Lower peripheral helper T cell levels in the synovium are associated with a better response to anti-TNF therapy in rheumatoid arthritis

Lower peripheral helper T cell levels in the synovium are associated with a better response to anti-TNF therapy in rheumatoid arthritis

Abstract Background The mechanisms by which only some rheumatoid arthritis (RA) patients respond favorably to TNF blockade are still poorly characterized. The goal of this study was to identify biological features that explain this differential response using a multilevel transcriptome analysis of t...

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Bibliographic Details
Main Authors: Antonio Julià, Gabriela Ávila, Raquel Celis, Raimon Sanmartí, Julio Ramírez, Sara Marsal, Juan D. Cañete
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Anti-TNF therapy
Synovial membrane
Clinical response
Deconvolution
Peripheral T helper
Online Access:http://link.springer.com/article/10.1186/s13075-020-02287-9

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