Langerhans cell histiocytosis of the cervical spine in a child: A case report and review of the literature
Langerhans cell histiocytosis (LCH) is a rare disorder of clonal proliferation of dendritic cell mostly seen in children. It consists in various clinical manifestations from a single lytic bone lesion to multisystemic lesions with organ dysfunction. Atlantoaxial involvement by LCH is very rare, espe...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Pediatric Hematology Oncology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468124522002492 |
| _version_ | 1797975169321402368 |
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| author | Ines Trabelsi Soumaya Kbaier Samia Rekaya Monia Ouederni Samia Hamouda Khedija Boussetta |
| author_facet | Ines Trabelsi Soumaya Kbaier Samia Rekaya Monia Ouederni Samia Hamouda Khedija Boussetta |
| author_sort | Ines Trabelsi |
| collection | DOAJ |
| description | Langerhans cell histiocytosis (LCH) is a rare disorder of clonal proliferation of dendritic cell mostly seen in children. It consists in various clinical manifestations from a single lytic bone lesion to multisystemic lesions with organ dysfunction. Atlantoaxial involvement by LCH is very rare, especially in a young child. We report a rare case of the cervical spine LCH resulting in dragging torticollis as the first symptom lasting for 4 weeks in a 6-year-old boy. Histological features were consistent with the diagnosis. The patient received chemotherapy with steroids and he underwent a laminectomy with arthrodesis. He remained well with no evidence of recurrence during the follow-up period. The rarity of this disease as well as the site of bone involvement draws attention for early diagnosis to prevent neurological lesions and other late complications. |
| first_indexed | 2024-04-11T04:31:21Z |
| format | Article |
| id | doaj.art-524ade219cd648da9612a454f79013cf |
| institution | Directory Open Access Journal |
| issn | 2468-1245 |
| language | English |
| last_indexed | 2024-04-11T04:31:21Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatric Hematology Oncology Journal |
| spelling | doaj.art-524ade219cd648da9612a454f79013cf2022-12-29T04:13:44ZengElsevierPediatric Hematology Oncology Journal2468-12452022-12-0174161164Langerhans cell histiocytosis of the cervical spine in a child: A case report and review of the literatureInes Trabelsi0Soumaya Kbaier1Samia Rekaya2Monia Ouederni3Samia Hamouda4Khedija Boussetta5Pediatrics Department B Children's Hospital of Tunis, Tunisia; University of Medicine, Tunis El Manar, Tunisia; Corresponding author. Pediatric Department B - Children's Hospital of Tunis Bab Saadoun-Jabbary, PC: 1007, Tunis, Tunisia University of Medicine of Tunis El Manar.Pediatrics Department B Children's Hospital of Tunis, Tunisia; University of Medicine, Tunis El Manar, TunisiaPediatric Immuno-hematology Unit, Bone Marrow Transplantation Center Tunis, Tunisia; University of Medicine, Tunis El Manar, TunisiaPediatric Immuno-hematology Unit, Bone Marrow Transplantation Center Tunis, Tunisia; University of Medicine, Tunis El Manar, TunisiaPediatrics Department B Children's Hospital of Tunis, Tunisia; University of Medicine, Tunis El Manar, TunisiaPediatrics Department B Children's Hospital of Tunis, Tunisia; University of Medicine, Tunis El Manar, TunisiaLangerhans cell histiocytosis (LCH) is a rare disorder of clonal proliferation of dendritic cell mostly seen in children. It consists in various clinical manifestations from a single lytic bone lesion to multisystemic lesions with organ dysfunction. Atlantoaxial involvement by LCH is very rare, especially in a young child. We report a rare case of the cervical spine LCH resulting in dragging torticollis as the first symptom lasting for 4 weeks in a 6-year-old boy. Histological features were consistent with the diagnosis. The patient received chemotherapy with steroids and he underwent a laminectomy with arthrodesis. He remained well with no evidence of recurrence during the follow-up period. The rarity of this disease as well as the site of bone involvement draws attention for early diagnosis to prevent neurological lesions and other late complications.http://www.sciencedirect.com/science/article/pii/S2468124522002492Langerhans cell histiocytosisTorticollisCervical spineChild |
| spellingShingle | Ines Trabelsi Soumaya Kbaier Samia Rekaya Monia Ouederni Samia Hamouda Khedija Boussetta Langerhans cell histiocytosis of the cervical spine in a child: A case report and review of the literature Pediatric Hematology Oncology Journal Langerhans cell histiocytosis Torticollis Cervical spine Child |
| title | Langerhans cell histiocytosis of the cervical spine in a child: A case report and review of the literature |
| title_full | Langerhans cell histiocytosis of the cervical spine in a child: A case report and review of the literature |
| title_fullStr | Langerhans cell histiocytosis of the cervical spine in a child: A case report and review of the literature |
| title_full_unstemmed | Langerhans cell histiocytosis of the cervical spine in a child: A case report and review of the literature |
| title_short | Langerhans cell histiocytosis of the cervical spine in a child: A case report and review of the literature |
| title_sort | langerhans cell histiocytosis of the cervical spine in a child a case report and review of the literature |
| topic | Langerhans cell histiocytosis Torticollis Cervical spine Child |
| url | http://www.sciencedirect.com/science/article/pii/S2468124522002492 |
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