yin Fang Bashir Hussain Yi-Chou Chiu Bing-Mu Hsu Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer Journal of Advanced Research Microbial dysbiosis Colorectal cancer Short-chain fatty acids High-fat diet (HFD) Non-invasive diagnosis Faecal microbial transplant (FMT) |
| title | Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer |
| title_full | Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer |
| title_fullStr | Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer |
| title_full_unstemmed | Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer |
| title_short | Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer |
| title_sort | diet mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis prognosis prevention and stage specific treatment of colorectal cancer |
| topic | Microbial dysbiosis Colorectal cancer Short-chain fatty acids High-fat diet (HFD) Non-invasive diagnosis Faecal microbial transplant (FMT) |
| url | http://www.sciencedirect.com/science/article/pii/S2090123222002958 |
| work_keys_str_mv | AT mutebijohnkenneth dietmediatedgutmicrobialcommunitymodulationandsignaturemetabolitesaspotentialbiomarkersforearlydiagnosisprognosispreventionandstagespecifictreatmentofcolorectalcancer AT hsinchitsai dietmediatedgutmicrobialcommunitymodulationandsignaturemetabolitesaspotentialbiomarkersforearlydiagnosisprognosispreventionandstagespecifictreatmentofcolorectalcancer AT chuanyinfang dietmediatedgutmicrobialcommunitymodulationandsignaturemetabolitesaspotentialbiomarkersforearlydiagnosisprognosispreventionandstagespecifictreatmentofcolorectalcancer AT bashirhussain dietmediatedgutmicrobialcommunitymodulationandsignaturemetabolitesaspotentialbiomarkersforearlydiagnosisprognosispreventionandstagespecifictreatmentofcolorectalcancer AT yichouchiu dietmediatedgutmicrobialcommunitymodulationandsignaturemetabolitesaspotentialbiomarkersforearlydiagnosisprognosispreventionandstagespecifictreatmentofcolorectalcancer AT bingmuhsu dietmediatedgutmicrobialcommunitymodulationandsignaturemetabolitesaspotentialbiomarkersforearlydiagnosisprognosispreventionandstagespecifictreatmentofcolorectalcancer |