Host Cell Neddylation Facilitates Alphaherpesvirus Entry in a Virus-Specific and Cell-Dependent Manner

Host Cell Neddylation Facilitates Alphaherpesvirus Entry in a Virus-Specific and Cell-Dependent Manner

ABSTRACT Herpes simplex virus 1 (HSV-1) commandeers the host cell proteasome at several steps of its replication cycle, including entry. Here we demonstrate that HSV-2, pseudorabies virus (PRV), and bovine herpesvirus 1 (BoHV-1) entry are blocked by bortezomib, a proteasome inhibitor that is an FDA-...

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Bibliographic Details
Main Authors: Becky H. Lee, Giulia Tebaldi, Suzanne M. Pritchard, Anthony V. Nicola
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
bovine herpesvirus 1
endocytosis
herpes simplex virus
herpesviruses
neddylation
proteasome
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03114-22

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