Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology
The authors attempt to address the importance of timely detection and management of cervical intraepithelial neoplasia (CIN) to prevent cervical cancer. The study focused on the potential of electrical impedance spectroscopy (EIS) as an adjunct to colposcopy, aiming to enhance the accuracy of identi...
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MDPI AG
2023-10-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/11/2139 |
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| author | Georgios Panagakis Ioannis K. Papapanagiotou Charalampos Theofanakis Paraskevi Tsetsa Adamantia Kontogeorgi Nikolaos Thomakos Alexandros Rodolakis Dimitrios Haidopoulos |
| author_facet | Georgios Panagakis Ioannis K. Papapanagiotou Charalampos Theofanakis Paraskevi Tsetsa Adamantia Kontogeorgi Nikolaos Thomakos Alexandros Rodolakis Dimitrios Haidopoulos |
| author_sort | Georgios Panagakis |
| collection | DOAJ |
| description | The authors attempt to address the importance of timely detection and management of cervical intraepithelial neoplasia (CIN) to prevent cervical cancer. The study focused on the potential of electrical impedance spectroscopy (EIS) as an adjunct to colposcopy, aiming to enhance the accuracy of identifying high-grade cervical lesions. Colposcopy, a widely used technique, exhibited variable sensitivity in detecting high-grade lesions, which relies on the expertise of the operator. The study’s primary objective is to evaluate the effectiveness of combining colposcopy with EIS in detecting high-grade cervical lesions among patients initially diagnosed with low-grade CIN based on cytology. We employed a cross-sectional observational design, recruiting 101 women with abnormal cervical cytology results. The participants underwent colposcopy with acetic acid and subsequent EIS using the ZedScan device. The ZedScan results are categorized into color-coded probability levels, with red indicating the highest likelihood of high-grade squamous intraepithelial lesions (HSIL) occurrence. Results revealed that ZedScan exhibits a sensitivity rate of 89.5% and a specificity rate of 84% for detecting high-grade lesions. Colposcopy, on the other hand, recorded a sensitivity rate of 85.5% and a specificity rate of 92%. The agreement rate between ZedScan and biopsy is 79.2%, as indicated by a kappa coefficient of 0.71, while the agreement rate between colposcopy and biopsy is 74.3%, with a kappa coefficient of 0.71. |
| first_indexed | 2024-03-09T16:40:01Z |
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| id | doaj.art-525ddea92362453fa3160e8c4d6da090 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T16:40:01Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-525ddea92362453fa3160e8c4d6da0902023-11-24T14:52:19ZengMDPI AGLife2075-17292023-10-011311213910.3390/life13112139Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in CytologyGeorgios Panagakis0Ioannis K. Papapanagiotou1Charalampos Theofanakis2Paraskevi Tsetsa3Adamantia Kontogeorgi4Nikolaos Thomakos5Alexandros Rodolakis6Dimitrios Haidopoulos7Department of Obstetrics and Gynecology, Alexandra General Hospital, University of Athens, 4-2 Lourou, 115 28 Athens, GreeceDepartment of Obstetrics and Gynecology, Alexandra General Hospital, University of Athens, 4-2 Lourou, 115 28 Athens, GreeceDepartment of Obstetrics and Gynecology, Alexandra General Hospital, University of Athens, 4-2 Lourou, 115 28 Athens, GreeceDepartment of Obstetrics and Gynecology, Alexandra General Hospital, University of Athens, 4-2 Lourou, 115 28 Athens, GreeceDepartment of Obstetrics and Gynecology, Attikon General Hospital, University of Athens, Rimini 1, 124 62 Haidari, GreeceDepartment of Obstetrics and Gynecology, Alexandra General Hospital, University of Athens, 4-2 Lourou, 115 28 Athens, GreeceDepartment of Obstetrics and Gynecology, Alexandra General Hospital, University of Athens, 4-2 Lourou, 115 28 Athens, GreeceDepartment of Obstetrics and Gynecology, Alexandra General Hospital, University of Athens, 4-2 Lourou, 115 28 Athens, GreeceThe authors attempt to address the importance of timely detection and management of cervical intraepithelial neoplasia (CIN) to prevent cervical cancer. The study focused on the potential of electrical impedance spectroscopy (EIS) as an adjunct to colposcopy, aiming to enhance the accuracy of identifying high-grade cervical lesions. Colposcopy, a widely used technique, exhibited variable sensitivity in detecting high-grade lesions, which relies on the expertise of the operator. The study’s primary objective is to evaluate the effectiveness of combining colposcopy with EIS in detecting high-grade cervical lesions among patients initially diagnosed with low-grade CIN based on cytology. We employed a cross-sectional observational design, recruiting 101 women with abnormal cervical cytology results. The participants underwent colposcopy with acetic acid and subsequent EIS using the ZedScan device. The ZedScan results are categorized into color-coded probability levels, with red indicating the highest likelihood of high-grade squamous intraepithelial lesions (HSIL) occurrence. Results revealed that ZedScan exhibits a sensitivity rate of 89.5% and a specificity rate of 84% for detecting high-grade lesions. Colposcopy, on the other hand, recorded a sensitivity rate of 85.5% and a specificity rate of 92%. The agreement rate between ZedScan and biopsy is 79.2%, as indicated by a kappa coefficient of 0.71, while the agreement rate between colposcopy and biopsy is 74.3%, with a kappa coefficient of 0.71.https://www.mdpi.com/2075-1729/13/11/2139cervical intraepithelial neoplasiacolposcopyelectrical impedance spectroscropyhigh-grade CIN zedscan devicelow-grade CIN |
| spellingShingle | Georgios Panagakis Ioannis K. Papapanagiotou Charalampos Theofanakis Paraskevi Tsetsa Adamantia Kontogeorgi Nikolaos Thomakos Alexandros Rodolakis Dimitrios Haidopoulos Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology Life cervical intraepithelial neoplasia colposcopy electrical impedance spectroscropy high-grade CIN zedscan device low-grade CIN |
| title | Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology |
| title_full | Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology |
| title_fullStr | Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology |
| title_full_unstemmed | Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology |
| title_short | Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology |
| title_sort | detection of high grade cervical intraepithelial neoplasia by electrical impedance spectroscopy in women diagnosed with low grade cervical intraepithelial neoplasia in cytology |
| topic | cervical intraepithelial neoplasia colposcopy electrical impedance spectroscropy high-grade CIN zedscan device low-grade CIN |
| url | https://www.mdpi.com/2075-1729/13/11/2139 |
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