Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome
Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patien...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-12-01
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| Series: | Hematology Reports |
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| Online Access: | http://www.pagepress.org/journals/index.php/hr/article/view/2190 |
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| author | Vanya Slavcheva T. Lukanov G. Balatsenko S. Angelova А. Antonov L. Bogdanov N. Tsvetkov |
| author_facet | Vanya Slavcheva T. Lukanov G. Balatsenko S. Angelova А. Antonov L. Bogdanov N. Tsvetkov |
| author_sort | Vanya Slavcheva |
| collection | DOAJ |
| description | Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter’s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically. |
| first_indexed | 2024-04-10T17:52:51Z |
| format | Article |
| id | doaj.art-525b85a2161340d08f39679002df6bb8 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T17:52:51Z |
| publishDate | 2010-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-525b85a2161340d08f39679002df6bb82023-02-02T19:58:43ZengMDPI AGHematology Reports2038-83222038-83302010-12-0121e11e1110.4081/hr.2010.e111345Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndromeVanya Slavcheva0T. LukanovG. BalatsenkoS. AngelovaА. AntonovL. BogdanovN. TsvetkovHematologist-University Hospital PlevenKlinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter’s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.http://www.pagepress.org/journals/index.php/hr/article/view/2190GeneticsKlinefelter`s syndromeLeukemiaRemission |
| spellingShingle | Vanya Slavcheva T. Lukanov G. Balatsenko S. Angelova А. Antonov L. Bogdanov N. Tsvetkov Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome Hematology Reports Genetics Klinefelter`s syndrome Leukemia Remission |
| title | Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome |
| title_full | Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome |
| title_fullStr | Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome |
| title_full_unstemmed | Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome |
| title_short | Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome |
| title_sort | clinical case of acute myeloblastic leukemia with t 8 21 q22 q22 in a patient with klinefelter s syndrome |
| topic | Genetics Klinefelter`s syndrome Leukemia Remission |
| url | http://www.pagepress.org/journals/index.php/hr/article/view/2190 |
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