Plasmodium vivax blood stage invasion pathways: Contribution of omics technologies in deciphering molecular and cellular mechanisms
Vivax malaria is an infectious disease caused by Plasmodium vivax, a parasitic protozoan transmitted by female Anopheline mosquitoes. Historically, vivax malaria has often been regarded as a benign self-limiting infection due to the observation of low parasitemia in Duffy-positive patients in endemi...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2022-11-01
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| Series: | Comptes Rendus Biologies |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.95/ |
| _version_ | 1797651242831314944 |
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| author | Bouyssou, Isabelle Martínez, Francisco José Campagne, Pascal Ma, Laurence Doderer-Lang, Cécile Chitnis, Chetan E. Ménard, Didier |
| author_facet | Bouyssou, Isabelle Martínez, Francisco José Campagne, Pascal Ma, Laurence Doderer-Lang, Cécile Chitnis, Chetan E. Ménard, Didier |
| author_sort | Bouyssou, Isabelle |
| collection | DOAJ |
| description | Vivax malaria is an infectious disease caused by Plasmodium vivax, a parasitic protozoan transmitted by female Anopheline mosquitoes. Historically, vivax malaria has often been regarded as a benign self-limiting infection due to the observation of low parasitemia in Duffy-positive patients in endemic transmission areas and the virtual absence of infections in Duffy-negative individuals in Sub Saharan Africa. However, the latest estimates show that the burden of the disease is not decreasing in many countries and cases of vivax infections in Duffy-negative individuals are increasingly reported throughout Africa. This raised questions about the accuracy of diagnostics and the evolution of interactions between humans and parasites. For a long time, our knowledge on P. vivax biology has been hampered due to the limited access to biological material and the lack of robust in vitro culture methods. Consequently, little is currently known about P. vivax blood stage invasion mechanisms. The introduction of omics technologies with novel and accessible techniques such as third generation sequencing and RNA sequencing at single cell level, two-dimensional electrophoresis, liquid chromatography, and mass spectrometry, has progressively improved our understanding of P. vivax genetics, transcripts, and proteins. This review aims to provide broad insights into P. vivax invasion mechanisms generated by genomics, transcriptomics, and proteomics and to illustrate the importance of integrated multi-omics studies. |
| first_indexed | 2024-03-11T16:13:06Z |
| format | Article |
| id | doaj.art-526a694d518e427caeee9b135b014fa7 |
| institution | Directory Open Access Journal |
| issn | 1768-3238 |
| language | English |
| last_indexed | 2024-03-11T16:13:06Z |
| publishDate | 2022-11-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj.art-526a694d518e427caeee9b135b014fa72023-10-24T14:25:24ZengAcadémie des sciencesComptes Rendus Biologies1768-32382022-11-0134529113310.5802/crbiol.9510.5802/crbiol.95Plasmodium vivax blood stage invasion pathways: Contribution of omics technologies in deciphering molecular and cellular mechanismsBouyssou, Isabelle0https://orcid.org/0000-0002-2391-4206Martínez, Francisco José1https://orcid.org/0000-0002-2827-0497Campagne, Pascal2https://orcid.org/0000-0001-7018-1896Ma, Laurence3https://orcid.org/0000-0003-4050-1814Doderer-Lang, Cécile4https://orcid.org/0000-0001-8786-6728Chitnis, Chetan E.5https://orcid.org/0000-0002-8773-9865Ménard, Didier6https://orcid.org/0000-0003-1357-4495Institut Pasteur, Université Paris Cité, Malaria Genetics and Resistance Unit, INSERM U1201, F-75015 Paris, France; Sorbonne Université, École Doctorale ED515 ‘Complexité du Vivant’, F-75005 Paris, FranceInstitut Pasteur, Université Paris Cité, Malaria Parasite Biology and Vaccines Unit, F-75015 Paris, France; Paris Cité Université, École Doctorale ED562 ‘BioSPC’, F-75006 Paris, FranceInstitut Pasteur, Université Paris Cité, Hub de Bioinformatique et Biostatistique, Département Biologie Computationnelle, USR 3756 , F-75015, Paris, FranceInstitut Pasteur, Université Paris Cité, Biomics Platform, C2RT, F-75015 Paris, FranceUniversité de Strasbourg, Institute of Parasitology and Tropical Diseases, UR7292 Dynamics of Host-Pathogen Interactions, F-67000 Strasbourg, FranceInstitut Pasteur, Université Paris Cité, Malaria Parasite Biology and Vaccines Unit, F-75015 Paris, FranceInstitut Pasteur, Université Paris Cité, Malaria Genetics and Resistance Unit, INSERM U1201, F-75015 Paris, France; Université de Strasbourg, Institute of Parasitology and Tropical Diseases, UR7292 Dynamics of Host-Pathogen Interactions, F-67000 Strasbourg, FranceVivax malaria is an infectious disease caused by Plasmodium vivax, a parasitic protozoan transmitted by female Anopheline mosquitoes. Historically, vivax malaria has often been regarded as a benign self-limiting infection due to the observation of low parasitemia in Duffy-positive patients in endemic transmission areas and the virtual absence of infections in Duffy-negative individuals in Sub Saharan Africa. However, the latest estimates show that the burden of the disease is not decreasing in many countries and cases of vivax infections in Duffy-negative individuals are increasingly reported throughout Africa. This raised questions about the accuracy of diagnostics and the evolution of interactions between humans and parasites. For a long time, our knowledge on P. vivax biology has been hampered due to the limited access to biological material and the lack of robust in vitro culture methods. Consequently, little is currently known about P. vivax blood stage invasion mechanisms. The introduction of omics technologies with novel and accessible techniques such as third generation sequencing and RNA sequencing at single cell level, two-dimensional electrophoresis, liquid chromatography, and mass spectrometry, has progressively improved our understanding of P. vivax genetics, transcripts, and proteins. This review aims to provide broad insights into P. vivax invasion mechanisms generated by genomics, transcriptomics, and proteomics and to illustrate the importance of integrated multi-omics studies.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.95/Malaria<i>P. vivax</i>InvasionDuffy negativityOmics |
| spellingShingle | Bouyssou, Isabelle Martínez, Francisco José Campagne, Pascal Ma, Laurence Doderer-Lang, Cécile Chitnis, Chetan E. Ménard, Didier Plasmodium vivax blood stage invasion pathways: Contribution of omics technologies in deciphering molecular and cellular mechanisms Comptes Rendus Biologies Malaria <i>P. vivax</i> Invasion Duffy negativity Omics |
| title | Plasmodium vivax blood stage invasion pathways: Contribution of omics technologies in deciphering molecular and cellular mechanisms |
| title_full | Plasmodium vivax blood stage invasion pathways: Contribution of omics technologies in deciphering molecular and cellular mechanisms |
| title_fullStr | Plasmodium vivax blood stage invasion pathways: Contribution of omics technologies in deciphering molecular and cellular mechanisms |
| title_full_unstemmed | Plasmodium vivax blood stage invasion pathways: Contribution of omics technologies in deciphering molecular and cellular mechanisms |
| title_short | Plasmodium vivax blood stage invasion pathways: Contribution of omics technologies in deciphering molecular and cellular mechanisms |
| title_sort | plasmodium vivax blood stage invasion pathways contribution of omics technologies in deciphering molecular and cellular mechanisms |
| topic | Malaria <i>P. vivax</i> Invasion Duffy negativity Omics |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.95/ |
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