Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet’s induced membrane in rats
Bone grafts: improving chances of graft acceptance Repairs to serious bone injuries may be improved by blocking a signaling pathway that causes newly forming membranes to fail. Masquelet’s technique involves placing acrylic spacers in areas of bone damage, inducing the formation of vascularised memb...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-04-01
|
| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-018-0062-9 |
| _version_ | 1818382185560801280 |
|---|---|
| author | Qian Tang Haimin Jin Minji Tong Gang Zheng Zhongjie Xie Shangkun Tang Jialei Jin Ping Shang Huazi Xu Liyan Shen Yu Zhang Haixiao Liu |
| author_facet | Qian Tang Haimin Jin Minji Tong Gang Zheng Zhongjie Xie Shangkun Tang Jialei Jin Ping Shang Huazi Xu Liyan Shen Yu Zhang Haixiao Liu |
| author_sort | Qian Tang |
| collection | DOAJ |
| description | Bone grafts: improving chances of graft acceptance Repairs to serious bone injuries may be improved by blocking a signaling pathway that causes newly forming membranes to fail. Masquelet’s technique involves placing acrylic spacers in areas of bone damage, inducing the formation of vascularised membranes which encourage the body to accept bone grafts. However, sometimes Masquelet’s membranes do not form correctly, leading to weaknesses in bone repairs and potential graft rejection. In experiments on rats, Qian Tang from Wenzhou Medical University, China, and coworkers found that a particular signaling pathway, D114/Notch1, was upregulated around 6 weeks post-operation, reducing blood vessel density and limiting new vessel growth, weakening the membranes. The team inhibited this pathway using an existing therapy that prevents blood clots. This treatment improved bone repairs by promoting the formation and function of blood vessels in membranes. |
| first_indexed | 2024-12-14T02:46:27Z |
| format | Article |
| id | doaj.art-52540421e6804153b24b61ab77f950b8 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-12-14T02:46:27Z |
| publishDate | 2018-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-52540421e6804153b24b61ab77f950b82022-12-21T23:19:53ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132018-04-0150411510.1038/s12276-018-0062-9Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet’s induced membrane in ratsQian Tang0Haimin Jin1Minji Tong2Gang Zheng3Zhongjie Xie4Shangkun Tang5Jialei Jin6Ping Shang7Huazi Xu8Liyan Shen9Yu Zhang10Haixiao Liu11Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Rehabilitation, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityBone grafts: improving chances of graft acceptance Repairs to serious bone injuries may be improved by blocking a signaling pathway that causes newly forming membranes to fail. Masquelet’s technique involves placing acrylic spacers in areas of bone damage, inducing the formation of vascularised membranes which encourage the body to accept bone grafts. However, sometimes Masquelet’s membranes do not form correctly, leading to weaknesses in bone repairs and potential graft rejection. In experiments on rats, Qian Tang from Wenzhou Medical University, China, and coworkers found that a particular signaling pathway, D114/Notch1, was upregulated around 6 weeks post-operation, reducing blood vessel density and limiting new vessel growth, weakening the membranes. The team inhibited this pathway using an existing therapy that prevents blood clots. This treatment improved bone repairs by promoting the formation and function of blood vessels in membranes.https://doi.org/10.1038/s12276-018-0062-9 |
| spellingShingle | Qian Tang Haimin Jin Minji Tong Gang Zheng Zhongjie Xie Shangkun Tang Jialei Jin Ping Shang Huazi Xu Liyan Shen Yu Zhang Haixiao Liu Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet’s induced membrane in rats Experimental and Molecular Medicine |
| title | Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet’s induced membrane in rats |
| title_full | Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet’s induced membrane in rats |
| title_fullStr | Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet’s induced membrane in rats |
| title_full_unstemmed | Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet’s induced membrane in rats |
| title_short | Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet’s induced membrane in rats |
| title_sort | inhibition of dll4 notch1 pathway promotes angiogenesis of masquelet s induced membrane in rats |
| url | https://doi.org/10.1038/s12276-018-0062-9 |
| work_keys_str_mv | AT qiantang inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT haiminjin inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT minjitong inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT gangzheng inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT zhongjiexie inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT shangkuntang inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT jialeijin inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT pingshang inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT huazixu inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT liyanshen inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT yuzhang inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats AT haixiaoliu inhibitionofdll4notch1pathwaypromotesangiogenesisofmasqueletsinducedmembraneinrats |