Pseudomonas aeruginosa GidA modulates the expression of catalases at the posttranscriptional level and plays a role in virulence

Pseudomonas aeruginosa GidA modulates the expression of catalases at the posttranscriptional level and plays a role in virulence

Pseudomonas aeruginosa gidA, which encodes a putative tRNA-modifying enzyme, is associated with a variety of virulence phenotypes. Here, we demonstrated that P. aeruginosa gidA is responsible for the modifications of uridine in tRNAs in vivo. Loss of gidA was found to have no impact on the mRNA leve...

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Bibliographic Details
Main Authors: Thanyaporn Srimahaeak, Narumon Thongdee, Jurairat Chittrakanwong, Sopapan Atichartpongkul, Juthamas Jaroensuk, Kamonwan Phatinuwat, Narumon Phaonakrop, Janthima Jaresitthikunchai, Sittiruk Roytrakul, Skorn Mongkolsuk, Mayuree Fuangthong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
Pseudomonas aeruginosa
tRNA modification
oxidative stress
gidA
U34 modification
catalases
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1079710/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1079710/full

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