Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea

Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea

Hearing loss is a problem that impacts a significant proportion of the adult population. Cochlear hair cell (HC) loss due to loud noise, chemotherapy and aging is the major underlying cause. A significant proportion of these individuals are dissatisfied with available treatment options which include...

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Bibliographic Details
Main Authors: Michael Hoa, Rafal Olszewski, Xiaoyi Li, Ian Taukulis, Shoujun Gu, Alvin DeTorres, Ivan A. Lopez, Fred H. Linthicum Jr., Akira Ishiyama, Daniel Martin, Robert J. Morell, Matthew W. Kelley
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
inner ear
supporting cell subtypes
smFISH
adult (MeSH)
cell cycle
FACS
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00013/full

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