Vaccine prophylaxis of viral hepatitis in patients with acute leukemia
Aim. To assess efficacy of vaccine against viral hepatitis В (VHB) in adults after achievement of acute leukemia (AL) remission. Material and methods. Specific prevention of VHB was made in 30 AL patients with recombinant vaccine Engerix В by two schemes: 0-1-2-12 and 0-1-2-6 months with double adul...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2008-07-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30189 |
| _version_ | 1819005221207015424 |
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| author | N M Gurina E P Svedentsov V I Shardakov V V Cherepanova |
| author_facet | N M Gurina E P Svedentsov V I Shardakov V V Cherepanova |
| author_sort | N M Gurina |
| collection | DOAJ |
| description | Aim. To assess efficacy of vaccine against viral hepatitis В (VHB) in adults after achievement of acute leukemia (AL) remission. Material and methods. Specific prevention of VHB was made in 30 AL patients with recombinant vaccine Engerix В by two schemes: 0-1-2-12 and 0-1-2-6 months with double adult dose 40 mcg. Efficacy of vaccination was evaluated by the titer of antibodies to HBs-Ag (HBs-Ab) 1 month after each injection of the vaccine. The control group consisted of 36 patients. Follow-up was 6 months to 10 years. Results. Vaccine prophylaxis of VHB in AL remission resulted in appearance of the protective antibody titer after the forth vaccine injection in 50% patients. Out of 30 vaccinated patients 2 (6.7%) got infected with HBV 3 and 5 years after onset of the disease. Markers of HBV replication were detected in 8 (22%) of 36 patients. Conclusion. Vaccine prophylaxis of VHB in adult patients in AL remission was effective in 93.3% of the vaccinated patients. |
| first_indexed | 2024-12-20T23:49:20Z |
| format | Article |
| id | doaj.art-5269c4d2db96473988b83c462953a561 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-20T23:49:20Z |
| publishDate | 2008-07-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-5269c4d2db96473988b83c462953a5612022-12-21T19:22:52Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422008-07-01807272927216Vaccine prophylaxis of viral hepatitis in patients with acute leukemiaN M GurinaE P SvedentsovV I ShardakovV V CherepanovaAim. To assess efficacy of vaccine against viral hepatitis В (VHB) in adults after achievement of acute leukemia (AL) remission. Material and methods. Specific prevention of VHB was made in 30 AL patients with recombinant vaccine Engerix В by two schemes: 0-1-2-12 and 0-1-2-6 months with double adult dose 40 mcg. Efficacy of vaccination was evaluated by the titer of antibodies to HBs-Ag (HBs-Ab) 1 month after each injection of the vaccine. The control group consisted of 36 patients. Follow-up was 6 months to 10 years. Results. Vaccine prophylaxis of VHB in AL remission resulted in appearance of the protective antibody titer after the forth vaccine injection in 50% patients. Out of 30 vaccinated patients 2 (6.7%) got infected with HBV 3 and 5 years after onset of the disease. Markers of HBV replication were detected in 8 (22%) of 36 patients. Conclusion. Vaccine prophylaxis of VHB in adult patients in AL remission was effective in 93.3% of the vaccinated patients.https://ter-arkhiv.ru/0040-3660/article/view/30189vaccine prophylaxisviral hepatitis bacute leukemiapolychemotherapyantibodie |
| spellingShingle | N M Gurina E P Svedentsov V I Shardakov V V Cherepanova Vaccine prophylaxis of viral hepatitis in patients with acute leukemia Терапевтический архив vaccine prophylaxis viral hepatitis b acute leukemia polychemotherapy antibodie |
| title | Vaccine prophylaxis of viral hepatitis in patients with acute leukemia |
| title_full | Vaccine prophylaxis of viral hepatitis in patients with acute leukemia |
| title_fullStr | Vaccine prophylaxis of viral hepatitis in patients with acute leukemia |
| title_full_unstemmed | Vaccine prophylaxis of viral hepatitis in patients with acute leukemia |
| title_short | Vaccine prophylaxis of viral hepatitis in patients with acute leukemia |
| title_sort | vaccine prophylaxis of viral hepatitis in patients with acute leukemia |
| topic | vaccine prophylaxis viral hepatitis b acute leukemia polychemotherapy antibodie |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30189 |
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