Obesity-induced asthma: Role of free fatty acid receptors
Obesity is a major risk factor for the development of asthma, and worsens the key features of asthma including airway hyperresponsiveness, inflammation, and airway remodeling. Although pro- and anti-inflammatory adipocytokines may contribute to the pathogenesis of asthma in obesity, the mechanistic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-11-01
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| Series: | Japanese Dental Science Review |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S188276161830019X |
| _version_ | 1818853804592857088 |
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| author | Kentaro Mizuta Atsuko Matoba Sumire Shibata Eiji Masaki Charles W. Emala Sr |
| author_facet | Kentaro Mizuta Atsuko Matoba Sumire Shibata Eiji Masaki Charles W. Emala Sr |
| author_sort | Kentaro Mizuta |
| collection | DOAJ |
| description | Obesity is a major risk factor for the development of asthma, and worsens the key features of asthma including airway hyperresponsiveness, inflammation, and airway remodeling. Although pro- and anti-inflammatory adipocytokines may contribute to the pathogenesis of asthma in obesity, the mechanistic basis for the relationship between asthma and obesity remains unclear. In obese individuals, the increased amount of adipose tissue results in the release of more long-chain free fatty acids as compared to lean individuals, causing an elevation in plasma long-chain free fatty acid concentrations. Recent findings suggest that the free fatty acid receptor 1 (FFAR1), which is a sensor of medium- and long-chain free fatty acids, is expressed on airway smooth muscle and plays a pivotal role in airway contraction and airway smooth muscle cell proliferation. In contrast, FFAR4, which is a sensor for long-chain n-3 polyunsaturated fatty acids and also expressed on airway smooth muscle, does not contribute to airway contraction and airway smooth muscle cell proliferation. Functional roles for short-chain fatty acid receptors FFAR2 and FFAR3 in the pathogenesis of asthma is still under debate. Taken together, adipose-derived long-chain free fatty acids may contribute to the pathogenesis of asthma in obesity through FFAR1. Keywords: Asthma, Obesity, Free fatty acid receptor, Airway smooth muscle |
| first_indexed | 2024-12-19T07:42:38Z |
| format | Article |
| id | doaj.art-5263f2d30f1247e3a8206f2547d9c506 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-12-19T07:42:38Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-5263f2d30f1247e3a8206f2547d9c5062022-12-21T20:30:25ZengElsevierJapanese Dental Science Review1882-76162019-11-01551103107Obesity-induced asthma: Role of free fatty acid receptorsKentaro Mizuta0Atsuko Matoba1Sumire Shibata2Eiji Masaki3Charles W. Emala Sr4Department of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, Sendai, Japan; Corresponding author.Department of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, Sendai, JapanDepartment of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, Sendai, JapanDepartment of Dento-oral Anesthesiology, Tohoku University Graduate School of Dentistry, Sendai, JapanDepartment of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York, United StatesObesity is a major risk factor for the development of asthma, and worsens the key features of asthma including airway hyperresponsiveness, inflammation, and airway remodeling. Although pro- and anti-inflammatory adipocytokines may contribute to the pathogenesis of asthma in obesity, the mechanistic basis for the relationship between asthma and obesity remains unclear. In obese individuals, the increased amount of adipose tissue results in the release of more long-chain free fatty acids as compared to lean individuals, causing an elevation in plasma long-chain free fatty acid concentrations. Recent findings suggest that the free fatty acid receptor 1 (FFAR1), which is a sensor of medium- and long-chain free fatty acids, is expressed on airway smooth muscle and plays a pivotal role in airway contraction and airway smooth muscle cell proliferation. In contrast, FFAR4, which is a sensor for long-chain n-3 polyunsaturated fatty acids and also expressed on airway smooth muscle, does not contribute to airway contraction and airway smooth muscle cell proliferation. Functional roles for short-chain fatty acid receptors FFAR2 and FFAR3 in the pathogenesis of asthma is still under debate. Taken together, adipose-derived long-chain free fatty acids may contribute to the pathogenesis of asthma in obesity through FFAR1. Keywords: Asthma, Obesity, Free fatty acid receptor, Airway smooth musclehttp://www.sciencedirect.com/science/article/pii/S188276161830019X |
| spellingShingle | Kentaro Mizuta Atsuko Matoba Sumire Shibata Eiji Masaki Charles W. Emala Sr Obesity-induced asthma: Role of free fatty acid receptors Japanese Dental Science Review |
| title | Obesity-induced asthma: Role of free fatty acid receptors |
| title_full | Obesity-induced asthma: Role of free fatty acid receptors |
| title_fullStr | Obesity-induced asthma: Role of free fatty acid receptors |
| title_full_unstemmed | Obesity-induced asthma: Role of free fatty acid receptors |
| title_short | Obesity-induced asthma: Role of free fatty acid receptors |
| title_sort | obesity induced asthma role of free fatty acid receptors |
| url | http://www.sciencedirect.com/science/article/pii/S188276161830019X |
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