Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis
Abstract Background Childhood obesity is one of the main concerns of public health. Considering its long-term adverse health effect, various studies investigated the effect of drug therapy on anthropometric parameters and provided mixed results. In this systematic review and meta-analysis, we aimed...
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| Format: | Article |
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BMC
2023-07-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-023-01390-7 |
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| author | Zeinab Nikniaz Leila Nikniaz Mahdieh Abbasalizad Farhangi Hossein Mehralizadeh Shabnam Salekzamani |
| author_facet | Zeinab Nikniaz Leila Nikniaz Mahdieh Abbasalizad Farhangi Hossein Mehralizadeh Shabnam Salekzamani |
| author_sort | Zeinab Nikniaz |
| collection | DOAJ |
| description | Abstract Background Childhood obesity is one of the main concerns of public health. Considering its long-term adverse health effect, various studies investigated the effect of drug therapy on anthropometric parameters and provided mixed results. In this systematic review and meta-analysis, we aimed to determine the effect of Orlistat on anthropometrics and biochemical parameters in children and adolescents. Materials and methods The databases of PubMed, Scopus, and Web of Science were searched until September 2022. Experimental and semi-experimental studies were included if they evaluated the effect of Orlistat on obesity-related parameters in children and reported the before and after anthropometric values. A revised Cochrane risk-of-bias (Rob2) was used to evaluate the methodological quality. STATA software version 16.0 was used for the meta-analysis of the random-effect model. Results Of 810 articles retrieved in the initial search, four experimental and two semi-experimental studies were selected for systematic review. The result of the meta-analysis of experimental studies indicated the significant effect of Orlistat on waist circumference (SMD: -0.27, 95% CI: -0.47, -0.07) and serum insulin level (SMD: -0.89, 95% CI: -1.52, 0.26). However, there were no significant effects of orlistat on body weight, body mass index, lipid profile, and serum glucose level. Conclusion The present meta-analysis showed the significant effect of Orlistat on the reduction of waist circumference and insulin level in overweight and obese adolescents. However, due to the paucity of studies included in the meta-analysis, more prospective studies with longer duration and more sample sizes will be needed in this age group. |
| first_indexed | 2024-03-13T00:41:33Z |
| format | Article |
| id | doaj.art-524fdd64ccd84495984161214018848c |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-13T00:41:33Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-524fdd64ccd84495984161214018848c2023-07-09T11:16:15ZengBMCBMC Endocrine Disorders1472-68232023-07-0123111210.1186/s12902-023-01390-7Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysisZeinab Nikniaz0Leila Nikniaz1Mahdieh Abbasalizad Farhangi2Hossein Mehralizadeh3Shabnam Salekzamani4Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical SciencesTabriz Health Services Management Research Center, Tabriz University of Medical SciencesCommunity Nutrition Department, Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesTabriz Health Services Management Research Center, Tabriz University of Medical SciencesAbstract Background Childhood obesity is one of the main concerns of public health. Considering its long-term adverse health effect, various studies investigated the effect of drug therapy on anthropometric parameters and provided mixed results. In this systematic review and meta-analysis, we aimed to determine the effect of Orlistat on anthropometrics and biochemical parameters in children and adolescents. Materials and methods The databases of PubMed, Scopus, and Web of Science were searched until September 2022. Experimental and semi-experimental studies were included if they evaluated the effect of Orlistat on obesity-related parameters in children and reported the before and after anthropometric values. A revised Cochrane risk-of-bias (Rob2) was used to evaluate the methodological quality. STATA software version 16.0 was used for the meta-analysis of the random-effect model. Results Of 810 articles retrieved in the initial search, four experimental and two semi-experimental studies were selected for systematic review. The result of the meta-analysis of experimental studies indicated the significant effect of Orlistat on waist circumference (SMD: -0.27, 95% CI: -0.47, -0.07) and serum insulin level (SMD: -0.89, 95% CI: -1.52, 0.26). However, there were no significant effects of orlistat on body weight, body mass index, lipid profile, and serum glucose level. Conclusion The present meta-analysis showed the significant effect of Orlistat on the reduction of waist circumference and insulin level in overweight and obese adolescents. However, due to the paucity of studies included in the meta-analysis, more prospective studies with longer duration and more sample sizes will be needed in this age group.https://doi.org/10.1186/s12902-023-01390-7OrlistatChildrenAdolescentsMetabolic IndicesAnthropometry |
| spellingShingle | Zeinab Nikniaz Leila Nikniaz Mahdieh Abbasalizad Farhangi Hossein Mehralizadeh Shabnam Salekzamani Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis BMC Endocrine Disorders Orlistat Children Adolescents Metabolic Indices Anthropometry |
| title | Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis |
| title_full | Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis |
| title_fullStr | Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis |
| title_full_unstemmed | Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis |
| title_short | Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis |
| title_sort | effect of orlistat on anthropometrics and metabolic indices in children and adolescents a systematic review and meta analysis |
| topic | Orlistat Children Adolescents Metabolic Indices Anthropometry |
| url | https://doi.org/10.1186/s12902-023-01390-7 |
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