Influence of prenatal exercise on the relationship between maternal overweight and obesity and select delivery outcomes
Abstract Women with overweight or obesity (OWOB) have an increased risk of cesarean birth, preterm birth (PTB), and high birth weight infants. Although regular exercise decreases this risk in healthy weight women, these associations have not been explored in OWOB. Women were randomized at 13–16 week...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22283-0 |
| _version_ | 1828723407266512896 |
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| author | Samantha M. McDonald Steven Mouro Breanna Wisseman Christy Isler James DeVente Edward Newton Jason Hildebrand Devon Kuehn George Kelley Lisa Chasan-Taber Nicholas T. Broskey Linda E. May |
| author_facet | Samantha M. McDonald Steven Mouro Breanna Wisseman Christy Isler James DeVente Edward Newton Jason Hildebrand Devon Kuehn George Kelley Lisa Chasan-Taber Nicholas T. Broskey Linda E. May |
| author_sort | Samantha M. McDonald |
| collection | DOAJ |
| description | Abstract Women with overweight or obesity (OWOB) have an increased risk of cesarean birth, preterm birth (PTB), and high birth weight infants. Although regular exercise decreases this risk in healthy weight women, these associations have not been explored in OWOB. Women were randomized at 13–16 weeks’ gestation to 150-min of moderate-intensity exercise (n = 131) or non-exercising control (n = 61). Delivery mode, gestational age (GA), and birth weight (BW) were obtained via electronic health records. Pregnant exercisers had no differences in risk of cesarean birth, PTB, or BW compared to control participants. OWOB exercisers had higher rates of cesarean birth (27.1% vs. 11.1%), trends of higher PTB (15.3% vs. 5.6%), but normal weight babies relative to normal weight exercisers. Controlling for race and body mass index (BMI), maternal exercise reduced the relative risk (RR) for cesarean birth from 1.63 to 1.43. Cesarean births predicted by pre-pregnancy BMI and fitness level, whereas BW was predicted by race, gestational weight gain (GWG), pre-pregnancy fitness level, and exercise level. Cesarean birth was predicted by pre-pregnancy BMI and fitness level, while maternal exercise reduced the magnitudes of the relative risks of cesarean birth. Maternal exercise, pre-pregnancy fitness level, and GWG predict neonatal BW. Trial Registration: Influence of Maternal Exercise on Infant Skeletal Muscle and Metabolomics-#NCT03838146, 12/02/2019, https://register.clinicaltrials.gov/prs/app/template/EditRecord.vm?epmode=Edit&listmode=Edit&uid=U0003Z0X&ts=8&sid=S0008FWJ&cx=77ud1i . |
| first_indexed | 2024-04-12T12:49:30Z |
| format | Article |
| id | doaj.art-526228f6a7c34540a4315e7c5e3ca0f6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T12:49:30Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-526228f6a7c34540a4315e7c5e3ca0f62022-12-22T03:32:31ZengNature PortfolioScientific Reports2045-23222022-10-011211910.1038/s41598-022-22283-0Influence of prenatal exercise on the relationship between maternal overweight and obesity and select delivery outcomesSamantha M. McDonald0Steven Mouro1Breanna Wisseman2Christy Isler3James DeVente4Edward Newton5Jason Hildebrand6Devon Kuehn7George Kelley8Lisa Chasan-Taber9Nicholas T. Broskey10Linda E. May11School of Kinesiology and Recreation, Illinois State UniversityCampbell University School of Osteopathic MedicineHuman Performance Laboratory, East Carolina University (ECU)Department of Obstetrics and Gynecology, ECUDepartment of Obstetrics and Gynecology, ECUDepartment of Obstetrics and Gynecology, ECUDepartment of Obstetrics and Gynecology, ECUDepartment of Pediatrics, ECUDepartment of Epidemiology and Biostatistics, West Virginia UniversityDepartment of Biostatistics and Epidemiology, University of MassachusettsHuman Performance Laboratory, East Carolina University (ECU)Department of Obstetrics and Gynecology, ECUAbstract Women with overweight or obesity (OWOB) have an increased risk of cesarean birth, preterm birth (PTB), and high birth weight infants. Although regular exercise decreases this risk in healthy weight women, these associations have not been explored in OWOB. Women were randomized at 13–16 weeks’ gestation to 150-min of moderate-intensity exercise (n = 131) or non-exercising control (n = 61). Delivery mode, gestational age (GA), and birth weight (BW) were obtained via electronic health records. Pregnant exercisers had no differences in risk of cesarean birth, PTB, or BW compared to control participants. OWOB exercisers had higher rates of cesarean birth (27.1% vs. 11.1%), trends of higher PTB (15.3% vs. 5.6%), but normal weight babies relative to normal weight exercisers. Controlling for race and body mass index (BMI), maternal exercise reduced the relative risk (RR) for cesarean birth from 1.63 to 1.43. Cesarean births predicted by pre-pregnancy BMI and fitness level, whereas BW was predicted by race, gestational weight gain (GWG), pre-pregnancy fitness level, and exercise level. Cesarean birth was predicted by pre-pregnancy BMI and fitness level, while maternal exercise reduced the magnitudes of the relative risks of cesarean birth. Maternal exercise, pre-pregnancy fitness level, and GWG predict neonatal BW. Trial Registration: Influence of Maternal Exercise on Infant Skeletal Muscle and Metabolomics-#NCT03838146, 12/02/2019, https://register.clinicaltrials.gov/prs/app/template/EditRecord.vm?epmode=Edit&listmode=Edit&uid=U0003Z0X&ts=8&sid=S0008FWJ&cx=77ud1i .https://doi.org/10.1038/s41598-022-22283-0 |
| spellingShingle | Samantha M. McDonald Steven Mouro Breanna Wisseman Christy Isler James DeVente Edward Newton Jason Hildebrand Devon Kuehn George Kelley Lisa Chasan-Taber Nicholas T. Broskey Linda E. May Influence of prenatal exercise on the relationship between maternal overweight and obesity and select delivery outcomes Scientific Reports |
| title | Influence of prenatal exercise on the relationship between maternal overweight and obesity and select delivery outcomes |
| title_full | Influence of prenatal exercise on the relationship between maternal overweight and obesity and select delivery outcomes |
| title_fullStr | Influence of prenatal exercise on the relationship between maternal overweight and obesity and select delivery outcomes |
| title_full_unstemmed | Influence of prenatal exercise on the relationship between maternal overweight and obesity and select delivery outcomes |
| title_short | Influence of prenatal exercise on the relationship between maternal overweight and obesity and select delivery outcomes |
| title_sort | influence of prenatal exercise on the relationship between maternal overweight and obesity and select delivery outcomes |
| url | https://doi.org/10.1038/s41598-022-22283-0 |
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