Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations
A carboxymethyl derivative of scleroglucan (Scl-CM) with a 65±5% carboxylic group degree of derivatization (DD) was recently synthesized and characterized. Aqueous solutions of the polymer underwent to a sharp transition toward a gel like behaviour in the presence of divalent ions such as Ca+2. Phys...
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/14/8/2684/ |
| _version_ | 1818750104480251904 |
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| author | Maria Antonietta Casadei Federica Vitali Beatrice Tita Pietro Matricardi Patrizia Paolicelli Federica Corrente |
| author_facet | Maria Antonietta Casadei Federica Vitali Beatrice Tita Pietro Matricardi Patrizia Paolicelli Federica Corrente |
| author_sort | Maria Antonietta Casadei |
| collection | DOAJ |
| description | A carboxymethyl derivative of scleroglucan (Scl-CM) with a 65±5% carboxylic group degree of derivatization (DD) was recently synthesized and characterized. Aqueous solutions of the polymer underwent to a sharp transition toward a gel like behaviour in the presence of divalent ions such as Ca+2. Physical hydrogels with different Scl-CM/Ca+2 ratios were prepared and characterized for their rheological behaviour. Their potential as drug delivery systems was also evaluated. To this end three non steroidal anti-inflammatory drugs (NSAIDs) were loaded into the hydrogels obtained with 2% w/v solution of Scl-CM and 0.05 and 0.1 M CaCl2. The release rate of the drugs was critically related to the salt concentration. By an appropriate combination of the hydrogels prepared using different amounts of salt, it was possible to obtain a system able to release diclofenac with zero-order kinetics. Primary skin irritation tests showed a good biocompatibility of the new polymer, as well as of its hydrogels. These results suggest a potential of the new hydrogels for the development of modified delivery systems in topical formulations. |
| first_indexed | 2024-12-18T04:14:22Z |
| format | Article |
| id | doaj.art-525ce8c3749d475e8ba24307ca9df564 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T04:14:22Z |
| publishDate | 2009-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-525ce8c3749d475e8ba24307ca9df5642022-12-21T21:21:23ZengMDPI AGMolecules1420-30492009-07-011482684269810.3390/molecules14082684Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical FormulationsMaria Antonietta CasadeiFederica VitaliBeatrice TitaPietro MatricardiPatrizia PaolicelliFederica CorrenteA carboxymethyl derivative of scleroglucan (Scl-CM) with a 65±5% carboxylic group degree of derivatization (DD) was recently synthesized and characterized. Aqueous solutions of the polymer underwent to a sharp transition toward a gel like behaviour in the presence of divalent ions such as Ca+2. Physical hydrogels with different Scl-CM/Ca+2 ratios were prepared and characterized for their rheological behaviour. Their potential as drug delivery systems was also evaluated. To this end three non steroidal anti-inflammatory drugs (NSAIDs) were loaded into the hydrogels obtained with 2% w/v solution of Scl-CM and 0.05 and 0.1 M CaCl2. The release rate of the drugs was critically related to the salt concentration. By an appropriate combination of the hydrogels prepared using different amounts of salt, it was possible to obtain a system able to release diclofenac with zero-order kinetics. Primary skin irritation tests showed a good biocompatibility of the new polymer, as well as of its hydrogels. These results suggest a potential of the new hydrogels for the development of modified delivery systems in topical formulations.http://www.mdpi.com/1420-3049/14/8/2684/carboxymethyl scleroglucanphysical hydrogelscontrolled releaserheologymucoadhesivenessprimary skin irritation |
| spellingShingle | Maria Antonietta Casadei Federica Vitali Beatrice Tita Pietro Matricardi Patrizia Paolicelli Federica Corrente Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations Molecules carboxymethyl scleroglucan physical hydrogels controlled release rheology mucoadhesiveness primary skin irritation |
| title | Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations |
| title_full | Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations |
| title_fullStr | Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations |
| title_full_unstemmed | Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations |
| title_short | Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations |
| title_sort | physical carboxymethylscleroglucan calcium ion hydrogels as modified drug delivery systems in topical formulations |
| topic | carboxymethyl scleroglucan physical hydrogels controlled release rheology mucoadhesiveness primary skin irritation |
| url | http://www.mdpi.com/1420-3049/14/8/2684/ |
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