Advances in Antioxidant Applications for Combating <sup>131</sup>I Side Effects in Thyroid Cancer Treatment
Thyroid cancer is the most common endocrine cancer, and its prevalence has been increasing for decades. Approx. 95% of differentiated thyroid carcinomas are treated using <sup>131</sup>iodine (<sup>131</sup>I), a radionuclide with a half-life of 8 days, to achieve optimal thy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/6/529 |
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| author | Li Yang Jiahui Ma Pengyu Lei Jia Yi Yilei Ma Zhongke Huang Tingjue Wang Haiyan Ping Danping Ruan Da Sun Hongying Pan |
| author_facet | Li Yang Jiahui Ma Pengyu Lei Jia Yi Yilei Ma Zhongke Huang Tingjue Wang Haiyan Ping Danping Ruan Da Sun Hongying Pan |
| author_sort | Li Yang |
| collection | DOAJ |
| description | Thyroid cancer is the most common endocrine cancer, and its prevalence has been increasing for decades. Approx. 95% of differentiated thyroid carcinomas are treated using <sup>131</sup>iodine (<sup>131</sup>I), a radionuclide with a half-life of 8 days, to achieve optimal thyroid residual ablation following thyroidectomy. However, while <sup>131</sup>I is highly enriched in eliminating thyroid tissue, it can also retain and damage other body parts (salivary glands, liver, etc.) without selectivity, and even trigger salivary gland dysfunction, secondary cancer, and other side effects. A significant amount of data suggests that the primary mechanism for these side effects is the excessive production of reactive oxygen species, causing a severe imbalance of oxidant/antioxidant in the cellular components, resulting in secondary DNA damage and abnormal vascular permeability. Antioxidants are substances that are capable of binding free radicals and reducing or preventing the oxidation of the substrate in a significant way. These compounds can help prevent damage caused by free radicals, which can attack lipids, protein amino acids, polyunsaturated fatty acids, and double bonds of DNA bases. Based on this, the rational utilization of the free radical scavenging function of antioxidants to maximize a reduction in <sup>131</sup>I side effects is a promising medical strategy. This review provides an overview of the side effects of <sup>131</sup>I, the mechanisms by which <sup>131</sup>I causes oxidative stress-mediated damage, and the potential of natural and synthetic antioxidants in ameliorating the side effects of <sup>131</sup>I. Finally, the disadvantages of the clinical application of antioxidants and their improving strategies are prospected. Clinicians and nursing staff can use this information to alleviate <sup>131</sup>I side effects in the future, both effectively and reasonably. |
| first_indexed | 2024-03-11T01:51:59Z |
| format | Article |
| id | doaj.art-52442eebfd164b0489a16b2628541b76 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-11T01:51:59Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-52442eebfd164b0489a16b2628541b762023-11-18T12:54:53ZengMDPI AGToxics2305-63042023-06-0111652910.3390/toxics11060529Advances in Antioxidant Applications for Combating <sup>131</sup>I Side Effects in Thyroid Cancer TreatmentLi Yang0Jiahui Ma1Pengyu Lei2Jia Yi3Yilei Ma4Zhongke Huang5Tingjue Wang6Haiyan Ping7Danping Ruan8Da Sun9Hongying Pan10Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou 325035, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou 325035, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou 325035, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou 325035, ChinaSir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, ChinaSir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, ChinaSir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, ChinaSir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, ChinaInstitute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou 325035, ChinaSir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, ChinaThyroid cancer is the most common endocrine cancer, and its prevalence has been increasing for decades. Approx. 95% of differentiated thyroid carcinomas are treated using <sup>131</sup>iodine (<sup>131</sup>I), a radionuclide with a half-life of 8 days, to achieve optimal thyroid residual ablation following thyroidectomy. However, while <sup>131</sup>I is highly enriched in eliminating thyroid tissue, it can also retain and damage other body parts (salivary glands, liver, etc.) without selectivity, and even trigger salivary gland dysfunction, secondary cancer, and other side effects. A significant amount of data suggests that the primary mechanism for these side effects is the excessive production of reactive oxygen species, causing a severe imbalance of oxidant/antioxidant in the cellular components, resulting in secondary DNA damage and abnormal vascular permeability. Antioxidants are substances that are capable of binding free radicals and reducing or preventing the oxidation of the substrate in a significant way. These compounds can help prevent damage caused by free radicals, which can attack lipids, protein amino acids, polyunsaturated fatty acids, and double bonds of DNA bases. Based on this, the rational utilization of the free radical scavenging function of antioxidants to maximize a reduction in <sup>131</sup>I side effects is a promising medical strategy. This review provides an overview of the side effects of <sup>131</sup>I, the mechanisms by which <sup>131</sup>I causes oxidative stress-mediated damage, and the potential of natural and synthetic antioxidants in ameliorating the side effects of <sup>131</sup>I. Finally, the disadvantages of the clinical application of antioxidants and their improving strategies are prospected. Clinicians and nursing staff can use this information to alleviate <sup>131</sup>I side effects in the future, both effectively and reasonably.https://www.mdpi.com/2305-6304/11/6/529thyroid cancer<sup>131</sup>Ioxidative stressantioxidantDNA damage |
| spellingShingle | Li Yang Jiahui Ma Pengyu Lei Jia Yi Yilei Ma Zhongke Huang Tingjue Wang Haiyan Ping Danping Ruan Da Sun Hongying Pan Advances in Antioxidant Applications for Combating <sup>131</sup>I Side Effects in Thyroid Cancer Treatment Toxics thyroid cancer <sup>131</sup>I oxidative stress antioxidant DNA damage |
| title | Advances in Antioxidant Applications for Combating <sup>131</sup>I Side Effects in Thyroid Cancer Treatment |
| title_full | Advances in Antioxidant Applications for Combating <sup>131</sup>I Side Effects in Thyroid Cancer Treatment |
| title_fullStr | Advances in Antioxidant Applications for Combating <sup>131</sup>I Side Effects in Thyroid Cancer Treatment |
| title_full_unstemmed | Advances in Antioxidant Applications for Combating <sup>131</sup>I Side Effects in Thyroid Cancer Treatment |
| title_short | Advances in Antioxidant Applications for Combating <sup>131</sup>I Side Effects in Thyroid Cancer Treatment |
| title_sort | advances in antioxidant applications for combating sup 131 sup i side effects in thyroid cancer treatment |
| topic | thyroid cancer <sup>131</sup>I oxidative stress antioxidant DNA damage |
| url | https://www.mdpi.com/2305-6304/11/6/529 |
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