Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China

Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China

ABSTRACT We reported a novel African swine fever virus (ASFV) strain that had a three-large-fragment deletion and unique variations in genome. This isolate displayed a nonhemadsorbing phenotype and had homogeneous proliferation compared with the wild-type ASFV strain. Our findings highlighted the ur...

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Bibliographic Details
Main Authors: Yankuo Sun, Zhiying Xu, Han Gao, Sijia Xu, Jing Liu, Jiabao Xing, Qiyuan Kuang, Yang Chen, Heng Wang, Guihong Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
African swine fever virus
large-fragment deletions
genomes
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02155-22
Description
Summary:ABSTRACT We reported a novel African swine fever virus (ASFV) strain that had a three-large-fragment deletion and unique variations in genome. This isolate displayed a nonhemadsorbing phenotype and had homogeneous proliferation compared with the wild-type ASFV strain. Our findings highlighted the urgent need for further investigation of ASFV variations in China. IMPORTANCE African swine fever virus (ASFV) has been circulating in China for 5 years, and low virulent strains with changes in the genome have been reported. Nevertheless, there is still a lack of knowledge about the epidemic strains at the whole-genome level. This study reported a novel strain and further analyzed its genomic and biological characteristics. In addition, our study also suggests that whole-genome sequencing plays a key role in the epidemiology investigation of ASFV variations.
ISSN:2165-0497

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