Genetic architecture of common non-Alzheimer’s disease dementias
Frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and vascular dementia (VaD) are the most common forms of dementia after Alzheimer's disease (AD). The heterogeneity of these disorders and/or the clinical overlap with other diseases hinder the study of their genetic components. Eve...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Neurobiology of Disease |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996120302217 |
| _version_ | 1818353314481307648 |
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| author | Rita Guerreiro Elizabeth Gibbons Miguel Tábuas-Pereira Celia Kun-Rodrigues Gustavo C. Santo Jose Bras |
| author_facet | Rita Guerreiro Elizabeth Gibbons Miguel Tábuas-Pereira Celia Kun-Rodrigues Gustavo C. Santo Jose Bras |
| author_sort | Rita Guerreiro |
| collection | DOAJ |
| description | Frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and vascular dementia (VaD) are the most common forms of dementia after Alzheimer's disease (AD). The heterogeneity of these disorders and/or the clinical overlap with other diseases hinder the study of their genetic components. Even though Mendelian dementias are rare, the study of these forms of disease can have a significant impact in the lives of patients and families and have successfully brought to the fore many of the genes currently known to be involved in FTD and VaD, starting to give us a glimpse of the molecular mechanisms underlying these phenotypes. More recently, genome-wide association studies have also pointed to disease risk-associated loci. This has been particularly important for DLB where familial forms of disease are very rarely described. In this review we systematically describe the Mendelian and risk genes involved in these non-AD dementias in an effort to contribute to a better understanding of their genetic architecture, find differences and commonalities between different dementia phenotypes, and uncover areas that would benefit from more intense research endeavors. |
| first_indexed | 2024-12-13T19:07:34Z |
| format | Article |
| id | doaj.art-523ee7231c9146e78314c7531b51fc99 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-13T19:07:34Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-523ee7231c9146e78314c7531b51fc992022-12-21T23:34:29ZengElsevierNeurobiology of Disease1095-953X2020-08-01142104946Genetic architecture of common non-Alzheimer’s disease dementiasRita Guerreiro0Elizabeth Gibbons1Miguel Tábuas-Pereira2Celia Kun-Rodrigues3Gustavo C. Santo4Jose Bras5Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA; Division of Psychiatry and Behavioral Medicine, Michigan State University College of Human Medicine, Grand Rapids, MI, USA; Corresponding author at: Center for Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave. N.E., Grand Rapids, MI 49503-2518, USA.Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USADepartment of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, PortugalCenter for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USADepartment of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, PortugalCenter for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA; Division of Psychiatry and Behavioral Medicine, Michigan State University College of Human Medicine, Grand Rapids, MI, USAFrontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and vascular dementia (VaD) are the most common forms of dementia after Alzheimer's disease (AD). The heterogeneity of these disorders and/or the clinical overlap with other diseases hinder the study of their genetic components. Even though Mendelian dementias are rare, the study of these forms of disease can have a significant impact in the lives of patients and families and have successfully brought to the fore many of the genes currently known to be involved in FTD and VaD, starting to give us a glimpse of the molecular mechanisms underlying these phenotypes. More recently, genome-wide association studies have also pointed to disease risk-associated loci. This has been particularly important for DLB where familial forms of disease are very rarely described. In this review we systematically describe the Mendelian and risk genes involved in these non-AD dementias in an effort to contribute to a better understanding of their genetic architecture, find differences and commonalities between different dementia phenotypes, and uncover areas that would benefit from more intense research endeavors.http://www.sciencedirect.com/science/article/pii/S0969996120302217 |
| spellingShingle | Rita Guerreiro Elizabeth Gibbons Miguel Tábuas-Pereira Celia Kun-Rodrigues Gustavo C. Santo Jose Bras Genetic architecture of common non-Alzheimer’s disease dementias Neurobiology of Disease |
| title | Genetic architecture of common non-Alzheimer’s disease dementias |
| title_full | Genetic architecture of common non-Alzheimer’s disease dementias |
| title_fullStr | Genetic architecture of common non-Alzheimer’s disease dementias |
| title_full_unstemmed | Genetic architecture of common non-Alzheimer’s disease dementias |
| title_short | Genetic architecture of common non-Alzheimer’s disease dementias |
| title_sort | genetic architecture of common non alzheimer s disease dementias |
| url | http://www.sciencedirect.com/science/article/pii/S0969996120302217 |
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