High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction
Abstract Background The impact of insulin resistance on the prognosis of heart failure with preserved ejection fraction (HFpEF) remains unknown. This study aimed to investigate the association between the triglyceride-glucose (TyG) index, an easily calculated marker of insulin resistance, and the lo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-02001-4 |
| _version_ | 1797454013044621312 |
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| author | Qing Zhou Jie Yang Hongyi Tang Zexuan Guo Wenyue Dong Yiting Wang Xiangbin Meng Kuo Zhang Wenyao Wang Chunli Shao Xinwei Hua Yi-Da Tang |
| author_facet | Qing Zhou Jie Yang Hongyi Tang Zexuan Guo Wenyue Dong Yiting Wang Xiangbin Meng Kuo Zhang Wenyao Wang Chunli Shao Xinwei Hua Yi-Da Tang |
| author_sort | Qing Zhou |
| collection | DOAJ |
| description | Abstract Background The impact of insulin resistance on the prognosis of heart failure with preserved ejection fraction (HFpEF) remains unknown. This study aimed to investigate the association between the triglyceride-glucose (TyG) index, an easily calculated marker of insulin resistance, and the long-term prognosis of HFpEF. Methods A total of 823 patients with HFpEF were enrolled in the study. The TyG index was determined using the formula ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). The primary endpoint was all-cause death. The secondary endpoints were cardiovascular (CV) death and heart failure (HF) rehospitalization. Restricted cubic spline, multivariate Cox proportional hazard models, and competing risk models were used for analyses. Results During a median follow-up period of 3.16 years, 147 (17.8%) all-cause deaths, 139 (16.8%) CV deaths, and 222 (27.0%) HF rehospitalizations occurred. Restricted cubic spline analysis revealed a J-shaped association between the TyG index and the mortality and rehospitalization rates. In the multivariate Cox proportional hazard models, compared with those in the lowest TyG index tertile, patients in the highest tertile exhibited the greatest susceptibility to all-cause death (HR 1.53, 95% CI 1.19–1.98) and CV death (HR 1.52, 95% CI 1.19–1.96). In the competing risk model, a significant association between the TyG index and HF rehospitalization was observed (HR 1.31, 95% CI, 1.07–1.61). Conclusion A high TyG index is associated with an increased risk of mortality and rehospitalization in patients with HFpEF. The TyG index may serve as a promising prognostic marker for patients with HFpEF. |
| first_indexed | 2024-03-09T15:31:07Z |
| format | Article |
| id | doaj.art-526d4f3f07da4aa99cde3f0038ea4523 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-09T15:31:07Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-526d4f3f07da4aa99cde3f0038ea45232023-11-26T12:15:49ZengBMCCardiovascular Diabetology1475-28402023-09-0122111210.1186/s12933-023-02001-4High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fractionQing Zhou0Jie Yang1Hongyi Tang2Zexuan Guo3Wenyue Dong4Yiting Wang5Xiangbin Meng6Kuo Zhang7Wenyao Wang8Chunli Shao9Xinwei Hua10Yi-Da Tang11Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Graduate School of Peking Union Medical College, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Institute of Vascular Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Peking University, Peking UniversityDepartment of Cardiology, Institute of Vascular Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Peking University, Peking UniversityDepartment of Cardiology, Institute of Vascular Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Peking University, Peking UniversitySchool of Basic Medical Sciences, Peking UniversitySchool of Basic Medical Sciences, Peking UniversityDepartment of Cardiology, Institute of Vascular Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Peking University, Peking UniversityDepartment of Cardiology, State Key Laboratory of Cardiovascular Disease, Graduate School of Peking Union Medical College, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Institute of Vascular Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Peking University, Peking UniversityDepartment of Cardiology, Institute of Vascular Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Peking University, Peking UniversityDepartment of Cardiology, Institute of Vascular Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Peking University, Peking UniversityDepartment of Cardiology, Institute of Vascular Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Peking University, Peking UniversityAbstract Background The impact of insulin resistance on the prognosis of heart failure with preserved ejection fraction (HFpEF) remains unknown. This study aimed to investigate the association between the triglyceride-glucose (TyG) index, an easily calculated marker of insulin resistance, and the long-term prognosis of HFpEF. Methods A total of 823 patients with HFpEF were enrolled in the study. The TyG index was determined using the formula ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). The primary endpoint was all-cause death. The secondary endpoints were cardiovascular (CV) death and heart failure (HF) rehospitalization. Restricted cubic spline, multivariate Cox proportional hazard models, and competing risk models were used for analyses. Results During a median follow-up period of 3.16 years, 147 (17.8%) all-cause deaths, 139 (16.8%) CV deaths, and 222 (27.0%) HF rehospitalizations occurred. Restricted cubic spline analysis revealed a J-shaped association between the TyG index and the mortality and rehospitalization rates. In the multivariate Cox proportional hazard models, compared with those in the lowest TyG index tertile, patients in the highest tertile exhibited the greatest susceptibility to all-cause death (HR 1.53, 95% CI 1.19–1.98) and CV death (HR 1.52, 95% CI 1.19–1.96). In the competing risk model, a significant association between the TyG index and HF rehospitalization was observed (HR 1.31, 95% CI, 1.07–1.61). Conclusion A high TyG index is associated with an increased risk of mortality and rehospitalization in patients with HFpEF. The TyG index may serve as a promising prognostic marker for patients with HFpEF.https://doi.org/10.1186/s12933-023-02001-4Heart failure with preserved ejection fractionTriglyceride-glucose indexInsulin resistanceMortality |
| spellingShingle | Qing Zhou Jie Yang Hongyi Tang Zexuan Guo Wenyue Dong Yiting Wang Xiangbin Meng Kuo Zhang Wenyao Wang Chunli Shao Xinwei Hua Yi-Da Tang High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction Cardiovascular Diabetology Heart failure with preserved ejection fraction Triglyceride-glucose index Insulin resistance Mortality |
| title | High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction |
| title_full | High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction |
| title_fullStr | High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction |
| title_full_unstemmed | High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction |
| title_short | High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction |
| title_sort | high triglyceride glucose tyg index is associated with poor prognosis of heart failure with preserved ejection fraction |
| topic | Heart failure with preserved ejection fraction Triglyceride-glucose index Insulin resistance Mortality |
| url | https://doi.org/10.1186/s12933-023-02001-4 |
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