Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations

Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations

A carboxymethyl derivative of scleroglucan (Scl-CM) with a 65±5% carboxylic group degree of derivatization (DD) was recently synthesized and characterized. Aqueous solutions of the polymer underwent to a sharp transition toward a gel like behaviour in the presence of divalent ions such as Ca+2. Phys...

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Bibliographic Details
Main Authors: Maria Antonietta Casadei, Federica Vitali, Beatrice Tita, Pietro Matricardi, Patrizia Paolicelli, Federica Corrente
Format: Article
Language:English
Published: MDPI AG 2009-07-01
Series:Molecules
Subjects:
carboxymethyl scleroglucan
physical hydrogels
controlled release
rheology
mucoadhesiveness
primary skin irritation
Online Access:http://www.mdpi.com/1420-3049/14/8/2684/

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