Contrast-Enhanced Spectral Mammography Assessment of Patients Treated with Neoadjuvant Chemotherapy for Breast Cancer
Background: Evaluating the tumor response to neoadjuvant chemotherapy is key to planning further therapy of breast cancer. Our study aimed to evaluate the effectiveness of low-energy and subtraction contrast-enhanced spectral mammography (CESM) images in the detection of complete response (CR) for n...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/28/5/298 |
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| author | Katarzyna Steinhof-Radwańska Anna Grażyńska Andrzej Lorek Iwona Gisterek Anna Barczyk-Gutowska Agnieszka Bobola Karolina Okas Zuzanna Lelek Irmina Morawska Jakub Potoczny Paweł Niemiec Karol Szyluk |
| author_facet | Katarzyna Steinhof-Radwańska Anna Grażyńska Andrzej Lorek Iwona Gisterek Anna Barczyk-Gutowska Agnieszka Bobola Karolina Okas Zuzanna Lelek Irmina Morawska Jakub Potoczny Paweł Niemiec Karol Szyluk |
| author_sort | Katarzyna Steinhof-Radwańska |
| collection | DOAJ |
| description | Background: Evaluating the tumor response to neoadjuvant chemotherapy is key to planning further therapy of breast cancer. Our study aimed to evaluate the effectiveness of low-energy and subtraction contrast-enhanced spectral mammography (CESM) images in the detection of complete response (CR) for neoadjuvant chemotherapy (NAC) in breast cancer. Methods: A total of 63 female patients were qualified for our retrospective analysis. Low-energy and subtraction CESM images just before the beginning of NAC and as a follow-up examination 2 weeks before the end of chemotherapy were compared with one another and assessed for compliance with the postoperative histopathological examination (HP). The response to preoperative chemotherapy was evaluated based on the RECIST 1.1 criteria (Response Evaluation Criteria in Solid Tumors). Results: Low-energy images tend to overestimate residual lesions (6.28 mm) and subtraction images tend to underestimate them (2.75 mm). The sensitivity of low-energy images in forecasting CR amounted to 33.33%, while the specificity was 92.86%. In the case of subtraction CESM, the sensitivity amounted to 85.71% and the specificity to 71.42%. Conclusions: CESM is characterized by high sensitivity in the assessment of CR after NAC. The use of only morphological assessment is insufficient. CESM correlates well with the size of residual lesions on histopathological examination but tends to underestimate the dimensions. |
| first_indexed | 2024-03-10T06:37:26Z |
| format | Article |
| id | doaj.art-52418a5f97484ded89c63b2b46cbe4b1 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T06:37:26Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-52418a5f97484ded89c63b2b46cbe4b12023-11-22T17:54:34ZengMDPI AGCurrent Oncology1198-00521718-77292021-09-012853448346210.3390/curroncol28050298Contrast-Enhanced Spectral Mammography Assessment of Patients Treated with Neoadjuvant Chemotherapy for Breast CancerKatarzyna Steinhof-Radwańska0Anna Grażyńska1Andrzej Lorek2Iwona Gisterek3Anna Barczyk-Gutowska4Agnieszka Bobola5Karolina Okas6Zuzanna Lelek7Irmina Morawska8Jakub Potoczny9Paweł Niemiec10Karol Szyluk11Department of Radiology and Nuclear Medicine, Prof. Kornel Gibiński Independent Public Central Clinical Hospital, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandStudents’ Scientific Society, Department of Radiology and Nuclear Medicine, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandDepartment of Oncological Surgery, Prof. Kornel Gibiński Independent Public Central Clinical Hospital, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandDepartment of Oncology and Radiotherapy, Prof. Kornel Gibiński Independent Public Central Clinical Hospital, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandDepartment of Radiology and Nuclear Medicine, Prof. Kornel Gibiński Independent Public Central Clinical Hospital, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandDepartment of Oncology and Radiotherapy, Prof. Kornel Gibiński Independent Public Central Clinical Hospital, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandStudents’ Scientific Society, Department of Radiology and Nuclear Medicine, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandStudents’ Scientific Society, Department of Radiology and Nuclear Medicine, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandStudents’ Scientific Society, Department of Radiology and Nuclear Medicine, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandStudents’ Scientific Society, Department of Radiology and Nuclear Medicine, Medical University of Silesia, Medyków 18, 40-514 Katowice, PolandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland1st Department of Orthopaedic and Trauma Surgery, District Hospital of Orthopaedics and Trauma Surgery, Bytomska 62, 41-940 Piekary Śląskie, PolandBackground: Evaluating the tumor response to neoadjuvant chemotherapy is key to planning further therapy of breast cancer. Our study aimed to evaluate the effectiveness of low-energy and subtraction contrast-enhanced spectral mammography (CESM) images in the detection of complete response (CR) for neoadjuvant chemotherapy (NAC) in breast cancer. Methods: A total of 63 female patients were qualified for our retrospective analysis. Low-energy and subtraction CESM images just before the beginning of NAC and as a follow-up examination 2 weeks before the end of chemotherapy were compared with one another and assessed for compliance with the postoperative histopathological examination (HP). The response to preoperative chemotherapy was evaluated based on the RECIST 1.1 criteria (Response Evaluation Criteria in Solid Tumors). Results: Low-energy images tend to overestimate residual lesions (6.28 mm) and subtraction images tend to underestimate them (2.75 mm). The sensitivity of low-energy images in forecasting CR amounted to 33.33%, while the specificity was 92.86%. In the case of subtraction CESM, the sensitivity amounted to 85.71% and the specificity to 71.42%. Conclusions: CESM is characterized by high sensitivity in the assessment of CR after NAC. The use of only morphological assessment is insufficient. CESM correlates well with the size of residual lesions on histopathological examination but tends to underestimate the dimensions.https://www.mdpi.com/1718-7729/28/5/298contrast-enhanced spectral mammographybreast cancerneoadjuvant chemotherapycomplete responseresponse evaluation criteria in solid tumors |
| spellingShingle | Katarzyna Steinhof-Radwańska Anna Grażyńska Andrzej Lorek Iwona Gisterek Anna Barczyk-Gutowska Agnieszka Bobola Karolina Okas Zuzanna Lelek Irmina Morawska Jakub Potoczny Paweł Niemiec Karol Szyluk Contrast-Enhanced Spectral Mammography Assessment of Patients Treated with Neoadjuvant Chemotherapy for Breast Cancer Current Oncology contrast-enhanced spectral mammography breast cancer neoadjuvant chemotherapy complete response response evaluation criteria in solid tumors |
| title | Contrast-Enhanced Spectral Mammography Assessment of Patients Treated with Neoadjuvant Chemotherapy for Breast Cancer |
| title_full | Contrast-Enhanced Spectral Mammography Assessment of Patients Treated with Neoadjuvant Chemotherapy for Breast Cancer |
| title_fullStr | Contrast-Enhanced Spectral Mammography Assessment of Patients Treated with Neoadjuvant Chemotherapy for Breast Cancer |
| title_full_unstemmed | Contrast-Enhanced Spectral Mammography Assessment of Patients Treated with Neoadjuvant Chemotherapy for Breast Cancer |
| title_short | Contrast-Enhanced Spectral Mammography Assessment of Patients Treated with Neoadjuvant Chemotherapy for Breast Cancer |
| title_sort | contrast enhanced spectral mammography assessment of patients treated with neoadjuvant chemotherapy for breast cancer |
| topic | contrast-enhanced spectral mammography breast cancer neoadjuvant chemotherapy complete response response evaluation criteria in solid tumors |
| url | https://www.mdpi.com/1718-7729/28/5/298 |
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