Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study
BackgroundWhether left ventricular non-compaction (LVNC) bears a different prognosis than dilated cardiomyopathy (DCM) is still a matter of debate.MethodsFrom a multicenter French prospective registry, we compared the outcomes of 98 patients with LVNC and 65 with DCM. The primary endpoint combined c...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.856160/full |
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| author | Hilla Gerard Nicolas Iline Hélène Martel Karine Nguyen Karine Nguyen Pascale Richard Pascale Richard Erwan Donal Jean-Christophe Eicher Olivier Huttin Christine Selton-Suty Pascale Raud-Raynier Guillaume Jondeau Nicolas Mansencal Caroline Sawka Flavie Ader Flavie Ader Jean-François Pruny Anne-Claire Casalta Nicolas Michel Valeria Donghi Laurence Faivre Roch Giorgi Philippe Charron Philippe Charron Gilbert Habib Gilbert Habib |
| author_facet | Hilla Gerard Nicolas Iline Hélène Martel Karine Nguyen Karine Nguyen Pascale Richard Pascale Richard Erwan Donal Jean-Christophe Eicher Olivier Huttin Christine Selton-Suty Pascale Raud-Raynier Guillaume Jondeau Nicolas Mansencal Caroline Sawka Flavie Ader Flavie Ader Jean-François Pruny Anne-Claire Casalta Nicolas Michel Valeria Donghi Laurence Faivre Roch Giorgi Philippe Charron Philippe Charron Gilbert Habib Gilbert Habib |
| author_sort | Hilla Gerard |
| collection | DOAJ |
| description | BackgroundWhether left ventricular non-compaction (LVNC) bears a different prognosis than dilated cardiomyopathy (DCM) is still a matter of debate.MethodsFrom a multicenter French prospective registry, we compared the outcomes of 98 patients with LVNC and 65 with DCM. The primary endpoint combined cardiovascular death, heart transplantation, and hospitalization for cardiovascular events. The two groups presented similar outcomes but different left ventricular ejection fractions (LVEF) (43.3% in LVNC vs. 35.95% in DCM, p = 0.001). For this reason, a subgroup analysis was performed comparing only patients with LVEF ≤ 45%, including 56 with LVNC and 49 with DCM.ResultsAmong patients with LVEF≤ 45%, at 5-year follow-up, the primary endpoint occurred in 33 (58.9%) among 56 patients with LVNC and 18 (36.7%) among 49 patients with DCM (p = 0.02). Hospitalization for heart failure (18 [32.14%] vs. 5 [10.20%], p = 0.035) and heart transplantation were more frequent in the LVNC than in the DCM group. The incidences of rhythmic complications (24 [42.85%] vs. 12 [24.48%], p = 0.17), embolic events, and cardiovascular death were similar between LVNC and DCM cases. Among the 42 patients with LVNC and LVEF > 45%, the primary endpoints occurred in only 4 (9.52%) patients, including 2 hospitalizations for heart failure and 3 rhythmic complications, but no embolic events.ConclusionIn this prospective cohort, patients with LVNC who have left ventricular dysfunction present a poorer prognosis than DCM patients. Heart failure events were especially more frequent, but embolic events were not. Patients with LVNC and preserved ejection fraction present very few events in 5 years. |
| first_indexed | 2024-12-10T12:26:37Z |
| format | Article |
| id | doaj.art-5253958da73a4e20b1bc35af2a0abc1e |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-10T12:26:37Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-5253958da73a4e20b1bc35af2a0abc1e2022-12-22T01:48:57ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-05-01910.3389/fcvm.2022.856160856160Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric StudyHilla Gerard0Nicolas Iline1Hélène Martel2Karine Nguyen3Karine Nguyen4Pascale Richard5Pascale Richard6Erwan Donal7Jean-Christophe Eicher8Olivier Huttin9Christine Selton-Suty10Pascale Raud-Raynier11Guillaume Jondeau12Nicolas Mansencal13Caroline Sawka14Flavie Ader15Flavie Ader16Jean-François Pruny17Anne-Claire Casalta18Nicolas Michel19Valeria Donghi20Laurence Faivre21Roch Giorgi22Philippe Charron23Philippe Charron24Gilbert Habib25Gilbert Habib26Cardiology Department, Assistance Publique Hopitaux de Marseille (APHM), La Timone Hospital, Marseille, FranceAssistance Publique Hopitaux de Marseille (APHM), Hop Timone, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Marseille, FranceCardiology Department, Assistance Publique Hopitaux de Marseille (APHM), La Timone Hospital, Marseille, FranceDépartement de génétique médicale, Assistance Publique Hopitaux de Marseille (APHM), Hôpital d'enfants de la Timone, Marseille, FranceAix Marseille University, INSERM, Marseille Medical Genetics, Faculté de Médecine, Marseille, FranceAssistance Publique Hopitaux de Paris (APHP), Functional Unit of Cardiogénétique et Myogénétique, Service de Biochimie Métabolique, Hôpitaux Universitaires de la Pitié-Salpêtrière-Charles Foix, Paris, FranceSorbonne Universités, INSERM, UMR_S 1166 and ICAN Institute for Cardiometabolism and Nutrition, Paris, FranceService de Cardiologie, Centre Hospitalier Régional Universitaire Pontchaillou, Rennes, FranceService de Cardiologie, CHU Dijon Bourgogne - Hôpital François Mitterrand, Dijon, FranceService de Cardiologie, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre-lès-Nancy, FranceService de Cardiologie, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre-lès-Nancy, France0Service de Cardiologie, CHU de