Preserving the Integrity of Liposomes Prepared by Ethanol Injection upon Freeze-Drying: Insights from Combined Molecular Dynamics Simulations and Experimental Data

Preserving the Integrity of Liposomes Prepared by Ethanol Injection upon Freeze-Drying: Insights from Combined Molecular Dynamics Simulations and Experimental Data

The freeze-drying of complex formulations, such as liposomes, is challenging, particularly if dispersions contain residual organic solvents. This work aimed to investigate the effects of possible protectants, namely sucrose, trehalose and/or poly(vinyl pyrrolidone) (PVP), on the main features of the...

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Bibliographic Details
Main Authors: Silvia Franzè, Francesca Selmin, Paolo Rocco, Giuseppe Colombo, Antonella Casiraghi, Francesco Cilurzo
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
cake appearance
cryoprotectant
freeze-drying
freezing rate
liposomes
lyoprotectant
Online Access:https://www.mdpi.com/1999-4923/12/6/530

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