Natural killer cells in inflammatory autoimmune diseases
Abstract Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytotoxicity, production of cytokines and chemokines, and migratory capacity, NK cells play a vital immunoregulatory role in the initiation and ch...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Clinical & Translational Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cti2.1250 |
| _version_ | 1818645477890981888 |
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| author | Yuyan Yang Jessica Day Fernando Souza‐Fonseca Guimaraes Ian P Wicks Cynthia Louis |
| author_facet | Yuyan Yang Jessica Day Fernando Souza‐Fonseca Guimaraes Ian P Wicks Cynthia Louis |
| author_sort | Yuyan Yang |
| collection | DOAJ |
| description | Abstract Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytotoxicity, production of cytokines and chemokines, and migratory capacity, NK cells play a vital immunoregulatory role in the initiation and chronicity of inflammatory and autoimmune responses. Our understanding of their functional differences and contributions in disease settings is evolving owing to new genetic and functional murine proof‐of‐concept studies. Here, we summarise current understanding of NK cells in several classic autoimmune disorders, particularly in rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1DM), but also less understood diseases such as idiopathic inflammatory myopathies (IIMs). A better understanding of how NK cells contribute to these autoimmune disorders may pave the way for NK cell‐targeted therapeutics. |
| first_indexed | 2024-12-17T00:31:22Z |
| format | Article |
| id | doaj.art-5267d08d7b4648849b9976491a429032 |
| institution | Directory Open Access Journal |
| issn | 2050-0068 |
| language | English |
| last_indexed | 2024-12-17T00:31:22Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical & Translational Immunology |
| spelling | doaj.art-5267d08d7b4648849b9976491a4290322022-12-21T22:10:17ZengWileyClinical & Translational Immunology2050-00682021-01-01102n/an/a10.1002/cti2.1250Natural killer cells in inflammatory autoimmune diseasesYuyan Yang0Jessica Day1Fernando Souza‐Fonseca Guimaraes2Ian P Wicks3Cynthia Louis4Tsinghua University School of Medicine Beijing ChinaInflammation Division The Walter and Eliza Hall Institute of Medical Research Parkville VIC AustraliaUniversity of Queensland Diamantina Institute Woolloongabba QLD AustraliaInflammation Division The Walter and Eliza Hall Institute of Medical Research Parkville VIC AustraliaInflammation Division The Walter and Eliza Hall Institute of Medical Research Parkville VIC AustraliaAbstract Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytotoxicity, production of cytokines and chemokines, and migratory capacity, NK cells play a vital immunoregulatory role in the initiation and chronicity of inflammatory and autoimmune responses. Our understanding of their functional differences and contributions in disease settings is evolving owing to new genetic and functional murine proof‐of‐concept studies. Here, we summarise current understanding of NK cells in several classic autoimmune disorders, particularly in rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1DM), but also less understood diseases such as idiopathic inflammatory myopathies (IIMs). A better understanding of how NK cells contribute to these autoimmune disorders may pave the way for NK cell‐targeted therapeutics.https://doi.org/10.1002/cti2.1250natural killer cellsautoimmune diseaserheumatoid arthritismultiple sclerosissystemic lupus erythematosustype 1 diabetes mellitus |
| spellingShingle | Yuyan Yang Jessica Day Fernando Souza‐Fonseca Guimaraes Ian P Wicks Cynthia Louis Natural killer cells in inflammatory autoimmune diseases Clinical & Translational Immunology natural killer cells autoimmune disease rheumatoid arthritis multiple sclerosis systemic lupus erythematosus type 1 diabetes mellitus |
| title | Natural killer cells in inflammatory autoimmune diseases |
| title_full | Natural killer cells in inflammatory autoimmune diseases |
| title_fullStr | Natural killer cells in inflammatory autoimmune diseases |
| title_full_unstemmed | Natural killer cells in inflammatory autoimmune diseases |
| title_short | Natural killer cells in inflammatory autoimmune diseases |
| title_sort | natural killer cells in inflammatory autoimmune diseases |
| topic | natural killer cells autoimmune disease rheumatoid arthritis multiple sclerosis systemic lupus erythematosus type 1 diabetes mellitus |
| url | https://doi.org/10.1002/cti2.1250 |
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