Poitiers, Poitiers, France1Assistance Publique Hopitaux de Paris (APHP), Service Cardiologie, CHU Paris Nord- Val de Seine - Hôpital Xavier Bichat-Claude-Bernard, Paris, France2Assistance Publique Hopitaux de Paris (APHP), Service de Cardiologie, CHU Ambroise Paré, Boulogne Billancourt, France3Centre de génétique et FHU TRANSLAD, Hôpital d'Enfants et Université de Bourgogne, Dijon, FranceAssistance Publique Hopitaux de Paris (APHP), Functional Unit of Cardiogénétique et Myogénétique, Service de Biochimie Métabolique, Hôpitaux Universitaires de la Pitié-Salpêtrière-Charles Foix, Paris, FranceSorbonne Universités, INSERM, UMR_S 1166 and ICAN Institute for Cardiometabolism and Nutrition, Paris, France4Assistance Publique Hopitaux de Paris (APHP), Centre de Référence pour les Maladies Cardiaques Héréditaires, Hôpital Pitié- Salpêtrière, Paris, FranceCardiology Department, Assistance Publique Hopitaux de Marseille (APHM), La Timone Hospital, Marseille, FranceCardiology Department, Assistance Publique Hopitaux de Marseille (APHM), La Timone Hospital, Marseille, FranceCardiology Department, Assistance Publique Hopitaux de Marseille (APHM), La Timone Hospital, Marseille, France3Centre de génétique et FHU TRANSLAD, Hôpital d'Enfants et Université de Bourgogne, Dijon, France5Aix Marseille Univ, Assistance Publique Hopitaux de Marseille (APHM), INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, Hop Timone, BioSTIC, Biostatistique et Technologies de l'Information et de la Communication, Marseille, FranceAssistance Publique Hopitaux de Paris (APHP), Functional Unit of Cardiogénétique et Myogénétique, Service de Biochimie Métabolique, Hôpitaux Universitaires de la Pitié-Salpêtrière-Charles Foix, Paris, France4Assistance Publique Hopitaux de Paris (APHP), Centre de Référence pour les Maladies Cardiaques Héréditaires, Hôpital Pitié- Salpêtrière, Paris, FranceCardiology Department, Assistance Publique Hopitaux de Marseille (APHM), La Timone Hospital, Marseille, France6Aix Marseille Univ, IRD, Assistance Publique Hopitaux de Marseille (APHM), MEPHI, IHU-Méditerranée Infection, Marseille, FranceBackgroundWhether left ventricular non-compaction (LVNC) bears a different prognosis than dilated cardiomyopathy (DCM) is still a matter of debate.MethodsFrom a multicenter French prospective registry, we compared the outcomes of 98 patients with LVNC and 65 with DCM. The primary endpoint combined cardiovascular death, heart transplantation, and hospitalization for cardiovascular events. The two groups presented similar outcomes but different left ventricular ejection fractions (LVEF) (43.3% in LVNC vs. 35.95% in DCM, p = 0.001). For this reason, a subgroup analysis was performed comparing only patients with LVEF ≤ 45%, including 56 with LVNC and 49 with DCM.ResultsAmong patients with LVEF≤ 45%, at 5-year follow-up, the primary endpoint occurred in 33 (58.9%) among 56 patients with LVNC and 18 (36.7%) among 49 patients with DCM (p = 0.02). Hospitalization for heart failure (18 [32.14%] vs. 5 [10.20%], p = 0.035) and heart transplantation were more frequent in the LVNC than in the DCM group. The incidences of rhythmic complications (24 [42.85%] vs. 12 [24.48%], p = 0.17), embolic events, and cardiovascular death were similar between LVNC and DCM cases. Among the 42 patients with LVNC and LVEF > 45%, the primary endpoints occurred in only 4 (9.52%) patients, including 2 hospitalizations for heart failure and 3 rhythmic complications, but no embolic events.ConclusionIn this prospective cohort, patients with LVNC who have left ventricular dysfunction present a poorer prognosis than DCM patients. Heart failure events were especially more frequent, but embolic events were not. Patients with LVNC and preserved ejection fraction present very few events in 5 years.https://www.frontiersin.org/articles/10.3389/fcvm.2022.856160/fullleft ventricular non-compactionprognosisdilated cardiomyopathy registryregistryheart failure |
| spellingShingle | Hilla Gerard Nicolas Iline Hélène Martel Karine Nguyen Karine Nguyen Pascale Richard Pascale Richard Erwan Donal Jean-Christophe Eicher Olivier Huttin Christine Selton-Suty Pascale Raud-Raynier Guillaume Jondeau Nicolas Mansencal Caroline Sawka Flavie Ader Flavie Ader Jean-François Pruny Anne-Claire Casalta Nicolas Michel Valeria Donghi Laurence Faivre Roch Giorgi Philippe Charron Philippe Charron Gilbert Habib Gilbert Habib Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study Frontiers in Cardiovascular Medicine left ventricular non-compaction prognosis dilated cardiomyopathy registry registry heart failure |
| title | Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study |
| title_full | Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study |
| title_fullStr | Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study |
| title_full_unstemmed | Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study |
| title_short | Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study |
| title_sort | prognosis of adults with isolated left ventricular non compaction results of a prospective multicentric study |
| topic | left ventricular non-compaction prognosis dilated cardiomyopathy registry registry heart failure |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.856160/full |
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