Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
23-Hydroxybetulinic acid (<strong>1</strong>) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated <em>in vitro</em> for their antitumor activities against five cell lines (A549, BEL-7402, SF-...
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MDPI AG
2012-07-01
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Series: | Molecules |
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Online Access: | http://www.mdpi.com/1420-3049/17/8/8832 |
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author | Yijun Sun Wencai Ye Xiaoming Wu Fei Sun Jinyi Xu Yi Bi Wenwen Huang |
author_facet | Yijun Sun Wencai Ye Xiaoming Wu Fei Sun Jinyi Xu Yi Bi Wenwen Huang |
author_sort | Yijun Sun |
collection | DOAJ |
description | 23-Hydroxybetulinic acid (<strong>1</strong>) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated <em>in vitro</em> for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60)<em>.</em> Among the obtained compounds, <strong>6i</strong> had the most potent antitumor activity, with the IC<sub>50</sub> values of 8.35 µM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma<em> in vivo</em>. |
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institution | Directory Open Access Journal |
issn | 1420-3049 |
language | English |
last_indexed | 2024-04-13T13:31:22Z |
publishDate | 2012-07-01 |
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series | Molecules |
spelling | doaj.art-52407bc43e3d4d548fa5a8e55ff98aac2022-12-22T02:44:58ZengMDPI AGMolecules1420-30492012-07-011788832884110.3390/molecules17088832Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent CandidatesYijun SunWencai YeXiaoming WuFei SunJinyi XuYi BiWenwen Huang23-Hydroxybetulinic acid (<strong>1</strong>) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated <em>in vitro</em> for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60)<em>.</em> Among the obtained compounds, <strong>6i</strong> had the most potent antitumor activity, with the IC<sub>50</sub> values of 8.35 µM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma<em> in vivo</em>.http://www.mdpi.com/1420-3049/17/8/883223-hydroxybetulinic acidC-28 ester derivativesantitumor activitystructure-activity relationships |
spellingShingle | Yijun Sun Wencai Ye Xiaoming Wu Fei Sun Jinyi Xu Yi Bi Wenwen Huang Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates Molecules 23-hydroxybetulinic acid C-28 ester derivatives antitumor activity structure-activity relationships |
title | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
title_full | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
title_fullStr | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
title_full_unstemmed | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
title_short | Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates |
title_sort | synthesis and biological activity of 23 hydroxybetulinic acid c 28 ester derivatives as antitumor agent candidates |
topic | 23-hydroxybetulinic acid C-28 ester derivatives antitumor activity structure-activity relationships |
url | http://www.mdpi.com/1420-3049/17/8/8832 |
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