Update on Nonhuman Primate Models of Brain Disease and Related Research Tools
The aging of the population is an increasingly serious issue, and many age-related illnesses are on the rise. These illnesses pose a serious threat to the health and safety of elderly individuals and create a serious economic and social burden. Despite substantial research into the pathogenesis of t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/9/2516 |
| _version_ | 1797581088699187200 |
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| author | Nan Qiao Lizhen Ma Yi Zhang Lifeng Wang |
| author_facet | Nan Qiao Lizhen Ma Yi Zhang Lifeng Wang |
| author_sort | Nan Qiao |
| collection | DOAJ |
| description | The aging of the population is an increasingly serious issue, and many age-related illnesses are on the rise. These illnesses pose a serious threat to the health and safety of elderly individuals and create a serious economic and social burden. Despite substantial research into the pathogenesis of these diseases, their etiology and pathogenesis remain unclear. In recent decades, rodent models have been used in attempts to elucidate these disorders, but such models fail to simulate the full range of symptoms. Nonhuman primates (NHPs) are the most ideal neuroscientific models for studying the human brain and are more functionally similar to humans because of their high genetic similarities and phenotypic characteristics in comparison with humans. Here, we review the literature examining typical NHP brain disease models, focusing on NHP models of common diseases such as dementia, Parkinson’s disease, and epilepsy. We also explore the application of electroencephalography (EEG), magnetic resonance imaging (MRI), and optogenetic study methods on NHPs and neural circuits associated with cognitive impairment. |
| first_indexed | 2024-03-10T23:00:11Z |
| format | Article |
| id | doaj.art-526639c446fa48b7aae89e29613a89c3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T23:00:11Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-526639c446fa48b7aae89e29613a89c32023-11-19T09:42:26ZengMDPI AGBiomedicines2227-90592023-09-01119251610.3390/biomedicines11092516Update on Nonhuman Primate Models of Brain Disease and Related Research ToolsNan Qiao0Lizhen Ma1Yi Zhang2Lifeng Wang3School of Life Sciences, Hebei University, 180 Wusi Dong Lu, Baoding 071002, ChinaBeijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, ChinaSchool of Life Sciences, Hebei University, 180 Wusi Dong Lu, Baoding 071002, ChinaSchool of Life Sciences, Hebei University, 180 Wusi Dong Lu, Baoding 071002, ChinaThe aging of the population is an increasingly serious issue, and many age-related illnesses are on the rise. These illnesses pose a serious threat to the health and safety of elderly individuals and create a serious economic and social burden. Despite substantial research into the pathogenesis of these diseases, their etiology and pathogenesis remain unclear. In recent decades, rodent models have been used in attempts to elucidate these disorders, but such models fail to simulate the full range of symptoms. Nonhuman primates (NHPs) are the most ideal neuroscientific models for studying the human brain and are more functionally similar to humans because of their high genetic similarities and phenotypic characteristics in comparison with humans. Here, we review the literature examining typical NHP brain disease models, focusing on NHP models of common diseases such as dementia, Parkinson’s disease, and epilepsy. We also explore the application of electroencephalography (EEG), magnetic resonance imaging (MRI), and optogenetic study methods on NHPs and neural circuits associated with cognitive impairment.https://www.mdpi.com/2227-9059/11/9/2516NHPsbrain disease modelsEEGMRIoptogeneticsneural circuits |
| spellingShingle | Nan Qiao Lizhen Ma Yi Zhang Lifeng Wang Update on Nonhuman Primate Models of Brain Disease and Related Research Tools Biomedicines NHPs brain disease models EEG MRI optogenetics neural circuits |
| title | Update on Nonhuman Primate Models of Brain Disease and Related Research Tools |
| title_full | Update on Nonhuman Primate Models of Brain Disease and Related Research Tools |
| title_fullStr | Update on Nonhuman Primate Models of Brain Disease and Related Research Tools |
| title_full_unstemmed | Update on Nonhuman Primate Models of Brain Disease and Related Research Tools |
| title_short | Update on Nonhuman Primate Models of Brain Disease and Related Research Tools |
| title_sort | update on nonhuman primate models of brain disease and related research tools |
| topic | NHPs brain disease models EEG MRI optogenetics neural circuits |
| url | https://www.mdpi.com/2227-9059/11/9/2516 |
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