Proton- and ammonium- sensing by histaminergic neurons controlling wakefulness.

Proton- and ammonium- sensing by histaminergic neurons controlling wakefulness.

Orexinergic and histaminergic neurons in the posterior hypothalamus are involved in the control of arousal. Extracellular levels of acid /CO2 are fundamental physicochemical signals controlling wakefulness and breathing. Acidification excites orexinergic neurons like the chemosensory neurons in the...

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Bibliographic Details
Main Authors: Yvgenij eYanovsky, Jeffrey M Zigman, Anna L. Kernder, Alisa eBein, Ichiro eSakata, Sherri eOsborne-lawrence, Helmut L. Haas, Olga A. eSergeeva
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-04-01
Series:Frontiers in Systems Neuroscience
Subjects:
Histamine
Hypothalamus
real-time RT-PCR
ASIC
proton
patch-clamp
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00023/full

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