Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease

Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease

Background: Individuals with specific <i>TREM2</i> gene variants that encode for a Triggering Receptor Expressed on Myeloid cells 2 have a higher prevalence of Alzheimer’s disease (AD). By interacting with amyloid and apolipoproteins, the TREM2 receptor regulates the number of myeloid ce...

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Bibliographic Details
Main Authors: Ena Španić Popovački, Mirjana Babić Leko, Lea Langer Horvat, Klara Brgić, Željka Vogrinc, Marina Boban, Nataša Klepac, Fran Borovečki, Goran Šimić
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Neurology International
Subjects:
inflammasome
microglia
mild cognitive impairment
plasma samples
tau protein
ELISA method
Online Access:https://www.mdpi.com/2035-8377/15/3/53

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