Genital Micro-Organisms in Pregnancy
The microbiome of the female genital tract may undergo changes in pregnancy due to metabolic, endocrinological, and immunological alterations. These dysbiotic states may cause infections which may ascend upwards to the feto-placental unit or may be seeded hematogenously. These low grade and often lo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpubh.2020.00225/full |
| _version_ | 1818205150496423936 |
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| author | Rashmi Bagga Parul Arora |
| author_facet | Rashmi Bagga Parul Arora |
| author_sort | Rashmi Bagga |
| collection | DOAJ |
| description | The microbiome of the female genital tract may undergo changes in pregnancy due to metabolic, endocrinological, and immunological alterations. These dysbiotic states may cause infections which may ascend upwards to the feto-placental unit or may be seeded hematogenously. These low grade and often low virulent infectious states lead to chronic inflammatory states and maybe associated with adverse maternal and neonatal outcome. Organisms have been isolated from amniotic fluid and placentae from women delivering pre-term; however the possibility of contamination cannot be conclusively ruled out. Common vaginal dysbiotic states often cause symptoms that are overlooked and often untreated. Vulvovaginal Candidiasis (VVC), Bacterial Vaginosis (BV), and Trichomonas Vaginitis (TV) are the commonly occurring dysbiotic states leading to vaginal infective states in pregnancy. With the advent of novel technologies like Next Generation sequencing (NGS), it will soon be possible to comprehensively map the vaginal microbiome and assess the interplay of each microbial state with their effects in pregnancy. This may open new avenues for antibiotic recommendations, probiotics and potential alternate therapies for dysbiotic states leading to pregnancy complications. |
| first_indexed | 2024-12-12T03:52:33Z |
| format | Article |
| id | doaj.art-525c4c6360954d808b6b2d77f442ba2d |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-12T03:52:33Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-525c4c6360954d808b6b2d77f442ba2d2022-12-22T00:39:20ZengFrontiers Media S.A.Frontiers in Public Health2296-25652020-06-01810.3389/fpubh.2020.00225533639Genital Micro-Organisms in PregnancyRashmi Bagga0Parul Arora1Department of Obstetrics & Gynaecology, Post Graduate Institute of Medical Education & Research, Chandigarh, IndiaReproductive Medicine, Nova IVF Fertility, Ahmedabad, IndiaThe microbiome of the female genital tract may undergo changes in pregnancy due to metabolic, endocrinological, and immunological alterations. These dysbiotic states may cause infections which may ascend upwards to the feto-placental unit or may be seeded hematogenously. These low grade and often low virulent infectious states lead to chronic inflammatory states and maybe associated with adverse maternal and neonatal outcome. Organisms have been isolated from amniotic fluid and placentae from women delivering pre-term; however the possibility of contamination cannot be conclusively ruled out. Common vaginal dysbiotic states often cause symptoms that are overlooked and often untreated. Vulvovaginal Candidiasis (VVC), Bacterial Vaginosis (BV), and Trichomonas Vaginitis (TV) are the commonly occurring dysbiotic states leading to vaginal infective states in pregnancy. With the advent of novel technologies like Next Generation sequencing (NGS), it will soon be possible to comprehensively map the vaginal microbiome and assess the interplay of each microbial state with their effects in pregnancy. This may open new avenues for antibiotic recommendations, probiotics and potential alternate therapies for dysbiotic states leading to pregnancy complications.https://www.frontiersin.org/article/10.3389/fpubh.2020.00225/fullgenital microbiomedysbiosisbacterial vaginosiscandidiasisTrichomonas vaginalis |
| spellingShingle | Rashmi Bagga Parul Arora Genital Micro-Organisms in Pregnancy Frontiers in Public Health genital microbiome dysbiosis bacterial vaginosis candidiasis Trichomonas vaginalis |
| title | Genital Micro-Organisms in Pregnancy |
| title_full | Genital Micro-Organisms in Pregnancy |
| title_fullStr | Genital Micro-Organisms in Pregnancy |
| title_full_unstemmed | Genital Micro-Organisms in Pregnancy |
| title_short | Genital Micro-Organisms in Pregnancy |
| title_sort | genital micro organisms in pregnancy |
| topic | genital microbiome dysbiosis bacterial vaginosis candidiasis Trichomonas vaginalis |
| url | https://www.frontiersin.org/article/10.3389/fpubh.2020.00225/full |
| work_keys_str_mv | AT rashmibagga genitalmicroorganismsinpregnancy AT parularora genitalmicroorganismsinpregnancy |