HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection
The incidence of oropharyngeal cancer (OPC) related to infection with human papillomavirus (HPV) is rising, making it now the most common HPV-related malignancy in the United States. These tumors present differently than traditional mucosal head and neck cancers, and those affected often lack classi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-08-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2019.1600985 |
| _version_ | 1827767363047522304 |
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| author | Mary Roz Timbang Michael W. Sim Arnaud F. Bewley D. Gregory Farwell Avinash Mantravadi Michael G. Moore |
| author_facet | Mary Roz Timbang Michael W. Sim Arnaud F. Bewley D. Gregory Farwell Avinash Mantravadi Michael G. Moore |
| author_sort | Mary Roz Timbang |
| collection | DOAJ |
| description | The incidence of oropharyngeal cancer (OPC) related to infection with human papillomavirus (HPV) is rising, making it now the most common HPV-related malignancy in the United States. These tumors present differently than traditional mucosal head and neck cancers, and those affected often lack classic risk factors such as tobacco and alcohol use. Currently, there are no approved approaches for prevention and early detection of disease, thus leading many patients to present with advanced cancers requiring intense surgical or nonsurgical therapies resulting in significant side effects and cost to the health-care system. In this review, we outline the evolving epidemiology of HPV-related OPC. We also summarize the available evidence corresponding to HPV-related OPC prevention, including efficacy and safety of the HPV vaccine in preventing oral HPV infections. Finally, we describe emerging techniques for identifying and screening those who may be at high risk for developing these tumors. |
| first_indexed | 2024-03-11T11:57:42Z |
| format | Article |
| id | doaj.art-525c207cfb844dabb49d1c68418730f7 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T11:57:42Z |
| publishDate | 2019-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-525c207cfb844dabb49d1c68418730f72023-11-08T11:55:19ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2019-08-01157-81920192810.1080/21645515.2019.16009851600985HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detectionMary Roz Timbang0Michael W. Sim1Arnaud F. Bewley2D. Gregory Farwell3Avinash Mantravadi4Michael G. Moore5The University of California, DavisIndiana UniversityThe University of California, DavisThe University of California, DavisIndiana UniversityIndiana UniversityThe incidence of oropharyngeal cancer (OPC) related to infection with human papillomavirus (HPV) is rising, making it now the most common HPV-related malignancy in the United States. These tumors present differently than traditional mucosal head and neck cancers, and those affected often lack classic risk factors such as tobacco and alcohol use. Currently, there are no approved approaches for prevention and early detection of disease, thus leading many patients to present with advanced cancers requiring intense surgical or nonsurgical therapies resulting in significant side effects and cost to the health-care system. In this review, we outline the evolving epidemiology of HPV-related OPC. We also summarize the available evidence corresponding to HPV-related OPC prevention, including efficacy and safety of the HPV vaccine in preventing oral HPV infections. Finally, we describe emerging techniques for identifying and screening those who may be at high risk for developing these tumors.http://dx.doi.org/10.1080/21645515.2019.1600985oropharyngeal cancerhpvvaccinationdetectionscreeningprevention |
| spellingShingle | Mary Roz Timbang Michael W. Sim Arnaud F. Bewley D. Gregory Farwell Avinash Mantravadi Michael G. Moore HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection Human Vaccines & Immunotherapeutics oropharyngeal cancer hpv vaccination detection screening prevention |
| title | HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection |
| title_full | HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection |
| title_fullStr | HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection |
| title_full_unstemmed | HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection |
| title_short | HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection |
| title_sort | hpv related oropharyngeal cancer a review on burden of the disease and opportunities for prevention and early detection |
| topic | oropharyngeal cancer hpv vaccination detection screening prevention |
| url | http://dx.doi.org/10.1080/21645515.2019.1600985 |
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