Relationship between the volume of perivascular adipose tissue and the vascular wall lesion
Aim. To study the relationship between the volume of perivascular adipose tissue (PVAT) and the vascular wall lesion.Material and methods. The study included 318 patients without cardiovascular disease (mean age, 63,5±13,7 years). Hypertension was detected in 268 (84,3%) patients. All patients under...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2021-11-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2993 |
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| author | V. I. Podzolkov A. E. Bragina K. K. Osadchiy Yu. N. Rodionova Z. B. Jafarova M. V. Lobanova Yu. S. Larionova |
| author_facet | V. I. Podzolkov A. E. Bragina K. K. Osadchiy Yu. N. Rodionova Z. B. Jafarova M. V. Lobanova Yu. S. Larionova |
| author_sort | V. I. Podzolkov |
| collection | DOAJ |
| description | Aim. To study the relationship between the volume of perivascular adipose tissue (PVAT) and the vascular wall lesion.Material and methods. The study included 318 patients without cardiovascular disease (mean age, 63,5±13,7 years). Hypertension was detected in 268 (84,3%) patients. All patients underwent assessment of anthropometric characteristics, lipid profile, arterial wall stiffness with the estimation of cardio-ankle vascular index, intima-media thickness, brachial artery endothelial vasomotor function. Chest computed tomography was performed with the estimation of the volumes of PVAT and pericardial adipose tissue (PAT).Results. The volume of PVAT, on average, was 0,3 [0,2; 0,4] cm3 . The VAT volume was significantly higher in obese individuals when compared with patients with normal body weight: 0,4 [0,3; 0,5] vs 0,25 [0,2; 0,4] cm3 (p=0,0007). The VAT volume was higher in individuals with an increased CAVI level when compared with patients with normal CAVI values: 0,4 [0,3; 0,5] vs 0,3 [0,25; 0,3] (p=0,02). A significant correlation was found between the VAT volume and body mass index (r=0,27, p<0,005), waist circumference (r=0,41, p<0,005), CAVI (r=0,49, p<0,05), impaired endothelium-dependent brachial artery vasodilation (r=0,38, p<0,05). When performing multiple linear regression, a significant relationship of CAVI was found with age (β±SE, 0,51±0,15; p=0,002) and volume of PVAT (β±SE, 0,41±0,13; p=0,005).Conclusion. The results indicate the relationship of PVAT with visceral obesity and vascular wall stiffness parameters. |
| first_indexed | 2024-04-10T03:33:57Z |
| format | Article |
| id | doaj.art-5251bc2705e64738952718898a78c38d |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:33:57Z |
| publishDate | 2021-11-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-5251bc2705e64738952718898a78c38d2023-03-13T07:23:31Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252021-11-0120710.15829/1728-8800-2021-29932374Relationship between the volume of perivascular adipose tissue and the vascular wall lesionV. I. Podzolkov0A. E. Bragina1K. K. Osadchiy2Yu. N. Rodionova3Z. B. Jafarova4M. V. Lobanova5Yu. S. Larionova6ФГАОУ ВО Первый Московский государственный медицинский университет им.И.М.Сеченова (Семеновский Университет)ФГАОУ ВО Первый Московский государственный медицинский университет им.И.М.Сеченова (Семеновский Университет)ФГАОУ ВО Первый Московский государственный медицинский университет им.И.М.Сеченова (Семеновский Университет)ФГАОУ ВО Первый Московский государственный медицинский университет им.И.М.Сеченова (Семеновский Университет)ФГАОУ ВО Первый Московский государственный медицинский университет им.И.М.Сеченова (Семеновский Университет)ФГАОУ ВО Первый Московский государственный медицинский университет им.И.М.Сеченова (Семеновский Университет)ФГАОУ ВО Первый Московский государственный медицинский университет им.И.М.Сеченова (Семеновский Университет)Aim. To study the relationship between the volume of perivascular adipose tissue (PVAT) and the vascular wall lesion.Material and methods. The study included 318 patients without cardiovascular disease (mean age, 63,5±13,7 years). Hypertension was detected in 268 (84,3%) patients. All patients underwent assessment of anthropometric characteristics, lipid profile, arterial wall stiffness with the estimation of cardio-ankle vascular index, intima-media thickness, brachial artery endothelial vasomotor function. Chest computed tomography was performed with the estimation of the volumes of PVAT and pericardial adipose tissue (PAT).Results. The volume of PVAT, on average, was 0,3 [0,2; 0,4] cm3 . The VAT volume was significantly higher in obese individuals when compared with patients with normal body weight: 0,4 [0,3; 0,5] vs 0,25 [0,2; 0,4] cm3 (p=0,0007). The VAT volume was higher in individuals with an increased CAVI level when compared with patients with normal CAVI values: 0,4 [0,3; 0,5] vs 0,3 [0,25; 0,3] (p=0,02). A significant correlation was found between the VAT volume and body mass index (r=0,27, p<0,005), waist circumference (r=0,41, p<0,005), CAVI (r=0,49, p<0,05), impaired endothelium-dependent brachial artery vasodilation (r=0,38, p<0,05). When performing multiple linear regression, a significant relationship of CAVI was found with age (β±SE, 0,51±0,15; p=0,002) and volume of PVAT (β±SE, 0,41±0,13; p=0,005).Conclusion. The results indicate the relationship of PVAT with visceral obesity and vascular wall stiffness parameters.https://cardiovascular.elpub.ru/jour/article/view/2993сердечно-сосудистые заболеванияпериваскулярная жировая тканьжесткость сосудистой стенкисиндром раннего сосудистого старенияартериальная гипертензияперикардиальная жировая ткань |
| spellingShingle | V. I. Podzolkov A. E. Bragina K. K. Osadchiy Yu. N. Rodionova Z. B. Jafarova M. V. Lobanova Yu. S. Larionova Relationship between the volume of perivascular adipose tissue and the vascular wall lesion Кардиоваскулярная терапия и профилактика сердечно-сосудистые заболевания периваскулярная жировая ткань жесткость сосудистой стенки синдром раннего сосудистого старения артериальная гипертензия перикардиальная жировая ткань |
| title | Relationship between the volume of perivascular adipose tissue and the vascular wall lesion |
| title_full | Relationship between the volume of perivascular adipose tissue and the vascular wall lesion |
| title_fullStr | Relationship between the volume of perivascular adipose tissue and the vascular wall lesion |
| title_full_unstemmed | Relationship between the volume of perivascular adipose tissue and the vascular wall lesion |
| title_short | Relationship between the volume of perivascular adipose tissue and the vascular wall lesion |
| title_sort | relationship between the volume of perivascular adipose tissue and the vascular wall lesion |
| topic | сердечно-сосудистые заболевания периваскулярная жировая ткань жесткость сосудистой стенки синдром раннего сосудистого старения артериальная гипертензия перикардиальная жировая ткань |
| url | https://cardiovascular.elpub.ru/jour/article/view/2993 |
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