<i>Lactobacillus ruminis</i> Alleviates DSS-Induced Colitis by Inflammatory Cytokines and Gut Microbiota Modulation
<i>Lactobacillus ruminis</i> can stimulate the immune response in vitro, but previous studies were only carried out in vitro and the anti-inflammatory effects of <i>L. ruminis</i> needs more in vivo evidences. In this study, the immune regulation and potential mechanisms of &...
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MDPI AG
2021-06-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/6/1349 |
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| author | Bo Yang Mingjie Li Shuo Wang R. Paul Ross Catherine Stanton Jianxin Zhao Hao Zhang Wei Chen |
| author_facet | Bo Yang Mingjie Li Shuo Wang R. Paul Ross Catherine Stanton Jianxin Zhao Hao Zhang Wei Chen |
| author_sort | Bo Yang |
| collection | DOAJ |
| description | <i>Lactobacillus ruminis</i> can stimulate the immune response in vitro, but previous studies were only carried out in vitro and the anti-inflammatory effects of <i>L. ruminis</i> needs more in vivo evidences. In this study, the immune regulation and potential mechanisms of <i>L. ruminis</i> was investigated in DSS-induced colitis mice. <i>L. ruminis</i> FXJWS27L3 and <i>L. ruminis</i> FXJSW17L1 relieved the symptoms of colitis, including inhibition of colon shortening and colon tissue damage. <i>L. ruminis</i> FXJWS27L3 significantly reduced the pro-inflammatory cytokines IL-1β, TNF-α, and IL-17, while <i>L. ruminis</i> FXJSW17L1 significantly increased short chain fatty acids in mice feces. Moreover, <i>L. ruminis</i> FXJWS27L3 and <i>L. ruminis</i> FXJSW17L1 treatments significantly increased the gut microbiota diversity and balance the intestine microbiota profiles, which improved the imbalance of intestine microbiota composition to a certain extent. The results showed that <i>L. ruminis</i> can alleviate DSS-induced colitis, which possibly was related to promoting the expression of pro-inflammatory cytokines, up-regulating SCFAs and restoring the imbalance of gut microbiota. |
| first_indexed | 2024-03-10T10:30:12Z |
| format | Article |
| id | doaj.art-525cdc237bf74bd2b7b3f97e6dca4c23 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T10:30:12Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-525cdc237bf74bd2b7b3f97e6dca4c232023-11-21T23:42:08ZengMDPI AGFoods2304-81582021-06-01106134910.3390/foods10061349<i>Lactobacillus ruminis</i> Alleviates DSS-Induced Colitis by Inflammatory Cytokines and Gut Microbiota ModulationBo Yang0Mingjie Li1Shuo Wang2R. Paul Ross3Catherine Stanton4Jianxin Zhao5Hao Zhang6Wei Chen7State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaInternational Joint Research Laboratory for Pharmabiotics & Antibiotic Resistance, Jiangnan University, Wuxi 214122, ChinaInternational Joint Research Laboratory for Pharmabiotics & Antibiotic Resistance, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China<i>Lactobacillus ruminis</i> can stimulate the immune response in vitro, but previous studies were only carried out in vitro and the anti-inflammatory effects of <i>L. ruminis</i> needs more in vivo evidences. In this study, the immune regulation and potential mechanisms of <i>L. ruminis</i> was investigated in DSS-induced colitis mice. <i>L. ruminis</i> FXJWS27L3 and <i>L. ruminis</i> FXJSW17L1 relieved the symptoms of colitis, including inhibition of colon shortening and colon tissue damage. <i>L. ruminis</i> FXJWS27L3 significantly reduced the pro-inflammatory cytokines IL-1β, TNF-α, and IL-17, while <i>L. ruminis</i> FXJSW17L1 significantly increased short chain fatty acids in mice feces. Moreover, <i>L. ruminis</i> FXJWS27L3 and <i>L. ruminis</i> FXJSW17L1 treatments significantly increased the gut microbiota diversity and balance the intestine microbiota profiles, which improved the imbalance of intestine microbiota composition to a certain extent. The results showed that <i>L. ruminis</i> can alleviate DSS-induced colitis, which possibly was related to promoting the expression of pro-inflammatory cytokines, up-regulating SCFAs and restoring the imbalance of gut microbiota.https://www.mdpi.com/2304-8158/10/6/1349<i>Lactobacillus ruminis</i>DSS-induced colitisinflammatory cytokinesSCFAsgut microbiota |
| spellingShingle | Bo Yang Mingjie Li Shuo Wang R. Paul Ross Catherine Stanton Jianxin Zhao Hao Zhang Wei Chen <i>Lactobacillus ruminis</i> Alleviates DSS-Induced Colitis by Inflammatory Cytokines and Gut Microbiota Modulation Foods <i>Lactobacillus ruminis</i> DSS-induced colitis inflammatory cytokines SCFAs gut microbiota |
| title | <i>Lactobacillus ruminis</i> Alleviates DSS-Induced Colitis by Inflammatory Cytokines and Gut Microbiota Modulation |
| title_full | <i>Lactobacillus ruminis</i> Alleviates DSS-Induced Colitis by Inflammatory Cytokines and Gut Microbiota Modulation |
| title_fullStr | <i>Lactobacillus ruminis</i> Alleviates DSS-Induced Colitis by Inflammatory Cytokines and Gut Microbiota Modulation |
| title_full_unstemmed | <i>Lactobacillus ruminis</i> Alleviates DSS-Induced Colitis by Inflammatory Cytokines and Gut Microbiota Modulation |
| title_short | <i>Lactobacillus ruminis</i> Alleviates DSS-Induced Colitis by Inflammatory Cytokines and Gut Microbiota Modulation |
| title_sort | i lactobacillus ruminis i alleviates dss induced colitis by inflammatory cytokines and gut microbiota modulation |
| topic | <i>Lactobacillus ruminis</i> DSS-induced colitis inflammatory cytokines SCFAs gut microbiota |
| url | https://www.mdpi.com/2304-8158/10/6/1349 |
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