ALK1 Gene Rearranged Pulmonary Sarcomatoid Carcinoma Masquerading as Tuberculosis in a Young Male
Pulmonary sarcomatoid carcinoma is rare, with limited treatment options and poor prognosis. In contrast to other non small cell lung carcinomas, not much is known about its molecular biology. In an endemic country like India, lung cancer is often masked by tuberculosis and presents in advanced stage...
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| Format: | Article |
| Language: | English |
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Federation of Turkish Pathology Societies
2021-01-01
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| Series: | Türk Patoloji Dergisi |
| Subjects: | |
| Online Access: |
http://www.turkjpath.org/pdf.php3?id=1918
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| _version_ | 1797906871250583552 |
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| author | Ayushi SAHAY Rajiv KUMAR Amit JANU Kumar PRABHASH |
| author_facet | Ayushi SAHAY Rajiv KUMAR Amit JANU Kumar PRABHASH |
| author_sort | Ayushi SAHAY |
| collection | DOAJ |
| description | Pulmonary sarcomatoid carcinoma is rare, with limited treatment options and poor prognosis. In contrast to other non small cell lung carcinomas, not much is known about its molecular biology. In an endemic country like India, lung cancer is often masked by tuberculosis and presents in advanced stages. We report here an unusual case of pulmonary sarcomatoid carcinoma, in a young non-smoker male, who had co-existent tuberculosis masking and delaying the diagnosis of malignancy. On molecular study, the tumor showed ALK gene rearrangement, both by immunohistochemistry and fluorescence in-situ hybridization, which has been reported only twice previously. Presence of ALK gene rearrangements in sarcomatoid carcinoma has significant therapeutic implications and potential for altering the prognosis of this fatal disease. Hence we recommend performing ALK gene rearrangement analysis in all cases of sarcomatoid lung carcinomas. The report discusses the diagnostic approach and provides insight into the molecular pathogenesis of this exceedingly rare malignancy. |
| first_indexed | 2024-04-10T10:28:39Z |
| format | Article |
| id | doaj.art-525565177bb942cf87227db66b04c53a |
| institution | Directory Open Access Journal |
| issn | 1018-5615 1309-5730 |
| language | English |
| last_indexed | 2024-04-10T10:28:39Z |
| publishDate | 2021-01-01 |
| publisher | Federation of Turkish Pathology Societies |
| record_format | Article |
| series | Türk Patoloji Dergisi |
| spelling | doaj.art-525565177bb942cf87227db66b04c53a2023-02-15T16:21:16ZengFederation of Turkish Pathology SocietiesTürk Patoloji Dergisi1018-56151309-57302021-01-0137107107710.5146/tjpath.2020.01481ALK1 Gene Rearranged Pulmonary Sarcomatoid Carcinoma Masquerading as Tuberculosis in a Young MaleAyushi SAHAYRajiv KUMARAmit JANUKumar PRABHASHPulmonary sarcomatoid carcinoma is rare, with limited treatment options and poor prognosis. In contrast to other non small cell lung carcinomas, not much is known about its molecular biology. In an endemic country like India, lung cancer is often masked by tuberculosis and presents in advanced stages. We report here an unusual case of pulmonary sarcomatoid carcinoma, in a young non-smoker male, who had co-existent tuberculosis masking and delaying the diagnosis of malignancy. On molecular study, the tumor showed ALK gene rearrangement, both by immunohistochemistry and fluorescence in-situ hybridization, which has been reported only twice previously. Presence of ALK gene rearrangements in sarcomatoid carcinoma has significant therapeutic implications and potential for altering the prognosis of this fatal disease. Hence we recommend performing ALK gene rearrangement analysis in all cases of sarcomatoid lung carcinomas. The report discusses the diagnostic approach and provides insight into the molecular pathogenesis of this exceedingly rare malignancy. http://www.turkjpath.org/pdf.php3?id=1918 pulmonary sarcomatoid carcinomapulmonary tuberculosisalk gene rearrangementlung cancercrizotinib |
| spellingShingle | Ayushi SAHAY Rajiv KUMAR Amit JANU Kumar PRABHASH ALK1 Gene Rearranged Pulmonary Sarcomatoid Carcinoma Masquerading as Tuberculosis in a Young Male Türk Patoloji Dergisi pulmonary sarcomatoid carcinoma pulmonary tuberculosis alk gene rearrangement lung cancer crizotinib |
| title | ALK1 Gene Rearranged Pulmonary Sarcomatoid Carcinoma Masquerading as Tuberculosis in a Young Male |
| title_full | ALK1 Gene Rearranged Pulmonary Sarcomatoid Carcinoma Masquerading as Tuberculosis in a Young Male |
| title_fullStr | ALK1 Gene Rearranged Pulmonary Sarcomatoid Carcinoma Masquerading as Tuberculosis in a Young Male |
| title_full_unstemmed | ALK1 Gene Rearranged Pulmonary Sarcomatoid Carcinoma Masquerading as Tuberculosis in a Young Male |
| title_short | ALK1 Gene Rearranged Pulmonary Sarcomatoid Carcinoma Masquerading as Tuberculosis in a Young Male |
| title_sort | alk1 gene rearranged pulmonary sarcomatoid carcinoma masquerading as tuberculosis in a young male |
| topic | pulmonary sarcomatoid carcinoma pulmonary tuberculosis alk gene rearrangement lung cancer crizotinib |
| url |
http://www.turkjpath.org/pdf.php3?id=1918
|
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