ROLE OF MONOCYTES IN PATHOGENESIS OF GENERALIZED PERITONITIS
Objective: To study the sepsis markers informativeness to assess the role of monocytes in the pathogenesis of generalized peritonitis (GP). Methods: The study included 160 patients with GP, who were divided into 3 groups, according to the stages of the disease. To establish the activity of monocy...
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| Format: | Article |
| Language: | English |
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Avicenna Tajik State Medical University
2020-09-01
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| Series: | Паёми Сино |
| Subjects: | |
| Online Access: | https://doi.org/10.25005/2074-0581-2020-22-3-455-460 |
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| author | A.R. SARAEV SH.K. NAZAROV S.G. ALI-ZADE |
| author_facet | A.R. SARAEV SH.K. NAZAROV S.G. ALI-ZADE |
| author_sort | A.R. SARAEV |
| collection | DOAJ |
| description | Objective: To study the sepsis markers informativeness to assess the role of monocytes in the pathogenesis of generalized peritonitis (GP).
Methods: The study included 160 patients with GP, who were divided into 3 groups, according to the stages of the disease. To establish the activity of monocytes was made a determination of the level of cytokine TNF-α and presepsin in the blood.
Results: Studies showed that the level of TNF-α in patient with septic shock was reliably lower (24.5±13.3 pg/ml) than in patients with endogenous intoxication and abdominal sepsis. The value of TNF-α in deceased patients also was low – 4.8±0.9 pg/ml. This indicates a decrease in the ability of monocytes in GP at the stage of septic shock to exude a sufficient amount of pro-inflammatory cytokines in response to endotoxin aggression. The level of presepsin increased by stages and amounted to 355.6±8.6, 783.4±24.0 and 1587.7±70.5 pg/ml, respectively. This indicates the circulation in the blood of the CD14 receptor, which is able to express on monocytes, converting them into endothelial progenitor cells.
Conclusion: Monocytes as endothelial progenitor cells contribute to the regeneration and restoration of endothelial function in its dysfunction that develops in GP and abdominal sepsis. In consequence of developing immunosuppression and suppression of monocyte function in the stage of septic shock, the process of renewal of endothelial cells is weakened, the secretion of pro-inflammatory cytokines, in particular TNF-α, decreases, which can contribute to an increase in mortality in septic shock. |
| first_indexed | 2024-03-13T03:51:41Z |
| format | Article |
| id | doaj.art-524da28bd76d42b29b08c2c29e1f8750 |
| institution | Directory Open Access Journal |
| issn | 2074-0581 2959-6327 |
| language | English |
| last_indexed | 2024-03-13T03:51:41Z |
| publishDate | 2020-09-01 |
| publisher | Avicenna Tajik State Medical University |
| record_format | Article |
| series | Паёми Сино |
| spelling | doaj.art-524da28bd76d42b29b08c2c29e1f87502023-06-22T13:01:40ZengAvicenna Tajik State Medical UniversityПаёми Сино2074-05812959-63272020-09-0122345546010.25005/2074-0581-2020-22-3-455-460ROLE OF MONOCYTES IN PATHOGENESIS OF GENERALIZED PERITONITISA.R. SARAEV0SH.K. NAZAROV1S.G. ALI-ZADE2Department of Surgical Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of TajikistanDepartment of Surgical Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of TajikistanDepartment of Surgical Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of TajikistanObjective: To study the sepsis markers informativeness to assess the role of monocytes in the pathogenesis of generalized peritonitis (GP). Methods: The study included 160 patients with GP, who were divided into 3 groups, according to the stages of the disease. To establish the activity of monocytes was made a determination of the level of cytokine TNF-α and presepsin in the blood. Results: Studies showed that the level of TNF-α in patient with septic shock was reliably lower (24.5±13.3 pg/ml) than in patients with endogenous intoxication and abdominal sepsis. The value of TNF-α in deceased patients also was low – 4.8±0.9 pg/ml. This indicates a decrease in the ability of monocytes in GP at the stage of septic shock to exude a sufficient amount of pro-inflammatory cytokines in response to endotoxin aggression. The level of presepsin increased by stages and amounted to 355.6±8.6, 783.4±24.0 and 1587.7±70.5 pg/ml, respectively. This indicates the circulation in the blood of the CD14 receptor, which is able to express on monocytes, converting them into endothelial progenitor cells. Conclusion: Monocytes as endothelial progenitor cells contribute to the regeneration and restoration of endothelial function in its dysfunction that develops in GP and abdominal sepsis. In consequence of developing immunosuppression and suppression of monocyte function in the stage of septic shock, the process of renewal of endothelial cells is weakened, the secretion of pro-inflammatory cytokines, in particular TNF-α, decreases, which can contribute to an increase in mortality in septic shock.https://doi.org/10.25005/2074-0581-2020-22-3-455-460monocytesabdominal sepsisseptic shockendothelial dysfunctionprogenitor cells. |
| spellingShingle | A.R. SARAEV SH.K. NAZAROV S.G. ALI-ZADE ROLE OF MONOCYTES IN PATHOGENESIS OF GENERALIZED PERITONITIS Паёми Сино monocytes abdominal sepsis septic shock endothelial dysfunction progenitor cells. |
| title | ROLE OF MONOCYTES IN PATHOGENESIS OF GENERALIZED PERITONITIS |
| title_full | ROLE OF MONOCYTES IN PATHOGENESIS OF GENERALIZED PERITONITIS |
| title_fullStr | ROLE OF MONOCYTES IN PATHOGENESIS OF GENERALIZED PERITONITIS |
| title_full_unstemmed | ROLE OF MONOCYTES IN PATHOGENESIS OF GENERALIZED PERITONITIS |
| title_short | ROLE OF MONOCYTES IN PATHOGENESIS OF GENERALIZED PERITONITIS |
| title_sort | role of monocytes in pathogenesis of generalized peritonitis |
| topic | monocytes abdominal sepsis septic shock endothelial dysfunction progenitor cells. |
| url | https://doi.org/10.25005/2074-0581-2020-22-3-455-460 |
| work_keys_str_mv | AT arsaraev roleofmonocytesinpathogenesisofgeneralizedperitonitis AT shknazarov roleofmonocytesinpathogenesisofgeneralizedperitonitis AT sgalizade roleofmonocytesinpathogenesisofgeneralizedperitonitis |