Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis
Microplastics (MPs), an emerging group of pollutants, not only have direct toxic effects on aquatic organisms but also cause combined toxicity by absorbing other pollutants. Triphenyltin (TPT), one of the most widely used organotin compounds, has adverse effects on aquatic organisms. However, little...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Environmental Science and Ecotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666498423000315 |
| _version_ | 1797791872177930240 |
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| author | Si-Qi Zhang Ping Li Shu-Wen He Shao-Ying Xing Zhi-Han Cao Xue-Li Zhao Cuici Sun Zhi-Hua Li |
| author_facet | Si-Qi Zhang Ping Li Shu-Wen He Shao-Ying Xing Zhi-Han Cao Xue-Li Zhao Cuici Sun Zhi-Hua Li |
| author_sort | Si-Qi Zhang |
| collection | DOAJ |
| description | Microplastics (MPs), an emerging group of pollutants, not only have direct toxic effects on aquatic organisms but also cause combined toxicity by absorbing other pollutants. Triphenyltin (TPT), one of the most widely used organotin compounds, has adverse effects on aquatic organisms. However, little is known about the combined toxicity of MPs and TPT to aquatic organisms. To investigate the individual and combined toxicity of MPs and TPT, we selected the common carp (Cyprinus carpio) for a 42-day exposure experiment. Based on the environmental concentrations in a heavily polluted area, the experimental concentrations of MPs and TPT were set at 0.5 mg L−1 and 1 μg L−1, respectively. The effects of MPs combined with TPT on the carp gut–brain axis were evaluated by detecting gut physiology and biochemical parameters, gut microbial 16S rRNA, and brain transcriptome sequencing. Our results suggest that a single TPT caused lipid metabolism disorder and a single MP induced immunosuppression in carp. When MPs were combined with TPT, the involvement of TPT amplified the immunotoxic effect induced by MPs. In this study, we also explored the gut–brain axis relationship of carp immunosuppression, providing new insights for assessing the combined toxicity of MPs and TPT. At the same time, our study provides a theoretical basis for evaluating the coexistence risk of MPs and TPT in the aquatic environment. |
| first_indexed | 2024-03-13T02:25:00Z |
| format | Article |
| id | doaj.art-52664389665140d8bf5081d37422dfba |
| institution | Directory Open Access Journal |
| issn | 2666-4984 |
| language | English |
| last_indexed | 2024-03-13T02:25:00Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environmental Science and Ecotechnology |
| spelling | doaj.art-52664389665140d8bf5081d37422dfba2023-06-30T04:22:56ZengElsevierEnvironmental Science and Ecotechnology2666-49842023-10-0116100266Combined effect of microplastic and triphenyltin: Insights from the gut-brain axisSi-Qi Zhang0Ping Li1Shu-Wen He2Shao-Ying Xing3Zhi-Han Cao4Xue-Li Zhao5Cuici Sun6Zhi-Hua Li7Marine College, Shandong University, Weihai, Shandong, 264209, China; State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 510301, Guangzhou, ChinaMarine College, Shandong University, Weihai, Shandong, 264209, ChinaMarine College, Shandong University, Weihai, Shandong, 264209, ChinaMarine College, Shandong University, Weihai, Shandong, 264209, ChinaMarine College, Shandong University, Weihai, Shandong, 264209, ChinaMarine College, Shandong University, Weihai, Shandong, 264209, ChinaState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 510301, Guangzhou, ChinaMarine College, Shandong University, Weihai, Shandong, 264209, China; Corresponding author. Marine College, Shandong University, Weihai, 264209, China.Microplastics (MPs), an emerging group of pollutants, not only have direct toxic effects on aquatic organisms but also cause combined toxicity by absorbing other pollutants. Triphenyltin (TPT), one of the most widely used organotin compounds, has adverse effects on aquatic organisms. However, little is known about the combined toxicity of MPs and TPT to aquatic organisms. To investigate the individual and combined toxicity of MPs and TPT, we selected the common carp (Cyprinus carpio) for a 42-day exposure experiment. Based on the environmental concentrations in a heavily polluted area, the experimental concentrations of MPs and TPT were set at 0.5 mg L−1 and 1 μg L−1, respectively. The effects of MPs combined with TPT on the carp gut–brain axis were evaluated by detecting gut physiology and biochemical parameters, gut microbial 16S rRNA, and brain transcriptome sequencing. Our results suggest that a single TPT caused lipid metabolism disorder and a single MP induced immunosuppression in carp. When MPs were combined with TPT, the involvement of TPT amplified the immunotoxic effect induced by MPs. In this study, we also explored the gut–brain axis relationship of carp immunosuppression, providing new insights for assessing the combined toxicity of MPs and TPT. At the same time, our study provides a theoretical basis for evaluating the coexistence risk of MPs and TPT in the aquatic environment.http://www.sciencedirect.com/science/article/pii/S2666498423000315Aquatic organismCombined toxicityEcological riskEnvironmental concentration |
| spellingShingle | Si-Qi Zhang Ping Li Shu-Wen He Shao-Ying Xing Zhi-Han Cao Xue-Li Zhao Cuici Sun Zhi-Hua Li Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis Environmental Science and Ecotechnology Aquatic organism Combined toxicity Ecological risk Environmental concentration |
| title | Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis |
| title_full | Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis |
| title_fullStr | Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis |
| title_full_unstemmed | Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis |
| title_short | Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis |
| title_sort | combined effect of microplastic and triphenyltin insights from the gut brain axis |
| topic | Aquatic organism Combined toxicity Ecological risk Environmental concentration |
| url | http://www.sciencedirect.com/science/article/pii/S2666498423000315 |
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