PCSK9 inhibitor alleviates experimental pulmonary fibrosis-induced pulmonary hypertension via attenuating epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling in vivo and in vitro

PCSK9 inhibitor alleviates experimental pulmonary fibrosis-induced pulmonary hypertension via attenuating epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling in vivo and in vitro

BackgroundThe co-occurrence of pulmonary hypertension (PH) in patients with pulmonary fibrosis (PF) is linked to a more unfavorable prognosis and increased mortality compared to PF cases without PH. Early intervention and comprehensive management are pivotal for improving survival outcomes. Proprote...

書目詳細資料
Main Authors:	Jiancheng Lin, Zetao Pan, Jiayan Sun, Xiaowan Wang, Di Yin, Cunyang Huo, Qiang Guo
格式:	Article
語言:	English
出版:	Frontiers Media S.A. 2024-12-01
叢編:	Frontiers in Medicine
主題:	pulmonary fibrosis pulmonary hypertension PCSK9 EMT Wnt β-catenin
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fmed.2024.1509168/full

相似書籍

Increased serum albumin corrected anion gap levels are associated with poor prognosis in septic patients with liver cirrhosis
由: Zetao Pan, et al.
出版: (2024-09-01)

Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/β-catenin pathway
由: Qian Lei, et al.
出版: (2022-09-01)

PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
由: Ding-Qiang Chen, et al.
出版: (2024-07-01)

Knockdown of YAP inhibits growth in Hep-2 laryngeal cancer cells via epithelial-mesenchymal transition and the Wnt/β-catenin pathway
由: Xiaomin Tang, et al.
出版: (2019-07-01)

FERMT3 mediates cigarette smoke-induced epithelial–mesenchymal transition through Wnt/β-catenin signaling
由: Xiaoshan Su, et al.
出版: (2021-11-01)

Alveolar type 2 cells marker gene SFTPC inhibits epithelial-to-mesenchymal transition by upregulating SOX7 and suppressing WNT/β-catenin pathway in non-small cell lung cancer
由: Qiongyin Zhang, et al.
出版: (2024-09-01)

SOX9 drives the epithelial–mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway
由: Jing-Qiang Huang, et al.
出版: (2019-05-01)

The Intra-observer Variability of Volumetric Measurement of Pulmonary Nodules:  Comparison of Two-dimensional and Three-dimensional Method
由: XiaoWan GUO, et al.
出版: (2014-04-01)

Niclosamide - encapsulated lipid nanoparticles for the reversal of pulmonary fibrosis
由: Yan Yu, et al.
出版: (2024-04-01)

β-catenin mediates monocrotaline-induced pulmonary hypertension via glycolysis in rats
由: Hui Meng, et al.
出版: (2024-07-01)

Delta-catenin attenuates medulloblastoma cell invasion by targeting EMT pathway
由: Yuanjun Hu, et al.
出版: (2022-10-01)

TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer
由: Qiang Tang, et al.
出版: (2020-11-01)

MicroRNA-197 Promotes Metastasis of Hepatocellular Carcinoma by Activating Wnt/β-Catenin Signaling
由: Zhaoxia Hu, et al.
出版: (2018-11-01)

A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway
由: Yangyang Tian, et al.
出版: (2023-01-01)

PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction
由: Simon Rauterberg, et al.
出版: (2025-01-01)

Citrus alkaline extracts improve LPS-induced pulmonary fibrosis via epithelial mesenchymal transition signals
由: Li Junjie, et al.
出版: (2023-05-01)

miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt–β-catenin pathway
由: Qiang Liu, et al.
出版: (2019-08-01)

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways
由: Jingkun Zhao, et al.
出版: (2017-03-01)

TRIM29 facilitates the epithelial-to-mesenchymal transition and the progression of colorectal cancer via the activation of the Wnt/β-catenin signaling pathway
由: Juntao Sun, et al.
出版: (2019-02-01)

RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer
由: Qingyuan Li, et al.
出版: (2019-08-01)

Development of non-destructive technique for metallographic studies
由: Yu, Cunyang.
出版: (2011)

Electronic band structure of Ge1-xSnx alloys
由: Yu, Cunyang
出版: (2018)

Lysophosphatidylcholine acyltransferase 1 promotes epithelial-mesenchymal transition of hepatocellular carcinoma via the Wnt/β-catenin signaling pathway
由: Ling Shen, et al.
出版: (2022-05-01)

lncRNA SNHG10 Promotes the Proliferation and Invasion of Osteosarcoma via Wnt/β-Catenin Signaling
由: Shutao Zhu, et al.
出版: (2020-12-01)

Deep learning predicts malignancy and metastasis of solid pulmonary nodules from CT scans
由: Junhao Mu, et al.
出版: (2023-05-01)

Efficacy of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension patients with pulmonary comorbidity
由: Yeqing Wang, et al.
出版: (2024-04-01)

Effect of β-catenin on hypoxia induced epithelial mesenchymal transition in HK-2 cells by regulating Brachyury
由: Ping Sun, et al.
出版: (2025-03-01)

Aerobic exercise training engages the canonical wnt pathway to improve pulmonary function and inflammation in COPD
由: Peijun Li, et al.
出版: (2024-05-01)

PITX2 in pancreatic stellate cells promotes EMT in pancreatic cancer cells via the Wnt/β-catenin pathway
由: Wu Di, et al.
出版: (2023-06-01)

Sex Differences, Estrogen Metabolism and Signaling in the Development of Pulmonary Arterial Hypertension
由: Yanan Sun, et al.
出版: (2021-09-01)

Pulmonary artery intimal sarcoma: a case report and literature review
由: Ding‐Yu Chang, et al.
出版: (2020-03-01)

Multiple cardiac myxofibrosarcomas with complete right pulmonary artery occlusion: a case report
由: Weimin Zhang, et al.
出版: (2023-09-01)

PCSK9: BIOLOGICAL ACTIVITY REGULATION AND CONNECTION WITH LIPID AND CARBOHYDRATE METABOLISM
由: A O Averkova
出版: (2017-09-01)

FOXH1 promotes lung cancer progression by activating the Wnt/β-catenin signaling pathway
由: Jun Zhang, et al.
出版: (2021-06-01)

PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages
由: Lu Wang, et al.
出版: (2022-10-01)

Leptin and PCSK9 concentrations are associated with vascular endothelial cytokines in patients with stable coronary heart disease
由: Wang Qiang, et al.
出版: (2022-01-01)

High CBX8 Expression Leads to Poor Prognosis in Laryngeal Squamous Cell Carcinoma by Inducing EMT by Activating the Wnt/β-Catenin Signaling Pathway
由: Qingchao Meng, et al.
出版: (2022-06-01)

PCSK9 in T-cell function and the immune response
由: Yuying Wang, et al.
出版: (2024-12-01)

AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling
由: Qiang Zhao, et al.
出版: (2021-06-01)

Identifying potential drug targets for idiopathic pulmonary fibrosis: a mendelian randomization study based on the druggable genes
由: Zetao Liu, et al.
出版: (2024-05-01)