PCSK9 inhibitor alleviates experimental pulmonary fibrosis-induced pulmonary hypertension via attenuating epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling in vivo and in vitro

PCSK9 inhibitor alleviates experimental pulmonary fibrosis-induced pulmonary hypertension via attenuating epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling in vivo and in vitro

BackgroundThe co-occurrence of pulmonary hypertension (PH) in patients with pulmonary fibrosis (PF) is linked to a more unfavorable prognosis and increased mortality compared to PF cases without PH. Early intervention and comprehensive management are pivotal for improving survival outcomes. Proprote...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Jiancheng Lin, Zetao Pan, Jiayan Sun, Xiaowan Wang, Di Yin, Cunyang Huo, Qiang Guo
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: Frontiers Media S.A. 2024-12-01
Σειρά:Frontiers in Medicine
Θέματα:
pulmonary fibrosis
pulmonary hypertension
PCSK9
EMT
Wnt
β-catenin
Διαθέσιμο Online:https://www.frontiersin.org/articles/10.3389/fmed.2024.1509168/full

Διαδίκτυο

https://www.frontiersin.org/articles/10.3389/fmed.2024.1509168/full

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