Metabolic Syndrome features and risk of neural tube defects
<p>Abstract</p> <p>Background</p> <p>Maternal obesity and pre-pregnancy diabetes mellitus, features of the metabolic syndrome (MetSyn), are individual risk factors for neural tube defects (NTD). Whether they, in combination with additional features of MetSyn, alter this...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-09-01
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| Series: | BMC Pregnancy and Childbirth |
| Online Access: | http://www.biomedcentral.com/1471-2393/7/21 |
| _version_ | 1811283002408304640 |
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| author | Wong Pui-Yuen Wyatt Philip R Meier Chris Vermeulen Marian J Thompson Miles D Ray Joel G Summers Anne M Farrell Sandra A Cole David EC |
| author_facet | Wong Pui-Yuen Wyatt Philip R Meier Chris Vermeulen Marian J Thompson Miles D Ray Joel G Summers Anne M Farrell Sandra A Cole David EC |
| author_sort | Wong Pui-Yuen |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Maternal obesity and pre-pregnancy diabetes mellitus, features of the metabolic syndrome (MetSyn), are individual risk factors for neural tube defects (NTD). Whether they, in combination with additional features of MetSyn, alter this risk is not known. We evaluated the risk of NTD in association with maternal features of the MetSyn.</p> <p>Methods</p> <p>We used a population-based case-control study design in the province of Ontario, Canada. Cases and controls were derived from women who underwent antenatal maternal screening (MSS) at 15 to 20 weeks' gestation. There were 89 maternal cases with, and 434 controls without, an NTD-affected singleton pregnancy. Maternal features of MetSyn were defined by the presence of pre-pregnancy diabetes mellitus, body weight ≥ 90th centile among controls, non-white ethnicity and/or serum highly sensitive C-reactive protein (hsCRP) ≥ 75th centile of controls. Since hsCRP naturally increases in pregnancy, analyses were performed with, and without, the inclusion of hsCRP in the model.</p> <p>Results</p> <p>Mean hsCRP concentrations were exceptionally high among study cases and controls (6.1 and 6.4 mg/L, respectively). When hsCRP was excluded from the model, the adjusted odds ratios for NTD were 1.9 (95% confidence interval 1.1–3.4) in the presence 1 feature of MetSyn, and 6.1 (1.1–32.9) in the presence of 2 or more features. When hsCRP was included, the respective risk estimates were attenuated to 1.6 (0.88–2.8) and 3.1 (1.2–8.3).</p> <p>Conclusion</p> <p>We found about 2-fold and 6-fold higher risk for NTD in the presence 1, and 2 or more features, of the metabolic syndrome, respectively. It is not clear whether this risk is altered by the presence of a high serum hsCRP concentration.</p> |
| first_indexed | 2024-04-13T02:02:40Z |
| format | Article |
| id | doaj.art-526f90fe9e2b4d0aa4fd95ff09814cd0 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-13T02:02:40Z |
| publishDate | 2007-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-526f90fe9e2b4d0aa4fd95ff09814cd02022-12-22T03:07:34ZengBMCBMC Pregnancy and Childbirth1471-23932007-09-01712110.1186/1471-2393-7-21Metabolic Syndrome features and risk of neural tube defectsWong Pui-YuenWyatt Philip RMeier ChrisVermeulen Marian JThompson Miles DRay Joel GSummers Anne MFarrell Sandra ACole David EC<p>Abstract</p> <p>Background</p> <p>Maternal obesity and pre-pregnancy diabetes mellitus, features of the metabolic syndrome (MetSyn), are individual risk factors for neural tube defects (NTD). Whether they, in combination with additional features of MetSyn, alter this risk is not known. We evaluated the risk of NTD in association with maternal features of the MetSyn.</p> <p>Methods</p> <p>We used a population-based case-control study design in the province of Ontario, Canada. Cases and controls were derived from women who underwent antenatal maternal screening (MSS) at 15 to 20 weeks' gestation. There were 89 maternal cases with, and 434 controls without, an NTD-affected singleton pregnancy. Maternal features of MetSyn were defined by the presence of pre-pregnancy diabetes mellitus, body weight ≥ 90th centile among controls, non-white ethnicity and/or serum highly sensitive C-reactive protein (hsCRP) ≥ 75th centile of controls. Since hsCRP naturally increases in pregnancy, analyses were performed with, and without, the inclusion of hsCRP in the model.</p> <p>Results</p> <p>Mean hsCRP concentrations were exceptionally high among study cases and controls (6.1 and 6.4 mg/L, respectively). When hsCRP was excluded from the model, the adjusted odds ratios for NTD were 1.9 (95% confidence interval 1.1–3.4) in the presence 1 feature of MetSyn, and 6.1 (1.1–32.9) in the presence of 2 or more features. When hsCRP was included, the respective risk estimates were attenuated to 1.6 (0.88–2.8) and 3.1 (1.2–8.3).</p> <p>Conclusion</p> <p>We found about 2-fold and 6-fold higher risk for NTD in the presence 1, and 2 or more features, of the metabolic syndrome, respectively. It is not clear whether this risk is altered by the presence of a high serum hsCRP concentration.</p>http://www.biomedcentral.com/1471-2393/7/21 |
| spellingShingle | Wong Pui-Yuen Wyatt Philip R Meier Chris Vermeulen Marian J Thompson Miles D Ray Joel G Summers Anne M Farrell Sandra A Cole David EC Metabolic Syndrome features and risk of neural tube defects BMC Pregnancy and Childbirth |
| title | Metabolic Syndrome features and risk of neural tube defects |
| title_full | Metabolic Syndrome features and risk of neural tube defects |
| title_fullStr | Metabolic Syndrome features and risk of neural tube defects |
| title_full_unstemmed | Metabolic Syndrome features and risk of neural tube defects |
| title_short | Metabolic Syndrome features and risk of neural tube defects |
| title_sort | metabolic syndrome features and risk of neural tube defects |
| url | http://www.biomedcentral.com/1471-2393/7/21 |
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