Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China
ABSTRACT We reported a novel African swine fever virus (ASFV) strain that had a three-large-fragment deletion and unique variations in genome. This isolate displayed a nonhemadsorbing phenotype and had homogeneous proliferation compared with the wild-type ASFV strain. Our findings highlighted the ur...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2022-10-01
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| Series: | Microbiology Spectrum |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/spectrum.02155-22 |
| _version_ | 1811329694610489344 |
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| author | Yankuo Sun Zhiying Xu Han Gao Sijia Xu Jing Liu Jiabao Xing Qiyuan Kuang Yang Chen Heng Wang Guihong Zhang |
| author_facet | Yankuo Sun Zhiying Xu Han Gao Sijia Xu Jing Liu Jiabao Xing Qiyuan Kuang Yang Chen Heng Wang Guihong Zhang |
| author_sort | Yankuo Sun |
| collection | DOAJ |
| description | ABSTRACT We reported a novel African swine fever virus (ASFV) strain that had a three-large-fragment deletion and unique variations in genome. This isolate displayed a nonhemadsorbing phenotype and had homogeneous proliferation compared with the wild-type ASFV strain. Our findings highlighted the urgent need for further investigation of ASFV variations in China. IMPORTANCE African swine fever virus (ASFV) has been circulating in China for 5 years, and low virulent strains with changes in the genome have been reported. Nevertheless, there is still a lack of knowledge about the epidemic strains at the whole-genome level. This study reported a novel strain and further analyzed its genomic and biological characteristics. In addition, our study also suggests that whole-genome sequencing plays a key role in the epidemiology investigation of ASFV variations. |
| first_indexed | 2024-04-13T15:48:36Z |
| format | Article |
| id | doaj.art-524dc921ad0d49c8b944d7f739bd2cb4 |
| institution | Directory Open Access Journal |
| issn | 2165-0497 |
| language | English |
| last_indexed | 2024-04-13T15:48:36Z |
| publishDate | 2022-10-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | Microbiology Spectrum |
| spelling | doaj.art-524dc921ad0d49c8b944d7f739bd2cb42022-12-22T02:40:54ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972022-10-0110510.1128/spectrum.02155-22Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, ChinaYankuo Sun0Zhiying Xu1Han Gao2Sijia Xu3Jing Liu4Jiabao Xing5Qiyuan Kuang6Yang Chen7Heng Wang8Guihong Zhang9African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaAfrican Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaAfrican Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaAfrican Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaAfrican Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaAfrican Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaAfrican Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaAfrican Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaAfrican Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaAfrican Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, ChinaABSTRACT We reported a novel African swine fever virus (ASFV) strain that had a three-large-fragment deletion and unique variations in genome. This isolate displayed a nonhemadsorbing phenotype and had homogeneous proliferation compared with the wild-type ASFV strain. Our findings highlighted the urgent need for further investigation of ASFV variations in China. IMPORTANCE African swine fever virus (ASFV) has been circulating in China for 5 years, and low virulent strains with changes in the genome have been reported. Nevertheless, there is still a lack of knowledge about the epidemic strains at the whole-genome level. This study reported a novel strain and further analyzed its genomic and biological characteristics. In addition, our study also suggests that whole-genome sequencing plays a key role in the epidemiology investigation of ASFV variations.https://journals.asm.org/doi/10.1128/spectrum.02155-22African swine fever viruslarge-fragment deletionsgenomes |
| spellingShingle | Yankuo Sun Zhiying Xu Han Gao Sijia Xu Jing Liu Jiabao Xing Qiyuan Kuang Yang Chen Heng Wang Guihong Zhang Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China Microbiology Spectrum African swine fever virus large-fragment deletions genomes |
| title | Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China |
| title_full | Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China |
| title_fullStr | Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China |
| title_full_unstemmed | Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China |
| title_short | Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China |
| title_sort | detection of a novel african swine fever virus with three large fragment deletions in genome china |
| topic | African swine fever virus large-fragment deletions genomes |
| url | https://journals.asm.org/doi/10.1128/spectrum.02155-22 |
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