Role of antimicrobial peptides in periodontal innate defense mechanism
The periodontal epithelium neighboring the tooth is precise to form a seal and attachment around the tooth. This exclusive function imparts unique challenges to the tissue and leads to certain vulnerabilities allied with periodontal disease, particularly in view of the continual exposure to the bact...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Oral Research and Review |
| Subjects: | |
| Online Access: | http://www.jorr.org/article.asp?issn=2249-4987;year=2015;volume=7;issue=2;spage=74;epage=76;aulast=Mishra |
| _version_ | 1811208677125783552 |
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| author | Ashank Mishra Bagalkotkr Apeksha Pradeep Koppolu Swapna Amara Lingam |
| author_facet | Ashank Mishra Bagalkotkr Apeksha Pradeep Koppolu Swapna Amara Lingam |
| author_sort | Ashank Mishra |
| collection | DOAJ |
| description | The periodontal epithelium neighboring the tooth is precise to form a seal and attachment around the tooth. This exclusive function imparts unique challenges to the tissue and leads to certain vulnerabilities allied with periodontal disease, particularly in view of the continual exposure to the bacterial biofilm (dental plaque) that form that is formed on the tooth surface at the junction of the soft tissue. It is obvious that oral epithelial cells can counter unbroken microbial challenges from dental plaque by the production of antimicrobial peptides (AMPs), chemokines and cytokines that boost inflammation and immune response in periodontal tissues. AMPs are early responders of the innate immune system that search and destroy invading pathogens. The large variety of AMPs presumably allows for an effective response to the large variety of microorganisms that invade the mouth and airways. The present paper portrays the association between altered expression of AMPs and some types of periodontitis along with AMPs and their clinical significance in other oral diseases. |
| first_indexed | 2024-04-12T04:25:36Z |
| format | Article |
| id | doaj.art-52443054a1324fd0978d9bcf5311bd8d |
| institution | Directory Open Access Journal |
| issn | 2249-4987 2394-2541 |
| language | English |
| last_indexed | 2024-04-12T04:25:36Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Oral Research and Review |
| spelling | doaj.art-52443054a1324fd0978d9bcf5311bd8d2022-12-22T03:48:05ZengWolters Kluwer Medknow PublicationsJournal of Oral Research and Review2249-49872394-25412015-01-0172747610.4103/2249-4987.172500Role of antimicrobial peptides in periodontal innate defense mechanismAshank MishraBagalkotkr ApekshaPradeep KoppoluSwapna Amara LingamThe periodontal epithelium neighboring the tooth is precise to form a seal and attachment around the tooth. This exclusive function imparts unique challenges to the tissue and leads to certain vulnerabilities allied with periodontal disease, particularly in view of the continual exposure to the bacterial biofilm (dental plaque) that form that is formed on the tooth surface at the junction of the soft tissue. It is obvious that oral epithelial cells can counter unbroken microbial challenges from dental plaque by the production of antimicrobial peptides (AMPs), chemokines and cytokines that boost inflammation and immune response in periodontal tissues. AMPs are early responders of the innate immune system that search and destroy invading pathogens. The large variety of AMPs presumably allows for an effective response to the large variety of microorganisms that invade the mouth and airways. The present paper portrays the association between altered expression of AMPs and some types of periodontitis along with AMPs and their clinical significance in other oral diseases.http://www.jorr.org/article.asp?issn=2249-4987;year=2015;volume=7;issue=2;spage=74;epage=76;aulast=MishraAntimicrobial peptidescathelicidinsdefensins |
| spellingShingle | Ashank Mishra Bagalkotkr Apeksha Pradeep Koppolu Swapna Amara Lingam Role of antimicrobial peptides in periodontal innate defense mechanism Journal of Oral Research and Review Antimicrobial peptides cathelicidins defensins |
| title | Role of antimicrobial peptides in periodontal innate defense mechanism |
| title_full | Role of antimicrobial peptides in periodontal innate defense mechanism |
| title_fullStr | Role of antimicrobial peptides in periodontal innate defense mechanism |
| title_full_unstemmed | Role of antimicrobial peptides in periodontal innate defense mechanism |
| title_short | Role of antimicrobial peptides in periodontal innate defense mechanism |
| title_sort | role of antimicrobial peptides in periodontal innate defense mechanism |
| topic | Antimicrobial peptides cathelicidins defensins |
| url | http://www.jorr.org/article.asp?issn=2249-4987;year=2015;volume=7;issue=2;spage=74;epage=76;aulast=Mishra |
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