Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment
Abstract This study investigated the long-term visual acuity (VA) outcome in the eyes of children with uveitis and severe visual impairment (SVI; VA ≤ 20/200) at presentation. Fifty-one children [57 eyes; median age, 11 years; 51% female; median follow-up period, 36 months (interquartile range 14.9–...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29159-x |
| _version_ | 1797865043503611904 |
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| author | Usanee Tungsattayathitthan Narisa Rattanalert Wantanee Sittivarakul |
| author_facet | Usanee Tungsattayathitthan Narisa Rattanalert Wantanee Sittivarakul |
| author_sort | Usanee Tungsattayathitthan |
| collection | DOAJ |
| description | Abstract This study investigated the long-term visual acuity (VA) outcome in the eyes of children with uveitis and severe visual impairment (SVI; VA ≤ 20/200) at presentation. Fifty-one children [57 eyes; median age, 11 years; 51% female; median follow-up period, 36 months (interquartile range 14.9–64.4)] aged ≤ 16 years with uveitis managed at our tertiary center from January 2010 to July 2020 were reviewed. Uveitis mainly manifested as unilateral (74.5%), chronic course (82.4%), and panuveitis (43.1%). Ocular toxoplasmosis and toxocariasis were the most common diagnoses (9.8% each). At least one ocular complication at presentation was observed in 93% of the eyes. Overall, the mean logMAR VA improved from 1.8 at presentation to 1.2 at 5 years (P < 0.001). Common causes of poor vision included retinal detachment, atrophic bulbi, and optic atrophy. Predictive factors associated with less VA improvement over the follow-up period included preschool age of uveitis onset (P < 0.001), ocular symptoms duration before uveitis diagnosis ≥ 1 month (P = 0.004), and non-anterior uveitis (P = 0.047). The long-term VA outcome in uveitis-affected eyes with SVI at presentation was unfavorable. Younger age at uveitis onset, delayed presentation, and uveitis involving the posterior segment were associated with poorer VA outcome. |
| first_indexed | 2024-04-09T23:02:46Z |
| format | Article |
| id | doaj.art-5261727c07d443ddaae62468e1a1aadc |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:02:46Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5261727c07d443ddaae62468e1a1aadc2023-03-22T10:53:50ZengNature PortfolioScientific Reports2045-23222023-02-011311910.1038/s41598-023-29159-xLong-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairmentUsanee Tungsattayathitthan0Narisa Rattanalert1Wantanee Sittivarakul2Department of Ophthalmology, Faculty of Medicine, Prince of Songkla UniversityDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla UniversityDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla UniversityAbstract This study investigated the long-term visual acuity (VA) outcome in the eyes of children with uveitis and severe visual impairment (SVI; VA ≤ 20/200) at presentation. Fifty-one children [57 eyes; median age, 11 years; 51% female; median follow-up period, 36 months (interquartile range 14.9–64.4)] aged ≤ 16 years with uveitis managed at our tertiary center from January 2010 to July 2020 were reviewed. Uveitis mainly manifested as unilateral (74.5%), chronic course (82.4%), and panuveitis (43.1%). Ocular toxoplasmosis and toxocariasis were the most common diagnoses (9.8% each). At least one ocular complication at presentation was observed in 93% of the eyes. Overall, the mean logMAR VA improved from 1.8 at presentation to 1.2 at 5 years (P < 0.001). Common causes of poor vision included retinal detachment, atrophic bulbi, and optic atrophy. Predictive factors associated with less VA improvement over the follow-up period included preschool age of uveitis onset (P < 0.001), ocular symptoms duration before uveitis diagnosis ≥ 1 month (P = 0.004), and non-anterior uveitis (P = 0.047). The long-term VA outcome in uveitis-affected eyes with SVI at presentation was unfavorable. Younger age at uveitis onset, delayed presentation, and uveitis involving the posterior segment were associated with poorer VA outcome.https://doi.org/10.1038/s41598-023-29159-x |
| spellingShingle | Usanee Tungsattayathitthan Narisa Rattanalert Wantanee Sittivarakul Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment Scientific Reports |
| title | Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment |
| title_full | Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment |
| title_fullStr | Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment |
| title_full_unstemmed | Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment |
| title_short | Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment |
| title_sort | long term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment |
| url | https://doi.org/10.1038/s41598-023-29159-x |
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