Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial Carcinoma
Minimally invasive surgery may not be an appropriate surgical approach in intermediate- and high-risk endometrial carcinoma, even though adjuvant therapy is given. The objective of this study was to evaluate the results of open surgery including lymphadenectomy without adjuvant therapy in patients w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/5/298 |
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| author | Isao Otsuka Takuto Matsuura Takahiro Mitani Koji Otsuka Yoshihisa Kanamoto |
| author_facet | Isao Otsuka Takuto Matsuura Takahiro Mitani Koji Otsuka Yoshihisa Kanamoto |
| author_sort | Isao Otsuka |
| collection | DOAJ |
| description | Minimally invasive surgery may not be an appropriate surgical approach in intermediate- and high-risk endometrial carcinoma, even though adjuvant therapy is given. The objective of this study was to evaluate the results of open surgery including lymphadenectomy without adjuvant therapy in patients with uterine-confined intermediate- and high-risk endometrioid endometrial carcinoma. Two hundred fifty-six patients with uterine-confined endometrioid endometrial carcinoma were treated with open surgery, including pelvic with or without para-aortic lymphadenectomy. Of the 81 patients with uterine-confined intermediate- or high-risk disease, 77 were treated with systematic lymphadenectomy without adjuvant therapy. Seven patients developed recurrence, comprising 5.5% (3/55) and 18.2% (4/22) of the intermediate- and high-risk patients, respectively. The time to recurrence was 1–66 months. The sites of recurrence were the vaginal apex (<i>n</i> = 2), lung (<i>n</i> = 2), vaginal sidewall (<i>n</i> = 1), pelvic lymph nodes (<i>n</i> = 1), and para-aortic to supraclavicular nodes (<i>n</i> = 1). Of these, five patients were alive without disease after salvage treatment, but two understaged high-risk patients died of disease. The five-year disease-specific survival rates of intermediate- and high-risk patients were 100% and 90%, respectively. The present study indicated that patients with uterine-confined intermediate- and high-risk endometrioid endometrial carcinoma had excellent survival when treated with open surgery, including lymphadenectomy alone. The safety of omitting adjuvant therapy should be evaluated in prospective randomized trials comparing open surgery with minimally invasive surgery. |
| first_indexed | 2024-03-10T03:03:45Z |
| format | Article |
| id | doaj.art-525fee3c116e4385b43dd188bc7c478b |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T03:03:45Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-525fee3c116e4385b43dd188bc7c478b2023-11-23T10:37:31ZengMDPI AGCurrent Oncology1198-00521718-77292022-05-012953728373710.3390/curroncol29050298Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial CarcinomaIsao Otsuka0Takuto Matsuura1Takahiro Mitani2Koji Otsuka3Yoshihisa Kanamoto4Department of Obstetrics and Gynecology, Kameda Medical Center, Kamogawa 296-8602, Chiba, JapanDepartment of Obstetrics and Gynecology, Kameda Medical Center, Kamogawa 296-8602, Chiba, JapanDepartment of Obstetrics and Gynecology, Kameda Medical Center, Kamogawa 296-8602, Chiba, JapanDepartment of Obstetrics and Gynecology, Kameda Medical Center, Kamogawa 296-8602, Chiba, JapanDepartment of Obstetrics and Gynecology, Kameda Medical Center, Kamogawa 296-8602, Chiba, JapanMinimally invasive surgery may not be an appropriate surgical approach in intermediate- and high-risk endometrial carcinoma, even though adjuvant therapy is given. The objective of this study was to evaluate the results of open surgery including lymphadenectomy without adjuvant therapy in patients with uterine-confined intermediate- and high-risk endometrioid endometrial carcinoma. Two hundred fifty-six patients with uterine-confined endometrioid endometrial carcinoma were treated with open surgery, including pelvic with or without para-aortic lymphadenectomy. Of the 81 patients with uterine-confined intermediate- or high-risk disease, 77 were treated with systematic lymphadenectomy without adjuvant therapy. Seven patients developed recurrence, comprising 5.5% (3/55) and 18.2% (4/22) of the intermediate- and high-risk patients, respectively. The time to recurrence was 1–66 months. The sites of recurrence were the vaginal apex (<i>n</i> = 2), lung (<i>n</i> = 2), vaginal sidewall (<i>n</i> = 1), pelvic lymph nodes (<i>n</i> = 1), and para-aortic to supraclavicular nodes (<i>n</i> = 1). Of these, five patients were alive without disease after salvage treatment, but two understaged high-risk patients died of disease. The five-year disease-specific survival rates of intermediate- and high-risk patients were 100% and 90%, respectively. The present study indicated that patients with uterine-confined intermediate- and high-risk endometrioid endometrial carcinoma had excellent survival when treated with open surgery, including lymphadenectomy alone. The safety of omitting adjuvant therapy should be evaluated in prospective randomized trials comparing open surgery with minimally invasive surgery.https://www.mdpi.com/1718-7729/29/5/298endometrioid endometrial carcinomaopen surgerylymphadenectomyintermediate-riskhigh-riskadjuvant therapy |
| spellingShingle | Isao Otsuka Takuto Matsuura Takahiro Mitani Koji Otsuka Yoshihisa Kanamoto Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial Carcinoma Current Oncology endometrioid endometrial carcinoma open surgery lymphadenectomy intermediate-risk high-risk adjuvant therapy |
| title | Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial Carcinoma |
| title_full | Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial Carcinoma |
| title_fullStr | Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial Carcinoma |
| title_full_unstemmed | Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial Carcinoma |
| title_short | Open Surgery including Lymphadenectomy without Adjuvant Therapy for Uterine-Confined Intermediate- and High-Risk Endometrioid Endometrial Carcinoma |
| title_sort | open surgery including lymphadenectomy without adjuvant therapy for uterine confined intermediate and high risk endometrioid endometrial carcinoma |
| topic | endometrioid endometrial carcinoma open surgery lymphadenectomy intermediate-risk high-risk adjuvant therapy |
| url | https://www.mdpi.com/1718-7729/29/5/298 |
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