The functional effects of Piezo channels in mesenchymal stem cells
Abstract Mesenchymal stem cells (MSCs) are widely used in cell therapy, tissue engineering, and regenerative medicine because of their self-renewal, pluripotency, and immunomodulatory properties. The microenvironment in which MSCs are located significantly affects their physiological functions. The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03452-y |
| _version_ | 1797453689196118016 |
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| author | Zhilong Huang Yingying Huang Xiner Ning Haodi Li Qiqi Li Junjie Wu |
| author_facet | Zhilong Huang Yingying Huang Xiner Ning Haodi Li Qiqi Li Junjie Wu |
| author_sort | Zhilong Huang |
| collection | DOAJ |
| description | Abstract Mesenchymal stem cells (MSCs) are widely used in cell therapy, tissue engineering, and regenerative medicine because of their self-renewal, pluripotency, and immunomodulatory properties. The microenvironment in which MSCs are located significantly affects their physiological functions. The microenvironment directly or indirectly affects cell behavior through biophysical, biochemical, or other means. Among them, the mechanical signals provided to MSCs by the microenvironment have a particularly pronounced effect on their physiological functions and can affect osteogenic differentiation, chondrogenic differentiation, and senescence in MSCs. Mechanosensitive ion channels such as Piezo1 and Piezo2 are important in transducing mechanical signals, and these channels are widely distributed in sites such as skin, bladder, kidney, lung, sensory neurons, and dorsal root ganglia. Although there have been numerous studies on Piezo channels in MSCs in recent years, the function of Piezo channels in MSCs is still not well understood, and there has been no summary of their relationship to illustrate which physiological functions of MSCs are affected by Piezo channels and the possible underlying mechanisms. Therefore, based on the members, structures, and functions of Piezo ion channels and the fundamental information of MSCs, this paper focused on summarizing the advances in Piezo channels in MSCs from various tissue sources to provide new ideas for future research and practical applications of Piezo channels and MSCs. |
| first_indexed | 2024-03-09T15:26:14Z |
| format | Article |
| id | doaj.art-5264c153151f47d98d76d6e8be059a0b |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-03-09T15:26:14Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-5264c153151f47d98d76d6e8be059a0b2023-11-26T12:31:07ZengBMCStem Cell Research & Therapy1757-65122023-08-0114111310.1186/s13287-023-03452-yThe functional effects of Piezo channels in mesenchymal stem cellsZhilong Huang0Yingying Huang1Xiner Ning2Haodi Li3Qiqi Li4Junjie Wu5State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical UniversityAbstract Mesenchymal stem cells (MSCs) are widely used in cell therapy, tissue engineering, and regenerative medicine because of their self-renewal, pluripotency, and immunomodulatory properties. The microenvironment in which MSCs are located significantly affects their physiological functions. The microenvironment directly or indirectly affects cell behavior through biophysical, biochemical, or other means. Among them, the mechanical signals provided to MSCs by the microenvironment have a particularly pronounced effect on their physiological functions and can affect osteogenic differentiation, chondrogenic differentiation, and senescence in MSCs. Mechanosensitive ion channels such as Piezo1 and Piezo2 are important in transducing mechanical signals, and these channels are widely distributed in sites such as skin, bladder, kidney, lung, sensory neurons, and dorsal root ganglia. Although there have been numerous studies on Piezo channels in MSCs in recent years, the function of Piezo channels in MSCs is still not well understood, and there has been no summary of their relationship to illustrate which physiological functions of MSCs are affected by Piezo channels and the possible underlying mechanisms. Therefore, based on the members, structures, and functions of Piezo ion channels and the fundamental information of MSCs, this paper focused on summarizing the advances in Piezo channels in MSCs from various tissue sources to provide new ideas for future research and practical applications of Piezo channels and MSCs.https://doi.org/10.1186/s13287-023-03452-yPiezo1Piezo2Mechanosensitive ion channelsMechanotransductionMesenchymal stem cells |
| spellingShingle | Zhilong Huang Yingying Huang Xiner Ning Haodi Li Qiqi Li Junjie Wu The functional effects of Piezo channels in mesenchymal stem cells Stem Cell Research & Therapy Piezo1 Piezo2 Mechanosensitive ion channels Mechanotransduction Mesenchymal stem cells |
| title | The functional effects of Piezo channels in mesenchymal stem cells |
| title_full | The functional effects of Piezo channels in mesenchymal stem cells |
| title_fullStr | The functional effects of Piezo channels in mesenchymal stem cells |
| title_full_unstemmed | The functional effects of Piezo channels in mesenchymal stem cells |
| title_short | The functional effects of Piezo channels in mesenchymal stem cells |
| title_sort | functional effects of piezo channels in mesenchymal stem cells |
| topic | Piezo1 Piezo2 Mechanosensitive ion channels Mechanotransduction Mesenchymal stem cells |
| url | https://doi.org/10.1186/s13287-023-03452-y |
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