Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis
The similarity between pustular psoriasis (PP) and acute generalized exanthematous pustulosis (AGEP) poses problems in the diagnosis and treatment of these two conditions. Significant clinical and histopathologic overlap exists between PP and AGEP. PP is an inflammatory disorder that has numerous cl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/10/1004 |
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| author | Morgan Sussman Anthony Napodano Simo Huang Abhirup Are Sylvia Hsu Kiran Motaparthi |
| author_facet | Morgan Sussman Anthony Napodano Simo Huang Abhirup Are Sylvia Hsu Kiran Motaparthi |
| author_sort | Morgan Sussman |
| collection | DOAJ |
| description | The similarity between pustular psoriasis (PP) and acute generalized exanthematous pustulosis (AGEP) poses problems in the diagnosis and treatment of these two conditions. Significant clinical and histopathologic overlap exists between PP and AGEP. PP is an inflammatory disorder that has numerous clinical subtypes, but all with sterile pustules composed of neutrophils. AGEP is a severe cutaneous adverse reaction that is also characterized by non-follicular sterile pustules. Clinical features that suggest a diagnosis of PP over AGEP include a history of psoriasis and the presence of scaling plaques. Histologically, eosinophilic spongiosis, vacuolar interface dermatitis, and dermal eosinophilia favor a diagnosis of AGEP over PP. Importantly, PP and AGEP vary in clinical course and treatment. PP treatment involves topical steroids, oral retinoids, and systemic immunosuppressants. Newer therapies targeting IL-36, IL-23, IL-1, and PDE-4 have been investigated. The removal of the offending agent is a crucial part of the treatment of AGEP. |
| first_indexed | 2024-03-10T06:24:53Z |
| format | Article |
| id | doaj.art-52457c46ee08450288bffb829f2d5525 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T06:24:53Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-52457c46ee08450288bffb829f2d55252023-11-22T19:03:15ZengMDPI AGMedicina1010-660X1648-91442021-09-015710100410.3390/medicina57101004Pustular Psoriasis and Acute Generalized Exanthematous PustulosisMorgan Sussman0Anthony Napodano1Simo Huang2Abhirup Are3Sylvia Hsu4Kiran Motaparthi5Department of Dermatology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USADepartment of Dermatology, University of Florida College of Medicine, Gainesville, FL 32610, USADepartment of Dermatology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USACollege of Medicine, University of Florida, Gainesville, FL 32606, USADepartment of Dermatology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USADepartment of Dermatology, University of Florida College of Medicine, Gainesville, FL 32610, USAThe similarity between pustular psoriasis (PP) and acute generalized exanthematous pustulosis (AGEP) poses problems in the diagnosis and treatment of these two conditions. Significant clinical and histopathologic overlap exists between PP and AGEP. PP is an inflammatory disorder that has numerous clinical subtypes, but all with sterile pustules composed of neutrophils. AGEP is a severe cutaneous adverse reaction that is also characterized by non-follicular sterile pustules. Clinical features that suggest a diagnosis of PP over AGEP include a history of psoriasis and the presence of scaling plaques. Histologically, eosinophilic spongiosis, vacuolar interface dermatitis, and dermal eosinophilia favor a diagnosis of AGEP over PP. Importantly, PP and AGEP vary in clinical course and treatment. PP treatment involves topical steroids, oral retinoids, and systemic immunosuppressants. Newer therapies targeting IL-36, IL-23, IL-1, and PDE-4 have been investigated. The removal of the offending agent is a crucial part of the treatment of AGEP.https://www.mdpi.com/1648-9144/57/10/1004pustular psoriasisacute generalized exanthematous pustulosissevere cutaneous adverse reactionchronic inflammatory disorder |
| spellingShingle | Morgan Sussman Anthony Napodano Simo Huang Abhirup Are Sylvia Hsu Kiran Motaparthi Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis Medicina pustular psoriasis acute generalized exanthematous pustulosis severe cutaneous adverse reaction chronic inflammatory disorder |
| title | Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis |
| title_full | Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis |
| title_fullStr | Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis |
| title_full_unstemmed | Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis |
| title_short | Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis |
| title_sort | pustular psoriasis and acute generalized exanthematous pustulosis |
| topic | pustular psoriasis acute generalized exanthematous pustulosis severe cutaneous adverse reaction chronic inflammatory disorder |
| url | https://www.mdpi.com/1648-9144/57/10/1004 |
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