Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.
CD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets. In the context of genital tract infection...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4847787?pdf=render |
| _version_ | 1818524928194904064 |
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| author | Jamal Qualai Lin-Xi Li Jon Cantero Antoni Tarrats Marco Antonio Fernández Lauro Sumoy Annie Rodolosse Stephen J McSorley Meritxell Genescà |
| author_facet | Jamal Qualai Lin-Xi Li Jon Cantero Antoni Tarrats Marco Antonio Fernández Lauro Sumoy Annie Rodolosse Stephen J McSorley Meritxell Genescà |
| author_sort | Jamal Qualai |
| collection | DOAJ |
| description | CD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets. In the context of genital tract infection, we have previously observed increased expression of CD11c in circulating T cells from mice and women. Microarray analyses of activated effector T cells expressing CD11c derived from naïve mice demonstrated enrichment for natural killer (NK) associated genes. Here we find that murine CD11c+ T cells analyzed by flow cytometry display markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T (iNKT) cells. However, in women, only γδ T cells and CD8+ T cells were enriched within the CD11c fraction of blood and cervical tissue. These CD11c+ cells were highly activated and had greater interferon (IFN)-γ secretory capacity than CD11c- T cells. Furthermore, circulating CD11c+ T cells were associated with the expression of multiple adhesion molecules in women, suggesting that these cells have high tissue homing potential. These data suggest that CD11c expression distinguishes a population of circulating T cells during bacterial infection with innate capacity and mucosal homing potential. |
| first_indexed | 2024-12-11T06:03:10Z |
| format | Article |
| id | doaj.art-5267c7fe83cc43769e1d05543c1098dd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T06:03:10Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5267c7fe83cc43769e1d05543c1098dd2022-12-22T01:18:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015425310.1371/journal.pone.0154253Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.Jamal QualaiLin-Xi LiJon CanteroAntoni TarratsMarco Antonio FernándezLauro SumoyAnnie RodolosseStephen J McSorleyMeritxell GenescàCD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets. In the context of genital tract infection, we have previously observed increased expression of CD11c in circulating T cells from mice and women. Microarray analyses of activated effector T cells expressing CD11c derived from naïve mice demonstrated enrichment for natural killer (NK) associated genes. Here we find that murine CD11c+ T cells analyzed by flow cytometry display markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T (iNKT) cells. However, in women, only γδ T cells and CD8+ T cells were enriched within the CD11c fraction of blood and cervical tissue. These CD11c+ cells were highly activated and had greater interferon (IFN)-γ secretory capacity than CD11c- T cells. Furthermore, circulating CD11c+ T cells were associated with the expression of multiple adhesion molecules in women, suggesting that these cells have high tissue homing potential. These data suggest that CD11c expression distinguishes a population of circulating T cells during bacterial infection with innate capacity and mucosal homing potential.http://europepmc.org/articles/PMC4847787?pdf=render |
| spellingShingle | Jamal Qualai Lin-Xi Li Jon Cantero Antoni Tarrats Marco Antonio Fernández Lauro Sumoy Annie Rodolosse Stephen J McSorley Meritxell Genescà Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. PLoS ONE |
| title | Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. |
| title_full | Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. |
| title_fullStr | Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. |
| title_full_unstemmed | Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. |
| title_short | Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. |
| title_sort | expression of cd11c is associated with unconventional activated t cell subsets with high migratory potential |
| url | http://europepmc.org/articles/PMC4847787?pdf=render |
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