Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
23-Hydroxybetulinic acid (<strong>1</strong>) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated <em>in vitro</em> for their antitumor activities against five cell lines (A549, BEL-7402, SF-...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-07-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/17/8/8832 |
| _version_ | 1811322220577816576 |
|---|---|
| author | Yijun Sun Wencai Ye Xiaoming Wu Fei Sun Jinyi Xu Yi Bi Wenwen Huang |
| author_facet | Yijun Sun Wencai Ye Xiaoming Wu Fei Sun Jinyi Xu Yi Bi Wenwen Huang |
| author_sort | Yijun Sun |
| collection | DOAJ |
| description | 23-Hydroxybetulinic acid (<strong>1</strong>) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated <em>in vitro</em> for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60)<em>.</em> Among the obtained compounds, <strong>6i</strong> had the most potent antitumor activity, with the IC<sub>50</sub> values of 8.35 µM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma<em> in vivo</em>. |
| first_indexed | 2024-04-13T13:31:22Z |
| format | Article |
| id | doaj.art-52407bc43e3d4d548fa5a8e55ff98aac |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T13:31:22Z |
| publishDate | 2012-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-52407bc43e3d4d548fa5a8e55ff98aac2022-12-22T02:44:58ZengMDPI AGMolecules1420-30492012-07-011788832884110.3390/molecules17088832Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent CandidatesYijun SunWencai YeXiaoming WuFei SunJinyi XuYi BiWenwen Huang23-Hydroxybetulinic acid (<strong>1</strong>) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated <em>in vitro</em> for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60)<em>.</em> Among the obtained compounds, <strong>6i</strong> had the most potent antitumor activity, with the IC<sub>50</sub> values of 8.35 µM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma<em> in vivo</em>.http://www.mdpi.com/1420-3049/17/8/883223-hydroxybetulinic acidC-28 ester derivativesantitumor activitystructure-activity relationships |
| spellingShingle | Yijun Sun Wencai Ye Xiaoming Wu Fei Sun Jinyi Xu Yi Bi Wenwen Huang Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates Molecules 23-hydroxybetulinic acid C-28 ester derivatives antitumor activity structure-activity relationships |
| title | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
| title_full | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
| title_fullStr | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
| title_full_unstemmed | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
| title_short | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
| title_sort | synthesis and biological activity of 23 hydroxybetulinic acid c 28 ester derivatives as antitumor agent candidates |
| topic | 23-hydroxybetulinic acid C-28 ester derivatives antitumor activity structure-activity relationships |
| url | http://www.mdpi.com/1420-3049/17/8/8832 |
| work_keys_str_mv | AT yijunsun synthesisandbiologicalactivityof23hydroxybetulinicacidc28esterderivativesasantitumoragentcandidates AT wencaiye synthesisandbiologicalactivityof23hydroxybetulinicacidc28esterderivativesasantitumoragentcandidates AT xiaomingwu synthesisandbiologicalactivityof23hydroxybetulinicacidc28esterderivativesasantitumoragentcandidates AT feisun synthesisandbiologicalactivityof23hydroxybetulinicacidc28esterderivativesasantitumoragentcandidates AT jinyixu synthesisandbiologicalactivityof23hydroxybetulinicacidc28esterderivativesasantitumoragentcandidates AT yibi synthesisandbiologicalactivityof23hydroxybetulinicacidc28esterderivativesasantitumoragentcandidates AT wenwenhuang synthesisandbiologicalactivityof23hydroxybetulinicacidc28esterderivativesasantitumoragentcandidates |