β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications
Previous studies have found that β-Hydroxybutyrate (BHB), the main component of ketone bodies, is of physiological importance as a backup energy source during starvation or induces diabetic ketoacidosis when insulin deficiency occurs. Ketogenic diets (KD) have been used as metabolic therapy for over...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023083068 |
| _version_ | 1797429905717198848 |
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| author | Yanqiu He Xi Cheng Tingting Zhou Dongze Li Juan Peng Yong Xu Wei Huang |
| author_facet | Yanqiu He Xi Cheng Tingting Zhou Dongze Li Juan Peng Yong Xu Wei Huang |
| author_sort | Yanqiu He |
| collection | DOAJ |
| description | Previous studies have found that β-Hydroxybutyrate (BHB), the main component of ketone bodies, is of physiological importance as a backup energy source during starvation or induces diabetic ketoacidosis when insulin deficiency occurs. Ketogenic diets (KD) have been used as metabolic therapy for over a hundred years, it is well known that ketone bodies and BHB not only serve as ancillary fuel substituting for glucose but also induce anti-oxidative, anti-inflammatory, and cardioprotective features via binding to several target proteins, including histone deacetylase (HDAC), or G protein-coupled receptors (GPCRs). Recent advances in epigenetics, especially novel histone post-translational modifications (HPTMs), have continuously updated our understanding of BHB, which also acts as a signal transduction molecule and modification substrate to regulate a series of epigenetic phenomena, such as histone acetylation, histone β-hydroxybutyrylation, histone methylation, DNA methylation, and microRNAs. These epigenetic events alter the activity of genes without changing the DNA structure and further participate in the pathogenesis of related diseases. This review focuses on the metabolic process of BHB and BHB-mediated epigenetics in cardiovascular diseases, diabetes and complications of diabetes, neuropsychiatric diseases, cancers, osteoporosis, liver and kidney injury, embryonic and fetal development, and intestinal homeostasis, and discusses potential molecular mechanisms, drug targets, and application prospects. |
| first_indexed | 2024-03-09T09:21:03Z |
| format | Article |
| id | doaj.art-524b248d28f74e9abf3387e2c545d646 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:21:03Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-524b248d28f74e9abf3387e2c545d6462023-12-02T07:01:13ZengElsevierHeliyon2405-84402023-11-01911e21098β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implicationsYanqiu He0Xi Cheng1Tingting Zhou2Dongze Li3Juan Peng4Yong Xu5Wei Huang6Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, 646000, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, 646000, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, 646000, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, 646000, ChinaDepartment of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, ChinaDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, 646000, China; Corresponding author. Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Metabolic Vascular Diseases Key Laboratory of Sichuan Province, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolic Diseases, Luzhou, Sichuan, 646000, China; Corresponding author. Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.Previous studies have found that β-Hydroxybutyrate (BHB), the main component of ketone bodies, is of physiological importance as a backup energy source during starvation or induces diabetic ketoacidosis when insulin deficiency occurs. Ketogenic diets (KD) have been used as metabolic therapy for over a hundred years, it is well known that ketone bodies and BHB not only serve as ancillary fuel substituting for glucose but also induce anti-oxidative, anti-inflammatory, and cardioprotective features via binding to several target proteins, including histone deacetylase (HDAC), or G protein-coupled receptors (GPCRs). Recent advances in epigenetics, especially novel histone post-translational modifications (HPTMs), have continuously updated our understanding of BHB, which also acts as a signal transduction molecule and modification substrate to regulate a series of epigenetic phenomena, such as histone acetylation, histone β-hydroxybutyrylation, histone methylation, DNA methylation, and microRNAs. These epigenetic events alter the activity of genes without changing the DNA structure and further participate in the pathogenesis of related diseases. This review focuses on the metabolic process of BHB and BHB-mediated epigenetics in cardiovascular diseases, diabetes and complications of diabetes, neuropsychiatric diseases, cancers, osteoporosis, liver and kidney injury, embryonic and fetal development, and intestinal homeostasis, and discusses potential molecular mechanisms, drug targets, and application prospects.http://www.sciencedirect.com/science/article/pii/S2405844023083068β-hydroxybutyrateEpigeneticsHistone post-translational modificationKetogenic dietDNA methylationmicroRNAs |
| spellingShingle | Yanqiu He Xi Cheng Tingting Zhou Dongze Li Juan Peng Yong Xu Wei Huang β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications Heliyon β-hydroxybutyrate Epigenetics Histone post-translational modification Ketogenic diet DNA methylation microRNAs |
| title | β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications |
| title_full | β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications |
| title_fullStr | β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications |
| title_full_unstemmed | β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications |
| title_short | β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications |
| title_sort | β hydroxybutyrate as an epigenetic modifier underlying mechanisms and implications |
| topic | β-hydroxybutyrate Epigenetics Histone post-translational modification Ketogenic diet DNA methylation microRNAs |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023083068 |
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