An Overview of Genetic Information of Latent Mycobacterium tuberculosis
Mycobacterium tuberculosis has infected more than two billion individuals worldwide, of whom 5%–10% have clinically active disease and 90%–95% remain in the latent stage with a reservoir of viable bacteria in the macrophages for extended periods of time. The tubercle bacilli at this stage are usuall...
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| Format: | Article |
| Language: | English |
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The Korean Academy of Tuberculosis and Respiratory Diseases
2021-01-01
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| Series: | Tuberculosis and Respiratory Diseases |
| Subjects: | |
| Online Access: | http://www.e-trd.org/upload/pdf/trd-2020-0116.pdf |
| _version_ | 1818351363916038144 |
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| author | Faezeh Hamidieh Parissa Farnia Jamileh Nowroozi Poopak Farnia Ali Akbar Velayati |
| author_facet | Faezeh Hamidieh Parissa Farnia Jamileh Nowroozi Poopak Farnia Ali Akbar Velayati |
| author_sort | Faezeh Hamidieh |
| collection | DOAJ |
| description | Mycobacterium tuberculosis has infected more than two billion individuals worldwide, of whom 5%–10% have clinically active disease and 90%–95% remain in the latent stage with a reservoir of viable bacteria in the macrophages for extended periods of time. The tubercle bacilli at this stage are usually called dormant, non-viable, and/or non-culturable microorganisms. The patients with latent bacilli will not have clinical pictures and are not infectious. The infections in about 2%–23% of the patients with latent status become reactivated for various reasons such as cancer, human immunodeficiency virus infection, diabetes, and/or aging. Many studies have examined the mechanisms involved in the latent state of Mycobacterium and showed that latency modified the expression of many genes. Therefore, several mechanisms will change in this bacterium. Hence, this study aimed to briefly examine the genes involved in the latent state as well as the changes that are caused by Mycobacterium tuberculosis. The study also evaluated the relationship between the functions of these genes. |
| first_indexed | 2024-12-13T18:36:33Z |
| format | Article |
| id | doaj.art-5267ce466be94d988eed12d33a2771c1 |
| institution | Directory Open Access Journal |
| issn | 1738-3536 2005-6184 |
| language | English |
| last_indexed | 2024-12-13T18:36:33Z |
| publishDate | 2021-01-01 |
| publisher | The Korean Academy of Tuberculosis and Respiratory Diseases |
| record_format | Article |
| series | Tuberculosis and Respiratory Diseases |
| spelling | doaj.art-5267ce466be94d988eed12d33a2771c12022-12-21T23:35:21ZengThe Korean Academy of Tuberculosis and Respiratory DiseasesTuberculosis and Respiratory Diseases1738-35362005-61842021-01-0184111210.4046/trd.2020.01163282An Overview of Genetic Information of Latent Mycobacterium tuberculosisFaezeh Hamidieh0Parissa Farnia1Jamileh Nowroozi2Poopak Farnia3Ali Akbar Velayati4 Departement of Microbiology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran Mycobacteriology Research (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Departement of Microbiology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran Mycobacteriology Research (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Mycobacteriology Research (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranMycobacterium tuberculosis has infected more than two billion individuals worldwide, of whom 5%–10% have clinically active disease and 90%–95% remain in the latent stage with a reservoir of viable bacteria in the macrophages for extended periods of time. The tubercle bacilli at this stage are usually called dormant, non-viable, and/or non-culturable microorganisms. The patients with latent bacilli will not have clinical pictures and are not infectious. The infections in about 2%–23% of the patients with latent status become reactivated for various reasons such as cancer, human immunodeficiency virus infection, diabetes, and/or aging. Many studies have examined the mechanisms involved in the latent state of Mycobacterium and showed that latency modified the expression of many genes. Therefore, several mechanisms will change in this bacterium. Hence, this study aimed to briefly examine the genes involved in the latent state as well as the changes that are caused by Mycobacterium tuberculosis. The study also evaluated the relationship between the functions of these genes.http://www.e-trd.org/upload/pdf/trd-2020-0116.pdflatencytuberculosisdormancyhypoxic conditions |
| spellingShingle | Faezeh Hamidieh Parissa Farnia Jamileh Nowroozi Poopak Farnia Ali Akbar Velayati An Overview of Genetic Information of Latent Mycobacterium tuberculosis Tuberculosis and Respiratory Diseases latency tuberculosis dormancy hypoxic conditions |
| title | An Overview of Genetic Information of Latent Mycobacterium tuberculosis |
| title_full | An Overview of Genetic Information of Latent Mycobacterium tuberculosis |
| title_fullStr | An Overview of Genetic Information of Latent Mycobacterium tuberculosis |
| title_full_unstemmed | An Overview of Genetic Information of Latent Mycobacterium tuberculosis |
| title_short | An Overview of Genetic Information of Latent Mycobacterium tuberculosis |
| title_sort | overview of genetic information of latent mycobacterium tuberculosis |
| topic | latency tuberculosis dormancy hypoxic conditions |
| url | http://www.e-trd.org/upload/pdf/trd-2020-0116.pdf |
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