Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)
Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan. The latter includes two distinct ALS/PDC-affected regions (H...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-03-01
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| Series: | eNeurologicalSci |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405650220300095 |
| _version_ | 1818033160175222784 |
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| author | Peter S. Spencer Valerie S. Palmer Tameko Kihira Sohei Yoshida Jacques Reis Momoko Yabushita Yoshiro Yase |
| author_facet | Peter S. Spencer Valerie S. Palmer Tameko Kihira Sohei Yoshida Jacques Reis Momoko Yabushita Yoshiro Yase |
| author_sort | Peter S. Spencer |
| collection | DOAJ |
| description | Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan. The latter includes two distinct ALS/PDC-affected regions (Hohara and Kozagawa), where the disorder is known as Muro disease. In Hohara, oral exposure to plant (cycad) neurotoxins used in traditional medical practice has been linked previously to Muro disease. We report new observations that link Kampō medicine to Muro disease in the southern Kozagawa focus. Oral exposure to cycad seed toxins is associated with all three foci of Western Pacific ALS/PDC. Keywords: Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex, Kii peninsula, Honshu, Japan, Traditional/folk medical practice, Cycad seed, Sotetsu |
| first_indexed | 2024-12-10T06:18:51Z |
| format | Article |
| id | doaj.art-525204e83d6d421d8bcc2adb8041b7df |
| institution | Directory Open Access Journal |
| issn | 2405-6502 |
| language | English |
| last_indexed | 2024-12-10T06:18:51Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | eNeurologicalSci |
| spelling | doaj.art-525204e83d6d421d8bcc2adb8041b7df2022-12-22T01:59:23ZengElseviereNeurologicalSci2405-65022020-03-0118Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)Peter S. Spencer0Valerie S. Palmer1Tameko Kihira2Sohei Yoshida3Jacques Reis4Momoko Yabushita5Yoshiro Yase6Oregon Health & Science University, Portland, Oregon, USA; Corresponding author at: Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA.Oregon Health & Science University, Portland, Oregon, USAKansai University of Health Sciences, JapanKansai University of Health Sciences, JapanUniversity of Strasbourg, Strasbourg, FranceNagoya University, Nagoya, JapanWakayama Medical University, Wakayama, JapanWestern Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan. The latter includes two distinct ALS/PDC-affected regions (Hohara and Kozagawa), where the disorder is known as Muro disease. In Hohara, oral exposure to plant (cycad) neurotoxins used in traditional medical practice has been linked previously to Muro disease. We report new observations that link Kampō medicine to Muro disease in the southern Kozagawa focus. Oral exposure to cycad seed toxins is associated with all three foci of Western Pacific ALS/PDC. Keywords: Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex, Kii peninsula, Honshu, Japan, Traditional/folk medical practice, Cycad seed, Sotetsuhttp://www.sciencedirect.com/science/article/pii/S2405650220300095 |
| spellingShingle | Peter S. Spencer Valerie S. Palmer Tameko Kihira Sohei Yoshida Jacques Reis Momoko Yabushita Yoshiro Yase Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex) eNeurologicalSci |
| title | Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex) |
| title_full | Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex) |
| title_fullStr | Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex) |
| title_full_unstemmed | Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex) |
| title_short | Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex) |
| title_sort | kampo medicine and muro disease amyotrophic lateral sclerosis and parkinsonism dementia complex |
| url | http://www.sciencedirect.com/science/article/pii/S2405650220300095 |
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