New therapies for the treatment of heart failure: a summary of recent accomplishments
Filip Machaj,1 Elzbieta Dembowska,2 Jakub Rosik,1 Bartosz Szostak,1 Małgorzata Mazurek-Mochol,2 Andrzej Pawlik1 1Department of Physiology, Pomeranian Medical University, Szczecin, Poland; 2Department of Periodontology, Pomeranian Medical University, Szczecin, Poland Abstract: Despite continuous ef...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2019-01-01
|
| Series: | Therapeutics and Clinical Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/new-therapies-for-the-treatment-of-heart-failure-a-summary-of-recent-a-peer-reviewed-article-TCRM |
| _version_ | 1818696199040925696 |
|---|---|
| author | Machaj F Dembowska E Rosik J Szostak B Mazurek-Mochol M Pawlik A |
| author_facet | Machaj F Dembowska E Rosik J Szostak B Mazurek-Mochol M Pawlik A |
| author_sort | Machaj F |
| collection | DOAJ |
| description | Filip Machaj,1 Elzbieta Dembowska,2 Jakub Rosik,1 Bartosz Szostak,1 Małgorzata Mazurek-Mochol,2 Andrzej Pawlik1 1Department of Physiology, Pomeranian Medical University, Szczecin, Poland; 2Department of Periodontology, Pomeranian Medical University, Szczecin, Poland Abstract: Despite continuous efforts to prevent cardiovascular diseases (CVDs), heart failure prevails as the number one cause of death in developed countries. To properly treat CVDs, scientists had to take a closer look at the factors that contribute to their pathogenesis and either modernize current pharmaceuticals or develop brand new treatments. Enhancement of current drugs, such as tolvaptan and omecamtiv mecarbil, sheds new light on already-known therapies. Tolvaptan, a vasopressin antagonist, could be adopted in heart failure therapy as it reduces pre- and afterload by decreasing systolic blood pressure and blood volume. Omecamtiv mecarbil, which is a myosin binding peptide, could aid cardiac contractility. The next generation vasodilators, serelaxin and ularitide, are based on naturally occurring peptides and they reduce peripheral vascular resistance and increase the cardiac index. In combination with their anti-inflammatory properties, they could turn out to be extremely potent drugs for heart failure treatment. Cardiotrophin has exceeded many researchers’ expectations, as evidence suggests that it could cause sarcomere hypertrophy without excessive proliferation of connective tissue. Rapid progress in gene therapy has caused it to finally be considered as one of the viable options for the treatment of CVDs. This novel therapeutic approach could restore stable heart function either by restoring depleted membrane proteins or by balancing the intracellular calcium concentration. Although it has been set back by problems concerning its long-term effects, it is still highly likely to succeed. Keywords: heart failure, therapy, cardiovascular diseases
|
| first_indexed | 2024-12-17T13:57:34Z |
| format | Article |
| id | doaj.art-525e476508154dc1bfe6b73a5bc6a73e |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-17T13:57:34Z |
| publishDate | 2019-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-525e476508154dc1bfe6b73a5bc6a73e2022-12-21T21:45:52ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2019-01-01Volume 1514715543704New therapies for the treatment of heart failure: a summary of recent accomplishmentsMachaj FDembowska ERosik JSzostak BMazurek-Mochol MPawlik AFilip Machaj,1 Elzbieta Dembowska,2 Jakub Rosik,1 Bartosz Szostak,1 Małgorzata Mazurek-Mochol,2 Andrzej Pawlik1 1Department of Physiology, Pomeranian Medical University, Szczecin, Poland; 2Department of Periodontology, Pomeranian Medical University, Szczecin, Poland Abstract: Despite continuous efforts to prevent cardiovascular diseases (CVDs), heart failure prevails as the number one cause of death in developed countries. To properly treat CVDs, scientists had to take a closer look at the factors that contribute to their pathogenesis and either modernize current pharmaceuticals or develop brand new treatments. Enhancement of current drugs, such as tolvaptan and omecamtiv mecarbil, sheds new light on already-known therapies. Tolvaptan, a vasopressin antagonist, could be adopted in heart failure therapy as it reduces pre- and afterload by decreasing systolic blood pressure and blood volume. Omecamtiv mecarbil, which is a myosin binding peptide, could aid cardiac contractility. The next generation vasodilators, serelaxin and ularitide, are based on naturally occurring peptides and they reduce peripheral vascular resistance and increase the cardiac index. In combination with their anti-inflammatory properties, they could turn out to be extremely potent drugs for heart failure treatment. Cardiotrophin has exceeded many researchers’ expectations, as evidence suggests that it could cause sarcomere hypertrophy without excessive proliferation of connective tissue. Rapid progress in gene therapy has caused it to finally be considered as one of the viable options for the treatment of CVDs. This novel therapeutic approach could restore stable heart function either by restoring depleted membrane proteins or by balancing the intracellular calcium concentration. Although it has been set back by problems concerning its long-term effects, it is still highly likely to succeed. Keywords: heart failure, therapy, cardiovascular diseases https://www.dovepress.com/new-therapies-for-the-treatment-of-heart-failure-a-summary-of-recent-a-peer-reviewed-article-TCRMheart failuretherapycardiovascular diseases |
| spellingShingle | Machaj F Dembowska E Rosik J Szostak B Mazurek-Mochol M Pawlik A New therapies for the treatment of heart failure: a summary of recent accomplishments Therapeutics and Clinical Risk Management heart failure therapy cardiovascular diseases |
| title | New therapies for the treatment of heart failure: a summary of recent accomplishments |
| title_full | New therapies for the treatment of heart failure: a summary of recent accomplishments |
| title_fullStr | New therapies for the treatment of heart failure: a summary of recent accomplishments |
| title_full_unstemmed | New therapies for the treatment of heart failure: a summary of recent accomplishments |
| title_short | New therapies for the treatment of heart failure: a summary of recent accomplishments |
| title_sort | new therapies for the treatment of heart failure a summary of recent accomplishments |
| topic | heart failure therapy cardiovascular diseases |
| url | https://www.dovepress.com/new-therapies-for-the-treatment-of-heart-failure-a-summary-of-recent-a-peer-reviewed-article-TCRM |
| work_keys_str_mv | AT machajf newtherapiesforthetreatmentofheartfailureasummaryofrecentaccomplishments AT dembowskae newtherapiesforthetreatmentofheartfailureasummaryofrecentaccomplishments AT rosikj newtherapiesforthetreatmentofheartfailureasummaryofrecentaccomplishments AT szostakb newtherapiesforthetreatmentofheartfailureasummaryofrecentaccomplishments AT mazurekmocholm newtherapiesforthetreatmentofheartfailureasummaryofrecentaccomplishments AT pawlika newtherapiesforthetreatmentofheartfailureasummaryofrecentaccomplishments |